Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. Four-ring OPAHs 1,9-benz-10-anthrone (BEZO) and benz(a)anthracene-7,12-dione (7,12-B[a]AQ) cause morphological aberrations and induce markers of oxidative stress in developing zebrafish with similar potency, but only 7,12-B[a]AQ induces robust Cyp1a protein expression. We investigated the role of the AHR in mediating the toxicity of BEZO and 7,12-B[a]AQ, and found that knockdown of AHR2 rescued developmental effects caused by both compounds. Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. Redox-homeostasis genes were affected similarly by these OPAHs, while 7,12-B[a]AQ preferentially activated phase 1 metabolism and BEZO uniquely decreased visual system genes. Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmentalmore »
- Authors:
-
- Oregon State Univ., Corvallis, OR (United States); Geisel School of Medicine at Dartmouth, Hanover, NH (United States)
- Oregon State Univ., Corvallis, OR (United States)
- Oregon State Univ., Corvallis, OR (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Publication Date:
- Research Org.:
- Oregon State Univ., Corvallis, OR (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1235029
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Toxicological Sciences
- Additional Journal Information:
- Journal Volume: 147; Journal Issue: 2; Journal ID: ISSN 1096-6080
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OPAH; zebrafish; aryl hydrocarbon receptor; RNA-seq; benzanthrone; benz(a)anthracene-7,12-dione
Citation Formats
Goodale, B. C., La Du, J., Tilton, S. C., Sullivan, C. M., Bisson, W. H., Waters, K. M., and Tanguay, R. L. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. United States: N. p., 2015.
Web. doi:10.1093/toxsci/kfv139.
Goodale, B. C., La Du, J., Tilton, S. C., Sullivan, C. M., Bisson, W. H., Waters, K. M., & Tanguay, R. L. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. United States. https://doi.org/10.1093/toxsci/kfv139
Goodale, B. C., La Du, J., Tilton, S. C., Sullivan, C. M., Bisson, W. H., Waters, K. M., and Tanguay, R. L. Fri .
"Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs". United States. https://doi.org/10.1093/toxsci/kfv139. https://www.osti.gov/servlets/purl/1235029.
@article{osti_1235029,
title = {Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs},
author = {Goodale, B. C. and La Du, J. and Tilton, S. C. and Sullivan, C. M. and Bisson, W. H. and Waters, K. M. and Tanguay, R. L.},
abstractNote = {Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. Four-ring OPAHs 1,9-benz-10-anthrone (BEZO) and benz(a)anthracene-7,12-dione (7,12-B[a]AQ) cause morphological aberrations and induce markers of oxidative stress in developing zebrafish with similar potency, but only 7,12-B[a]AQ induces robust Cyp1a protein expression. We investigated the role of the AHR in mediating the toxicity of BEZO and 7,12-B[a]AQ, and found that knockdown of AHR2 rescued developmental effects caused by both compounds. Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. Redox-homeostasis genes were affected similarly by these OPAHs, while 7,12-B[a]AQ preferentially activated phase 1 metabolism and BEZO uniquely decreased visual system genes. Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. Furthermore, identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds.},
doi = {10.1093/toxsci/kfv139},
journal = {Toxicological Sciences},
number = 2,
volume = 147,
place = {United States},
year = {Fri Jul 03 00:00:00 EDT 2015},
month = {Fri Jul 03 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 49 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Selective Aryl Hydrocarbon Receptor Modulator-Mediated Repression of CD55 Expression Induced by Cytokine Exposure
journal, May 2012
- Narayanan, Gitanjali A.; Murray, Iain A.; Krishnegowda, Gowdahalli
- Journal of Pharmacology and Experimental Therapeutics, Vol. 342, Issue 2
Ketone and quinone-substituted polycyclic aromatic hydrocarbons in mussel tissue, sediment, urban dust, and diesel particulate matrices
journal, September 2010
- Layshock, Julie A.; Wilson, Glenn; Anderson, Kim A.
- Environmental Toxicology and Chemistry, Vol. 29, Issue 11
Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis
journal, March 2014
- Soshilov, A. A.; Denison, M. S.
