Modular strategies for PET imaging agents

Journal Article · Mon Mar 01 00:00:00 EST 2010 · Current Opinions in Chemical Biology

DOI:https://doi.org/10.1016/j.cbpa.2009.10.005· OSTI ID:1014287

Hooker, J M

In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and synthetic methodologies, in combination with advances in macromolecular delivery systems and gene-expression imaging, reflect a need to reduce radiosynthesis burden in order to accelerate imaging agent development. These new approaches, which are often mindful of existing infrastructure and available resources, are anticipated to provide a more approachable entry point for researchers interested in using PET to translate in vitro research to in vivo imaging.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: DOE - OFFICE OF SCIENCE
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1014287
• Report Number(s): BNL-91368-2010-JA; R&D Project: MO085; KP1602010; TRN: US1102715
• Journal Information: Current Opinions in Chemical Biology, Vol. 14, Issue 1; ISSN 1367-5931
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
IMPLEMENTATION
IN VITRO
IN VIVO
POSITRON COMPUTED TOMOGRAPHY
SYNTHESIS
TOMOGRAPHY
PET
imaging agents
in vitro imaging
in vivo imaging