Seleninate in Place of Phosphate: Irreversible Inhibition of Protein Tyrosine Phosphatases
- Rutgers
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1006982
- Journal Information:
- J. Am. Chem. Soc., Vol. 130, Issue (40) ; 09, 2008; ISSN 0002-7863
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Mechanisms underlying the inhibitory effects of arsenic compounds on protein tyrosine phosphatase (PTP)
Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family
Journal Article
·
Sat Sep 15 00:00:00 EDT 2012
· Toxicology and Applied Pharmacology
·
OSTI ID:1006982
+5 more
Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)
Journal Article
·
Fri Aug 13 00:00:00 EDT 2010
· J. Med. Chem.
·
OSTI ID:1006982
+10 more
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family
Journal Article
·
Sat Jul 01 00:00:00 EDT 1989
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:1006982
+3 more