Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis
Abstract
Amyloid is a complex pathologic matrix comprised principally of para-crystalline protein fibrils and heparan sulfate proteoglycans. Systemic amyloidoses are rare (~3500 new cases per year in the US); thus, routine diagnosis is often challenging, and effective treatment options are limited, resulting in high morbidity and mortality rates. Glycosaminoglycans contribute inextricably to the formation of amyloid fibrils and foster the deposition of amyloid in tissues. Those present in amyloid deposits are biochemically and electrochemically distinct from glycosaminoglycans found in the plasma membrane and extracellular matrices of healthy tissues due to the presence of a high degree of heparin-like hypersulfation. We have exploited this unique property and evaluated heparin-reactive peptides, such as p5+14. Herein we show efficacious detection of murine systemic amyloid in vivo by using molecular imaging, and the specific targeting of the peptide to major forms of human amyloid in tissue sections. Furthermore, we have demonstrated that the peptide also binds synthetic amyloid fibrils that lack glycosaminoglycans implying that the dense anionic motif present on heparin is mimicked by the amyloid protein fibril itself. These biochemical and functional data support the translation of radiolabeled peptide p5+14 for the clinical imaging of amyloid in patients; thus, providing a novel technique formore »
- Authors:
-
- Univ. of Tennessee Graduate School of Medicine, Knoxville, TN (United States). Dept. of Medicine; Univ. of Tennessee Graduate School of Medicine, Knoxville, TN (United States). Dept. of and Radiology
- Univ. of Tennessee Graduate School of Medicine, Knoxville, TN (United States). Dept. of Medicine
- Univ. of Tennessee Graduate School of Medicine, Knoxville, TN (United States). Dept. of and Radiology
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Bioscience Division; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computer Science and Mathematics Division
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1327576
- Grant/Contract Number:
- AC05-00OR22725; R01DK079984
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Molecules
- Additional Journal Information:
- Journal Volume: 20; Journal Issue: 5; Journal ID: ISSN 1420-3049
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; glycosaminoglycans; amyloidosis; peptide; imaging; modeling; SPECT; p5+14
Citation Formats
Wall, Jonathan, Martin, Emily B., Richey, Tina, Stuckey, Alan C., Macy, Sallie, Wooliver, Craig, Williams, Angela, Foster, James S., McWilliams-Koeppen, Penney, Uberbacher, Ed, Cheng, Xiaolin, and Kennel, Stephen J. Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis. United States: N. p., 2015.
Web. doi:10.3390/molecules20057657.
Wall, Jonathan, Martin, Emily B., Richey, Tina, Stuckey, Alan C., Macy, Sallie, Wooliver, Craig, Williams, Angela, Foster, James S., McWilliams-Koeppen, Penney, Uberbacher, Ed, Cheng, Xiaolin, & Kennel, Stephen J. Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis. United States. https://doi.org/10.3390/molecules20057657
Wall, Jonathan, Martin, Emily B., Richey, Tina, Stuckey, Alan C., Macy, Sallie, Wooliver, Craig, Williams, Angela, Foster, James S., McWilliams-Koeppen, Penney, Uberbacher, Ed, Cheng, Xiaolin, and Kennel, Stephen J. Mon .
"Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis". United States. https://doi.org/10.3390/molecules20057657. https://www.osti.gov/servlets/purl/1327576.
@article{osti_1327576,
title = {Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis},
author = {Wall, Jonathan and Martin, Emily B. and Richey, Tina and Stuckey, Alan C. and Macy, Sallie and Wooliver, Craig and Williams, Angela and Foster, James S. and McWilliams-Koeppen, Penney and Uberbacher, Ed and Cheng, Xiaolin and Kennel, Stephen J.},
abstractNote = {Amyloid is a complex pathologic matrix comprised principally of para-crystalline protein fibrils and heparan sulfate proteoglycans. Systemic amyloidoses are rare (~3500 new cases per year in the US); thus, routine diagnosis is often challenging, and effective treatment options are limited, resulting in high morbidity and mortality rates. Glycosaminoglycans contribute inextricably to the formation of amyloid fibrils and foster the deposition of amyloid in tissues. Those present in amyloid deposits are biochemically and electrochemically distinct from glycosaminoglycans found in the plasma membrane and extracellular matrices of healthy tissues due to the presence of a high degree of heparin-like hypersulfation. We have exploited this unique property and evaluated heparin-reactive peptides, such as p5+14. Herein we show efficacious detection of murine systemic amyloid in vivo by using molecular imaging, and the specific targeting of the peptide to major forms of human amyloid in tissue sections. Furthermore, we have demonstrated that the peptide also binds synthetic amyloid fibrils that lack glycosaminoglycans implying that the dense anionic motif present on heparin is mimicked by the amyloid protein fibril itself. These biochemical and functional data support the translation of radiolabeled peptide p5+14 for the clinical imaging of amyloid in patients; thus, providing a novel technique for prognostication, patient stratification, and monitoring response to therapy.},
doi = {10.3390/molecules20057657},
journal = {Molecules},
number = 5,
volume = 20,
place = {United States},
year = {Mon Apr 27 00:00:00 EDT 2015},
month = {Mon Apr 27 00:00:00 EDT 2015}
}
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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue
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Impact of Resistance Mutations on Inhibitor Binding to HIV-1 Integrase
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Ultrastructural organization of hemodialysis-associated β2-microglobulin amyloid fibrils
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Conformational Abs recognizing a generic amyloid fibril epitope
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In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis
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- Proceedings of the National Academy of Sciences, Vol. 102, Issue 18
In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides
journal, August 2011
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- Proceedings of the National Academy of Sciences, Vol. 108, Issue 34
A structural model for Alzheimer's -amyloid fibrils based on experimental constraints from solid state NMR
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Amyloid-specific Heparan Sulfate from Human Liver and Spleen
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Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis.
journal, July 1975
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Recent Insights into the Pathogenesis of Type AA Amyloidosis
journal, January 2011
- van der Hilst, J. C. H.
- The Scientific World JOURNAL, Vol. 11
Glycosaminoglycans are functional ligands for receptor for advanced glycation end-products in tumors
journal, February 2013
- Mizumoto, Shuji; Sugahara, Kazuyuki
- FEBS Journal, Vol. 280, Issue 10
Aspects on human amyloid forms and their fibril polypeptides: Human amyloid forms and their fibril polypeptides
journal, November 2005
- Westermark, Per
- FEBS Journal, Vol. 272, Issue 23
Systemic Amyloidoses
journal, June 2013
- Blancas-Mejía, Luis M.; Ramirez-Alvarado, Marina
- Annual Review of Biochemistry, Vol. 82, Issue 1
Radioimmunodetection of amyloid deposits in patients with AL amyloidosis
journal, September 2010
- Wall, Jonathan S.; Kennel, Stephen J.; Stuckey, Alan C.
- Blood, Vol. 116, Issue 13
I-TASSER server for protein 3D structure prediction
journal, January 2008
- Zhang, Yang
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Functional Transformation of Gastric Parietal Cells and Intracellular Trafficking of Ion Channels/Transporters in the Apical Canalicular Membrane Associated with Acid Secretion
journal, January 2011
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