Unraveling pancreatic islet biology by quantitative proteomics
The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1025087
- Report Number(s):
- PNNL-SA-77799; 36197; 400412000; TRN: US201120%%271
- Journal Information:
- Expert Review of Proteomics, 8(4):495-504, Vol. 8, Issue 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
60 APPLIED LIFE SCIENCES
BIOLOGY
BLOOD
GLUCOSE
HOMEOSTASIS
INSULIN
METABOLIC DISEASES
PATHOGENESIS
PEPTIDE HORMONES
SECRETION
pancreatic islets
pancreatic beta-cells
quantitative proteomics
diabetes
signaling pathway
insulin resistance
2-dimensional gel-electrophoresis
spectrometry-based proteomics
beta-cell apoptosis
chromatography-mass spectrometry
differential protein expression
in-vivo
insulin-secretion
elevated glucose
oxidative stress
accurate mass
Environmental Molecular Sciences Laboratory