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Title: Dried plum diet protects from bone loss caused by ionizing radiation

Abstract

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [3];  [4];  [1]
  1. NASA Ames Research Center, Moffett Field, CA (United States)
  2. Univ. of California, Irvine, CA (United States)
  3. Texas A & M Univ., College Station, TX (United States)
  4. Univ. of California, San Francisco, CA (United States)
Publication Date:
Research Org.:
NASA Ames Research Center (ARC), Moffett Field, Mountain View, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1242248
Grant/Contract Number:  
SC0001507
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 6; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; bone; targeted bone remodelling; osteoimmunology; radiotherapy

Citation Formats

Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., and Globus, R. K. Dried plum diet protects from bone loss caused by ionizing radiation. United States: N. p., 2016. Web. doi:10.1038/srep21343.
Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., & Globus, R. K. Dried plum diet protects from bone loss caused by ionizing radiation. United States. https://doi.org/10.1038/srep21343
Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., and Globus, R. K. Thu . "Dried plum diet protects from bone loss caused by ionizing radiation". United States. https://doi.org/10.1038/srep21343. https://www.osti.gov/servlets/purl/1242248.
@article{osti_1242248,
title = {Dried plum diet protects from bone loss caused by ionizing radiation},
author = {Schreurs, A. -S. and Shirazi-Fard, Y. and Shahnazari, M. and Alwood, J. S. and Truong, T. A. and Tahimic, C. G. T. and Limoli, C. L. and Turner, N. D. and Halloran, B. and Globus, R. K.},
abstractNote = {Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.},
doi = {10.1038/srep21343},
journal = {Scientific Reports},
number = ,
volume = 6,
place = {United States},
year = {Thu Feb 11 00:00:00 EST 2016},
month = {Thu Feb 11 00:00:00 EST 2016}
}

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Cited by: 40 works
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