- Molecular and Cellular Biology, Vol. 34, Issue 9
Characterization of PM2.5-bound nitrated and oxygenated PAHs in two industrial sites of South China
journal, June 2012
- Wei, Shilong; Huang, Bo; Liu, Ming
- Atmospheric Research, Vol. 109-110
Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity
journal, January 1999
- Tian, Yanan; Ke, Sui; Denison, Michael. S.
- Journal of Biological Chemistry, Vol. 274, Issue 1
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.
journal, October 1992
- Imataka, H.; Sogawa, K.; Yasumoto, K.
- The EMBO Journal, Vol. 11, Issue 10
Integrated analyses of the transcriptome and small RNA of the hemiparasitic plant Monochasma savatieri before and after establishment of parasite-host association
journal, February 2021
- Chen, Lanlan; Guo, Qiaosheng; Zhu, Zaibiao
- BMC Plant Biology, Vol. 21, Issue 1
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
journal, November 2013
- Goodale, Britton C.; Tilton, Susan C.; Corvi, Margaret M.
- Toxicology and Applied Pharmacology, Vol. 272, Issue 3
TopHat: discovering splice junctions with RNA-Seq
journal, March 2009
- Trapnell, Cole; Pachter, Lior; Salzberg, Steven L.
- Bioinformatics, Vol. 25, Issue 9
Role of AHR2 in the Expression of Novel Cytochrome P450 1 Family Genes, Cell Cycle Genes, and Morphological Defects in Developing Zebra Fish Exposed to 3,3′,4,4′,5-Pentachlorobiphenyl or 2,3,7,8-Tetrachlorodibenzo-p-dioxin
journal, August 2007
- Jönsson, Maria E.; Jenny, Matthew J.; Woodin, Bruce R.
- Toxicological Sciences, Vol. 100, Issue 1
The variation of street air levels of PAH and other mutagenic PAC in relation to regulations of traffic emissions and the impact of atmospheric processes
journal, September 1999
- Nielsen, Torben; Feilberg, Anders; Binderup, Mona-Lise
- Environmental Science and Pollution Research, Vol. 6, Issue 3
The PAS Superfamily: Sensors of Environmental and Developmental Signals
journal, April 2000
- Gu, Yi-Zhong; Hogenesch, John B.; Bradfield, Christopher A.
- Annual Review of Pharmacology and Toxicology, Vol. 40, Issue 1
Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants
journal, July 2006
- Reimers, Mark J.; La Du, Jane K.; Periera, Cliff B.
- Neurotoxicology and Teratology, Vol. 28, Issue 4
Comparative effect of benzanthrone and 3-bromobenzanthrone on hepatic xenobiotic metabolism and anti-oxidative defense system in guinea pigs
journal, February 2003
- Singh, Ravindra P.; Khanna, Raj; Kaw, Jawahar L.
- Archives of Toxicology, Vol. 77, Issue 2
Arginase: an old enzyme with new tricks
journal, June 2015
- Caldwell, Ruth B.; Toque, Haroldo A.; Narayanan, S. Priya
- Trends in Pharmacological Sciences, Vol. 36, Issue 6
Functional and Genetic Diversity in the Concentrative Nucleoside Transporter, CNT1, in Human Populations
journal, February 2004
- Gray, Jennifer H.; Mangravite, Lara M.; Owen, Ryan P.
- Molecular Pharmacology, Vol. 65, Issue 3
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.
journal, June 2002
- Boström, Carl-Elis; Gerde, Per; Hanberg, Annika
- Environmental Health Perspectives, Vol. 110, Issue suppl 3
Role of biological antioxidants in benzanthrone toxicity
journal, June 2001
- Dwivedi, Neelam; Das, Mukul; Khanna, Subhash
- Archives of Toxicology, Vol. 75, Issue 4
Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists
journal, December 2014
- Brown, Daniel R.; Clark, Bryan W.; Garner, Lindsey V. T.
