Stereochemistry Determination by Powder X-ray Diffraction Analysis and NMR Spectroscopy Residual Dipolar Couplings

Journal Article · Thu Jan 01 00:00:00 EST 2009 · Angewandte Chemie International Edition

DOI:https://doi.org/10.1002/anie.200900760· OSTI ID:1019704

Garcia, M; Pagola, S; Navarro-Vasquez, A; Phillips, D; Gayathri, C; Krakauer, H; Stephens, P; Nicotra, V; Gil, R

A matter of technique: For a new steroidal lactol, jaborosalactol 24 (1), isolated from Jaborosa parviflora, NMR spectroscopy residual dipolar couplings and powder X-ray diffraction analysis independently gave the same stereochemistry at C23-C26. Conventional NMR spectroscopic techniques, such as NOE and {sup 3}J coupling-constant analysis failed to unambiguously determine this stereochemistry.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
• Sponsoring Organization: DOE - OFFICE OF SCIENCE
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1019704
• Report Number(s): BNL-95550-2011-JA; TRN: US201115%%344
• Journal Information: Angewandte Chemie International Edition, Vol. 48, Issue 31; ISSN 1433-7851
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
SPECTROSCOPY
STEREOCHEMISTRY
X-RAY DIFFRACTION
national synchrotron light source