Life Sciences Division and Center for Human Genome Studies. Annual report, 1991

Technical Report · Fri May 01 00:00:00 EDT 1992

OSTI ID:10154348

Spitzmiller, D; Bradbury, M; Cram, S ^[1]

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1. comps.

This report summarizes the research and development activities of Los Alamos National Laboratories Life Sciences Division and biological aspects of the Center for Human Genome Studies for the calendar year 1991. Selected research highlights include: yeast artificial chromosome libraries from flow sorted human chromosomes 16 and 21; distances between the antigen binding sites of three murine antibody subclasses measured using neutron and x-ray scattering; NFCR 10th anniversary highlights; kinase-mediated differences found in the cell cycle regulation of normal and transformed cells; and detecting mutations that cause Gaucher`s disease by denaturing gradient gel electrophoresis. Project descriptions include: genomic structure and regulation, molecular structure, cytometry, cell growth and differentiation, radiation biology and carcinogenesis, and pulmonary biology.

• Research Organization: Los Alamos National Lab., NM (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States); Department of Defense, Washington, DC (United States); National Aeronautics and Space Administration, Washington, DC (United States); Department of Agriculture, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 10154348
• Report Number(s): LA-12273-PR; ON: DE92016277
• Resource Relation: Other Information: PBD: May 1992
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GENETICS
RESEARCH PROGRAMS
PROGRESS REPORT
LANL
TOXICITY
BIOLOGY
CHROMOSOMES
DNA REPAIR
CARCINOGENESIS
RADIOBIOLOGY
MOLECULAR STRUCTURE
CLONING
PLANTS
GENETIC MAPPING
MUTATIONS
CHROMOSOME SORTING
DNA SEQUENCING
550400
550200
560300
550300
BIOCHEMISTRY
CHEMICALS METABOLISM AND TOXICOLOGY
CYTOLOGY