Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor
Journal Article
·
· Angew. Chem. Int. Ed.
- UC
The 204-residue covalent-dimer vascular endothelial growth factor (VEGF, see picture) with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- DOE - BASIC ENERGY SCIENCESNIH
- OSTI ID:
- 1025048
- Journal Information:
- Angew. Chem. Int. Ed., Vol. 50, Issue (35) ; 08, 2011; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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