Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch
Journal Article
·
· Chemistry and Biology
The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 {angstrom} crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE SC OFFICE OF SCIENCE (SC)
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 1041815
- Report Number(s):
- BNL-97493-2012-JA; TRN: US201212%%227
- Journal Information:
- Chemistry and Biology, Vol. 18, Issue 3; ISSN 1074-5521
- Country of Publication:
- United States
- Language:
- English
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