Energy and Technology Review, April--May 1992

Technical Report · Sat Aug 01 00:00:00 EDT 1992

OSTI ID:10167841

Sefcik, J A ^[1]

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1. ed.

This issue of ``Energy and Technology Review`` address Biomedical Science at Lawrence Livermore National Laboratory. The broad mission of biomedical research at the Laboratory is to identify and characterize effects on human health arising from energy use and development. Our goal is to understand the molecular and cellular mechanisms that lead to adverse health effects and to develop technologies and resources to prevent or ameliorate them. We provide the scientific foundation for understanding the longterm health consequences of energy alternatives and for developing technological solutions for these issues. The multidisciplinary team researchers the fields of biochemistry, molecular biology, cellular biology, and genetics with the computational, physical, and engineering resources available to us from the wider pool of people and facilities at LLNL. To fulfill our mission, we bring together research efforts in human risk assessment, human genome organization, structural biology, and technology development. In the area of human risk assessment, we are developing methods to assess genetic alterations and ill-health effects directly in humans. Two articles in this issue of Energy and Technology Review describe some of our work on human risk assessment. The first article explains one of the new methods we developed to measure mutations in humans, namely, the glycophorin-A (GPA) assay. The second deals with moles and melanoma incidence among employees of LLNL. Our research interests have historically emphasized an understanding of the structure of mammalian chromosomes and chromatin, which package the DNA. This focus has been manifest in our studies of DNA and proteins in sperm, in the organization and isolation of DNA repair genes, and in developing an organizational map of the human genome with a specific focus on chromosome 19. The third article in this issue provides a succinct overview of the goals, science, and results coming from the Human Genome Project.

• Research Organization: Lawrence Livermore National Lab., CA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 10167841
• Report Number(s): UCRL-52000-92-4-5; ON: DE92018780
• Resource Relation: Other Information: PBD: 1992
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN POPULATIONS
BIOASSAY
CARCINOGENS
GENETIC EFFECTS
LAWRENCE LIVERMORE LABORATORY
RESEARCH PROGRAMS
MUTAGEN SCREENING
MUTAGENESIS
SOMATIC MUTATIONS
CYTOLOGICAL TECHNIQUES
CHEMOTHERAPY
TECHNOLOGY TRANSFER
MELANOMAS
SKIN DISEASES
SKIN
MELANIN
ANIMAL CELLS
COMPILED DATA
GENOME MUTATIONS
CHROMOSOMES
DNA
GENETIC MAPPING
BIOCHEMISTRY
550400
550200
GENETICS