Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors
Journal Article
·
· Bioorg. Med. Chem. Lett.
- J
A series of indazoles have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallography and solution activity resulted in lead-like compounds with good pharmaceutical properties.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- INDUSTRY
- OSTI ID:
- 1025629
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 21, Issue (16) ; 08, 2011
- Country of Publication:
- United States
- Language:
- ENGLISH
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