- Environmental Science and Pollution Research, Vol. 22, Issue 11
Risk Assessment Related to Atmospheric Polycyclic Aromatic Hydrocarbons in Gas and Particle Phases near Industrial Sites
journal, August 2011
- Ramírez, Noelia; Cuadras, Anna; Rovira, Enric
- Environmental Health Perspectives, Vol. 119, Issue 8
Knockdown of a Zebrafish Aryl Hydrocarbon Receptor Repressor (AHRRa) Affects Expression of Genes Related to Photoreceptor Development and Hematopoiesis
journal, March 2014
- Aluru, Neelakanteswar; Jenny, Matthew J.; Hahn, Mark E.
- Toxicological Sciences, Vol. 139, Issue 2
Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function
journal, September 2002
- Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro
- Biochemical Pharmacology, Vol. 64, Issue 5-6
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes
journal, January 2008
- Dvorak, Zdenek; Vrzal, Radim; Henklova, Pavla
- Biochemical Pharmacology, Vol. 75, Issue 2
Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air
journal, February 2002
- Boström, Carl-Elis; Gerde, Per; Hanberg, Annika
- Environmental Health Perspectives, Vol. 110, Issue s3
A new mathematical model for relative quantification in real-time RT-PCR
journal, May 2001
- Pfaffl, M. W.
- Nucleic Acids Research, Vol. 29, Issue 9
Attenuation of Benzanthrone Toxicity by Ascorbic Acid in Guinea Pigs
journal, January 1994
- Das, Mukul; Garg, Kalpana; Singh, Giriraj B.
- Toxicological Sciences, Vol. 22, Issue 3
Cyp1a reporter zebrafish reveals target tissues for dioxin
journal, June 2013
- Kim, Kun-Hee; Park, Hye-Jeong; Kim, Jin Hee
- Aquatic Toxicology, Vol. 134-135
Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish
journal, September 2014
- Gerlach, Cory V.; Das, Siba R.; Volz, David C.
- Aquatic Toxicology, Vol. 154
Bioinformatics resource manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools
journal, November 2012
- Tilton, Susan C.; Tal, Tamara L.; Scroggins, Sheena M.
- BMC Bioinformatics, Vol. 13, Issue 1
Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved
journal, October 2013
- Huang, Lixing; Wang, Chonggang; Zhang, Youyu
- Journal of Hazardous Materials, Vol. 261
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
journal, January 2020
- Parisi, Giulia; Saco, Justin D.; Salazar, Felix B.
- Nature Communications, Vol. 11, Issue 1
Gene ontology analysis for RNA-seq: accounting for selection bias
journal, January 2010
- Young, Matthew D.; Wakefield, Matthew J.; Smyth, Gordon K.
- Genome Biology, Vol. 11, Issue 2
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
journal, November 2009
- Robinson, M. D.; McCarthy, D. J.; Smyth, G. K.
- Bioinformatics, Vol. 26, Issue 1
Concentration and Photochemistry of PAHs, NPAHs, and OPAHs and Toxicity of PM 2.5 during the Beijing Olympic Games
journal, August 2011
- Wang, Wentao; Jariyasopit, Narumol; Schrlau, Jill
- Environmental Science & Technology, Vol. 45, Issue 16
HTSeq--a Python framework to work with high-throughput sequencing data
journal, September 2014
- Anders, S.; Pyl, P. T.; Huber, W.
- Bioinformatics, Vol. 31, Issue 2
Role of Arginase in Vessel Wall Remodeling
journal, January 2013
- Durante, William
- Frontiers in Immunology, Vol. 4
Comparative developmental toxicity of environmentally relevant oxygenated PAHs
journal, September 2013
- Knecht, Andrea L.; Goodale, Britton C.; Truong, Lisa
- Toxicology and Applied Pharmacology, Vol. 271, Issue 2
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure
journal, January 2012
- Mbewe-Campbell, Nzali; Wei, Zhiyun; Zhang, Kuixing
- Journal of Hypertension, Vol. 30, Issue 10
Stages of embryonic development of the zebrafish
journal, July 1995
- Kimmel, Charles B.; Ballard, William W.; Kimmel, Seth R.
