Hard x-ray Zernike Microscopy Reaches 30 nm Resolution
Abstract
Since its invention in 1930, Zernike phase contrast has been a pillar in optical microscopy and more recently in x-ray microscopy, in particular for low-absorption-contrast biological specimens. We experimentally demonstrate that hard-x-ray Zernike microscopy now reaches a lateral resolution below 30 nm while strongly enhancing the contrast, thus opening many new research opportunities in biomedicine and materials science.
- Authors:
- Publication Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Org.:
- DOE - OFFICE OF SCIENCE
- OSTI Identifier:
- 1019511
- Report Number(s):
- BNL-95253-2011-JA
Journal ID: ISSN 0146-9592; KC020401G; TRN: US1103657
- DOE Contract Number:
- DE-AC02-98CH10886
- Resource Type:
- Journal Article
- Journal Name:
- Optics Letters
- Additional Journal Information:
- Journal Volume: 36; Journal Issue: 7; Journal ID: ISSN 0146-9592
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 43 PARTICLE ACCELERATORS; INVENTIONS; MICROSCOPY; OPENINGS; OPTICAL MICROSCOPY; RESOLUTION; Zernike Microscopy; Hard X-ray
Citation Formats
Chen, Y T, Chu, Y, Chen, T-Y, Yi, J, Lee, W-K, Wang, C-L, Kempson, I M, Hwu, Y, Gajdosik, V, and Margaritondo, G. Hard x-ray Zernike Microscopy Reaches 30 nm Resolution. United States: N. p., 2011.
Web. doi:10.1364/OL.36.001269.
Chen, Y T, Chu, Y, Chen, T-Y, Yi, J, Lee, W-K, Wang, C-L, Kempson, I M, Hwu, Y, Gajdosik, V, & Margaritondo, G. Hard x-ray Zernike Microscopy Reaches 30 nm Resolution. United States. https://doi.org/10.1364/OL.36.001269
Chen, Y T, Chu, Y, Chen, T-Y, Yi, J, Lee, W-K, Wang, C-L, Kempson, I M, Hwu, Y, Gajdosik, V, and Margaritondo, G. 2011.
"Hard x-ray Zernike Microscopy Reaches 30 nm Resolution". United States. https://doi.org/10.1364/OL.36.001269.
@article{osti_1019511,
title = {Hard x-ray Zernike Microscopy Reaches 30 nm Resolution},
author = {Chen, Y T and Chu, Y and Chen, T-Y and Yi, J and Lee, W-K and Wang, C-L and Kempson, I M and Hwu, Y and Gajdosik, V and Margaritondo, G},
abstractNote = {Since its invention in 1930, Zernike phase contrast has been a pillar in optical microscopy and more recently in x-ray microscopy, in particular for low-absorption-contrast biological specimens. We experimentally demonstrate that hard-x-ray Zernike microscopy now reaches a lateral resolution below 30 nm while strongly enhancing the contrast, thus opening many new research opportunities in biomedicine and materials science.},
doi = {10.1364/OL.36.001269},
url = {https://www.osti.gov/biblio/1019511},
journal = {Optics Letters},
issn = {0146-9592},
number = 7,
volume = 36,
place = {United States},
year = {Wed Mar 30 00:00:00 EDT 2011},
month = {Wed Mar 30 00:00:00 EDT 2011}
}
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