Dihydro-resveratrol-A potent dietary polyphenol
Journal Article
·
· Bioorganic and Medicinal Chemistry Letters
- ORNL
- N.N. Blokhin Russian Cancer Research Center
- Hefei National Laboratory for the Physical Sciences at Microscale
- Chemical Diversity Research Institute
Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and -562).
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- DE-AC05-00OR22725
- OSTI ID:
- 1038463
- Journal Information:
- Bioorganic and Medicinal Chemistry Letters, Vol. 20, Issue 20; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- English
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