Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution
- NCI
There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 {angstrom} resolution are presented.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- NIHNCI
- OSTI ID:
- 1036327
- Journal Information:
- Acta Crystallographica Section D: Biological Crystallography, Vol. 67, Issue 5; ISSN 0907-4449
- Country of Publication:
- United States
- Language:
- ENGLISH
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