High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
- Pfizer
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4{angstrom} resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1006505
- Journal Information:
- J. Biol. Chem., Vol. 283, Issue (3) ; 01, 2008; ISSN 0021-9258
- Country of Publication:
- United States
- Language:
- ENGLISH
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