Progress in Using Mouse Inbred Strains, Consomics, and Mutants to Identify Genes Related to Stress, Anxiety, and Alcohol Phenotypes

Journal Article · Sun Jan 01 00:00:00 EST 2006 · Alcoholism: Clinical and Experimental Research

DOI:https://doi.org/10.1111/j.1530-0277.2006.00125.x· OSTI ID:1003583

Goldowitz, Daniel ^[1]; Matthews, Douglas B. ^[2]; Hamre, Kristin M. ^[1]; Mittleman, Guy ^[2]; Chesler, Elissa J ^[3]; Becker, Howard C. ^[4]; Lopez, Marcelo F. ^[4]; Jones, Sara R. ^[5]; Mathews, Tiffany A ^[5]; Miles, Michael F. ^[6]; Kerns, Robnet ^[6]; Grant, Kathleen A. ^[7]

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1. University of Tennessee Health Science Center, Memphis
2. University of Memphis
3. ORNL
4. Medical College of South Carolina, Charleston
5. Wake Forest University, Winston-Salem, NC
6. Medical College of Virginia, Richmond
7. Oregon Health and Science University, Portland

ALCOHOL ABUSE AND alcoholism result from the complex interplay of genetic and environmental factors. Stress is a factor that is widely thought to contribute to excessive drinking and alcoholism. One consequence of stressful experiences is anxiety, and there is a rich literature on the interactions between alcohol and anxiety. Less is known about brain mechanisms at the molecular, cellular, and system levels that mediate stress effects that contribute to excessive drinking and alcoholism. In addition, it is not clear whether and/or how genetic factors that contribute to excessive drinking interact with neural stress mechanisms.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mouse Genetics Research Facility
• Sponsoring Organization: USDOE Laboratory Directed Research and Development (LDRD) Program
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 1003583
• Journal Information: Alcoholism: Clinical and Experimental Research, Vol. 30, Issue 6; ISSN 0145-6008
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ALCOHOLS
BRAIN
GENES
GENETICS
MUTANTS
STRAINS
Ethanol Phenotyes
Behavioral Genetics
Stress
Alcohol
Gene Networks
Schedule-Induced Polydipsia
Mesolimbic Dopamine