Glutamate receptors at atomic resolution
- NIH
At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels seems to have been assembled from a kit consisting of discrete ligand-binding, ion-channel, modulatory and cytoplasmic domains. Crystallographic studies that exploit this unique architecture have greatly aided structural analysis of the ligand-binding core, but the results also pose a formidable challenge, namely that of resolving the allosteric mechanisms by which individual domains communicate and function in an intact receptor.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1007698
- Journal Information:
- Nature, Vol. 440, Issue 03, 2006
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
Journal Article
·
Mon Apr 27 00:00:00 EDT 2015
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:1007698
+1 more
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Journal Article
·
Fri Apr 26 00:00:00 EDT 2019
· Science
·
OSTI ID:1007698
+2 more
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
Journal Article
·
Mon Oct 27 00:00:00 EDT 2008
· EMBO J.
·
OSTI ID:1007698
+2 more