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Title: Pyridostigmine used as a nerve agent pretreatment under wartime conditions. (Reannouncement with new availability information)

Abstract

During Operation Desert Storm there was a credible threat of chemical warfare even though there was never actual use of chemical agents. Intelligence reports indicated that the Iraqi chemical arsenal contained nerve, vesicant, and blood agents. Nerve agents are organophosphorus inhibitors of acetylcholinesterase, such as sarin and tabun. The vesicants are skin blistering compounds, such as mustards and arsenicals, while blood agents are the cyanides, inhibitors of cytochrome oxidase. The US Armed Force`s approach to the medical management of actual or anticipated nerve agent injuries employs a regimen that consists of pretreatment with pyridostigmine bromide tablets prior to nerve agent exposure followed by atropine citrate and pralidoxime chloride by autoinjector intramuscularly on actual exposure. Proper administration of this drug combination provides significantly increased survival after lethal exposures to nerve agents above that provided by atropine and pralidoxime therapy alone. The recent addition of pyridostigmine to the US therapeutic regimen for nerve agent poisoning was based on efficacy data in animals and safety studies in humans.

Authors:
; ;
Publication Date:
Research Org.:
Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
OSTI Identifier:
104162
Report Number(s):
AD-A-243071/8/XAB; USAMRICD-P-91-012
TRN: 52420283
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 7 Aug 1991
Country of Publication:
United States
Language:
English
Subject:
45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; CHEMICAL WARFARE AGENTS; TOXICITY; PREVENTIVE MEDICINE

Citation Formats

Keeler, J R, Hurst, C G, and Dunn, M A. Pyridostigmine used as a nerve agent pretreatment under wartime conditions. (Reannouncement with new availability information). United States: N. p., 1991. Web.
Keeler, J R, Hurst, C G, & Dunn, M A. Pyridostigmine used as a nerve agent pretreatment under wartime conditions. (Reannouncement with new availability information). United States.
Keeler, J R, Hurst, C G, and Dunn, M A. 1991. "Pyridostigmine used as a nerve agent pretreatment under wartime conditions. (Reannouncement with new availability information)". United States.
@article{osti_104162,
title = {Pyridostigmine used as a nerve agent pretreatment under wartime conditions. (Reannouncement with new availability information)},
author = {Keeler, J R and Hurst, C G and Dunn, M A},
abstractNote = {During Operation Desert Storm there was a credible threat of chemical warfare even though there was never actual use of chemical agents. Intelligence reports indicated that the Iraqi chemical arsenal contained nerve, vesicant, and blood agents. Nerve agents are organophosphorus inhibitors of acetylcholinesterase, such as sarin and tabun. The vesicants are skin blistering compounds, such as mustards and arsenicals, while blood agents are the cyanides, inhibitors of cytochrome oxidase. The US Armed Force`s approach to the medical management of actual or anticipated nerve agent injuries employs a regimen that consists of pretreatment with pyridostigmine bromide tablets prior to nerve agent exposure followed by atropine citrate and pralidoxime chloride by autoinjector intramuscularly on actual exposure. Proper administration of this drug combination provides significantly increased survival after lethal exposures to nerve agents above that provided by atropine and pralidoxime therapy alone. The recent addition of pyridostigmine to the US therapeutic regimen for nerve agent poisoning was based on efficacy data in animals and safety studies in humans.},
doi = {},
url = {https://www.osti.gov/biblio/104162}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Aug 07 00:00:00 EDT 1991},
month = {Wed Aug 07 00:00:00 EDT 1991}
}

Technical Report:
Other availability
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