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Title: Ion funnel ion trap and process

Patent ·
OSTI ID:1015253
 [1];  [1];  [2];  [3];  [1]
  1. Richland, WA
  2. West Richland, WA
  3. Hermiston, OR
+ Show Author Affiliations

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RLO1830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,888,635
Application Number:
US Patent Application 12/156,360
OSTI ID:
1015253
Country of Publication:
United States
Language:
English

References (7)

Design of a new electrospray ion mobility mass spectrometer journal November 2001
A Tandem Ion Trap/Ion Mobility Spectrometer journal July 2000
Analysis of a drift tube at ambient pressure: Models and precise measurements in ion mobility spectrometry journal September 2001
Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry journal October 2007
A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry journal October 1997
High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces journal May 2005
An Ion Trap Interface for ESIāˆ’Ion Mobility Experiments journal October 1997

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