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Title: Novel neutron sources at the Radiological Research Accelerator Facility

Abstract

Since the 1960s, the Radiological Research Accelerator Facility (RARAF) has been providing researchers in biology, chemistry and physics with advanced irradiation techniques, using charged particles, photons and neutrons. We are currently developing a unique facility at RARAF, to simulate neutron spectra from an improvised nuclear device (IND), based on calculations of the neutron spectrum at 1.5 km from the epicenter of the Hiroshima atom bomb. This is significantly different from a standard fission spectrum, because the spectrum changes as the neutrons are transported through air, and is dominated by neutron energies between 0.05 and 8 MeV. This facility will be based on a mixed proton/deuteron beam impinging on a thick beryllium target. A second, novel facility under development is our new neutron microbeam. The neutron microbeam will, for the first time, provide a kinematically collimated neutron beam, 10-20 micron in diameter. This facility is based on a proton microbeam, impinging on a thin lithium target near the threshold of the Li-7(p,n)Be-7 reaction. Lastly, this novel neutron microbeam will enable studies of neutron damage to small targets, such as single cells, individual organs within small animals or microelectronic components.

Authors:
 [1];  [1];  [1]; ORCiD logo [2];  [1];  [1];  [1]
  1. Columbia Univ., New York, NY (United States)
  2. Ohio Univ., Athens, OH (United States)
Publication Date:
Research Org.:
Ohio Univ., Athens, OH (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
Contributing Org.:
Ohio University, Columbia University
OSTI Identifier:
1257198
Grant/Contract Number:  
FG02-88ER40387
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Instrumentation
Additional Journal Information:
Journal Volume: 7; Journal Issue: 03; Journal ID: ISSN 1748-0221
Publisher:
Institute of Physics (IOP)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; 73 NUCLEAR PHYSICS AND RADIATION PHYSICS; energy neutrons; cells; transformation; microbeam; rays

Citation Formats

Xu, Yanping, Garty, G., Marino, S. A., Massey, Thomas Neal, Johnson, G. W., Randers-Pehrson, Gerhard, and Brenner, D. J. Novel neutron sources at the Radiological Research Accelerator Facility. United States: N. p., 2012. Web. doi:10.1088/1748-0221/7/03/C03031.
Xu, Yanping, Garty, G., Marino, S. A., Massey, Thomas Neal, Johnson, G. W., Randers-Pehrson, Gerhard, & Brenner, D. J. Novel neutron sources at the Radiological Research Accelerator Facility. United States. https://doi.org/10.1088/1748-0221/7/03/C03031
Xu, Yanping, Garty, G., Marino, S. A., Massey, Thomas Neal, Johnson, G. W., Randers-Pehrson, Gerhard, and Brenner, D. J. Fri . "Novel neutron sources at the Radiological Research Accelerator Facility". United States. https://doi.org/10.1088/1748-0221/7/03/C03031. https://www.osti.gov/servlets/purl/1257198.
@article{osti_1257198,
title = {Novel neutron sources at the Radiological Research Accelerator Facility},
author = {Xu, Yanping and Garty, G. and Marino, S. A. and Massey, Thomas Neal and Johnson, G. W. and Randers-Pehrson, Gerhard and Brenner, D. J.},
abstractNote = {Since the 1960s, the Radiological Research Accelerator Facility (RARAF) has been providing researchers in biology, chemistry and physics with advanced irradiation techniques, using charged particles, photons and neutrons. We are currently developing a unique facility at RARAF, to simulate neutron spectra from an improvised nuclear device (IND), based on calculations of the neutron spectrum at 1.5 km from the epicenter of the Hiroshima atom bomb. This is significantly different from a standard fission spectrum, because the spectrum changes as the neutrons are transported through air, and is dominated by neutron energies between 0.05 and 8 MeV. This facility will be based on a mixed proton/deuteron beam impinging on a thick beryllium target. A second, novel facility under development is our new neutron microbeam. The neutron microbeam will, for the first time, provide a kinematically collimated neutron beam, 10-20 micron in diameter. This facility is based on a proton microbeam, impinging on a thin lithium target near the threshold of the Li-7(p,n)Be-7 reaction. Lastly, this novel neutron microbeam will enable studies of neutron damage to small targets, such as single cells, individual organs within small animals or microelectronic components.},
doi = {10.1088/1748-0221/7/03/C03031},
journal = {Journal of Instrumentation},
number = 03,
volume = 7,
place = {United States},
year = {Fri Mar 16 00:00:00 EDT 2012},
month = {Fri Mar 16 00:00:00 EDT 2012}
}

