Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
Copper trafficking proteins, including the chaperone Atox1 and the P{sub 1B}-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1006126
- Journal Information:
- J. Am. Chem. Soc., Vol. 131, Issue (40) ; 10, 2009; ISSN 0002-7863
- Country of Publication:
- United States
- Language:
- ENGLISH
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