Extreme Modulation Properties of Aromatic Fluorine
Journal Article
·
· Journal of Fluorine Chemistry
OSTI ID:1018594
- ORNL
Thorough examination of the current literature as well as publicly available databases allowed us to qualify aromatic fluorine as a unique modulator of biological properties of organic compounds. In some rare cases, introduction of fluorine increased biological activity 100,000 times and even higher. We have also identified several examples where aromatic fluorine substantially reduced biological activity. Selected individual cases of extreme modulation are presented and discussed in the paper.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE National Nuclear Security Administration (NNSA)
- DOE Contract Number:
- DE-AC05-00OR22725
- OSTI ID:
- 1018594
- Journal Information:
- Journal of Fluorine Chemistry, Vol. 132, Issue 2; ISSN 0022-1139
- Country of Publication:
- United States
- Language:
- English
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