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Works referenced in this record:

An accelerator-based neutron microbeam system for studies of radiation effects
journal, December 2010

  • Xu, Y.; Randers-Pehrson, G.; Marino, S. A.
  • Radiation Protection Dosimetry, Vol. 145, Issue 4
  • DOI: 10.1093/rpd/ncq424

The Columbia University sub-micron charged particle beam
journal, October 2009

  • Randers-Pehrson, Gerhard; Johnson, Gary W.; Marino, Stephen A.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 609, Issue 2-3
  • DOI: 10.1016/j.nima.2009.08.041

Neoplastic transformation of mouse C3H10T12 cells following exposure to neutrons does not involve mutation of ras gene as analyzed by SSCP and cycle sequencing
journal, October 1996

  • Freyer, Greg A.; Palmer, David A.; Yu, Yong
  • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 357, Issue 1-2
  • DOI: 10.1016/0027-5107(96)00130-3

Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons
journal, January 2000

  • C. Miller, S. A. Marino, J. Napoli,, R.
  • International Journal of Radiation Biology, Vol. 76, Issue 3
  • DOI: 10.1080/095530000138664

The R.B.E. of Different Energy Neutrons as Measured by the Haematopoietic Spleen-colony Technique
journal, January 1976

  • Carsten, A. L.; Bond, V. P.; Thompson, K.
  • International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 29, Issue 1
  • DOI: 10.1080/09553007614551561

Quantitative Assessment of the Cataractogenic Potential of Very Low Doses of Neutrons
journal, March 1996

  • Worgul, Basil V.; Medvedovsky, Cecily; Huang, Youping
  • Radiation Research, Vol. 145, Issue 3
  • DOI: 10.2307/3578991

New measurement of the relative scintillation efficiency of xenon nuclear recoils below 10 keV
journal, April 2009


DS02 fluence spectra for neutrons and gamma rays at Hiroshima and Nagasaki with fluence-to-kerma coefficients and transmission factors for sample measurements
journal, July 2007

  • Egbert, Stephen D.; Kerr, George D.; Cullings, Harry M.
  • Radiation and Environmental Biophysics, Vol. 46, Issue 4
  • DOI: 10.1007/s00411-007-0120-5

Neutron RBEs for Cytopenia and Repopulation of Stroma and Hematopoietic Stem Cells: Mathematical Models of Marrow Cell Kinetics
journal, January 1997


Measurement of the 9 Be( p , n ) thick target spectrum for use in accelerator-based Boron Neutron Capture Therapy
journal, July 1996

  • Howard, W. B.; Yanch, J. C.; Grimes, S. M.
  • Medical Physics, Vol. 23, Issue 7
  • DOI: 10.1118/1.597684

Wall Roughness Effects on Stagnation-Point Heat Transfer Beneath an Impinging Liquid Jet
journal, February 1994

  • Gabour, L. A.; Lienhard, J. H.
  • Journal of Heat Transfer, Vol. 116, Issue 1
  • DOI: 10.1115/1.2910887

Single-Particle/Single-Cell Ion Microbeams as Probes of Biological Mechanisms
journal, August 2008

  • Bigelow, Alan W.; Brenner, David J.; Garty, Guy
  • IEEE Transactions on Plasma Science, Vol. 36, Issue 4
  • DOI: 10.1109/TPS.2008.927268

The Columbia University proton-induced soft X-ray microbeam
journal, September 2011

  • Harken, Andrew D.; Randers-Pehrson, Gerhard; Johnson, Gary W.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 269, Issue 18
  • DOI: 10.1016/j.nimb.2011.05.033

Thick target neutron yields for the 7Li(p,n)7Be reaction near threshold
journal, April 1999

  • Lee, C. L.; Zhou, X. -L.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 152, Issue 1
  • DOI: 10.1016/S0168-583X(99)00026-9

Theoretical study of short electrostatic lens for the Columbia ion microprobe
journal, April 2000

  • Dymnikov, Alexander D.; Brenner, David J.; Johnson, Gary
  • Review of Scientific Instruments, Vol. 71, Issue 4
  • DOI: 10.1063/1.1150512

The Columbia University microbeam II endstation for cell imaging and irradiation
journal, April 2005

  • Bigelow, A. W.; Ross, G. J.; Randers-Pehrson, G.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 231, Issue 1-4
  • DOI: 10.1016/j.nimb.2005.01.057

The Columbia University Single-Ion Microbeam
journal, August 2001


Works referencing / citing this record:

Predicting DNA damage foci and their experimental readout with 2D microscopy: a unified approach applied to photon and neutron exposures
journal, September 2019