- Developmental Dynamics, Vol. 203, Issue 3
Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator
journal, November 2007
- Evans, Brad R.; Karchner, Sibel I.; Allan, Lenka L.
- Molecular Pharmacology, Vol. 73, Issue 2
AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio)
journal, August 2011
- Van Tiem, Lindsey A.; Di Giulio, Richard T.
- Toxicology and Applied Pharmacology, Vol. 254, Issue 3
Atom/Fragment Contribution Method for Estimating Octanol–Water Partition Coefficients
journal, January 1995
- Meylan, William M.; Howard, Philip H.
- Journal of Pharmaceutical Sciences, Vol. 84, Issue 1
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
journal, November 2003
- Shannon, P.
- Genome Research, Vol. 13, Issue 11
Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols
journal, December 1996
- Durant, John L.; Busby, William F.; Lafleur, Arthur L.
- Mutation Research/Genetic Toxicology, Vol. 371, Issue 3-4
Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: Molecular characterization and occurrence
journal, May 2010
- Walgraeve, Christophe; Demeestere, Kristof; Dewulf, Jo
- Atmospheric Environment, Vol. 44, Issue 15
Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish
journal, February 2009
- Timme-Laragy, Alicia R.; Van Tiem, Lindsey A.; Linney, Elwood A.
- Toxicological Sciences, Vol. 109, Issue 2
Functional Analysis of OMICs Data and Small Molecule Compounds in an Integrated “Knowledge-Based” Platform
book, January 2009
- Nikolsky, Yuri; Kirillov, Eugene; Zuev, Roman
- Methods in Molecular Biology
Benzanthrone induced immunotoxicity via oxidative stress and inflammatory mediators in Balb/c mice
journal, March 2015
- Tewari, Prachi; Roy, Ruchi; Mishra, Sakshi
- Immunobiology, Vol. 220, Issue 3
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure
text, January 2012
- Hyung-Suk, Kim,; T., O’Connor, Daniel; S., Friese, Ryan
- The University of North Carolina at Chapel Hill University Libraries
Attenuation of Benzanthrone Toxicity by Ascorbic Acid in Guinea Pigs
journal, April 1994
- Das, M.
- Fundamental and Applied Toxicology, Vol. 22, Issue 3
Transformation of PAHs during ethanol-Fenton treatment of an aged gasworks’ soil
journal, November 2006
- Lundstedt, Staffan; Persson, Ylva; Öberg, Lars
- Chemosphere, Vol. 65, Issue 8
In Vivo and in Vitro Inhibition of CYP1A-Dependent Activity in Fundulus heteroclitus by the Polynuclear Aromatic Hydrocarbon Fluoranthene
journal, December 2001
- Willett, Kristine L.; Wassenberg, Deena; Lienesch, Laila
- Toxicology and Applied Pharmacology, Vol. 177, Issue 3
Regulation of Pulmonary and Hepatic Cytochrome P4501A Expression in the Rat by Hyperoxia: Implications for Hyperoxic Lung Injury
journal, March 2002
- Couroucli, Xanthi I.; Welty, Stephen E.; Geske, Robert S.
- Molecular Pharmacology, Vol. 61, Issue 3
Exposure to the JNK inhibitor SP600125 (anthrapyrazolone) during early zebrafish development results in morphological defects: Impact of SP600125 on zebrafish development
journal, July 2011
- Valesio, Eric G.; Zhang, Honghong; Zhang, Chunbo
- Journal of Applied Toxicology, Vol. 33, Issue 1
The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells
journal, November 2000
- Kim, Dong W.; Gazourian, Lee; Quadri, Shafat A.
- Oncogene, Vol. 19, Issue 48
Allergic contact dermatitis caused by benzanthrone in a pair of trousers: BENZANTHRONE AS CONTACT ALLERGEN
journal, June 2014
- Svedman, Cecilia; Zimerson, Erik; Bruze, Magnus
- Contact Dermatitis, Vol. 71, Issue 1
Genes and environment
book, February 2014
- Goldberg, David; Goodyer, Ian
- The Origins and Course of Common Mental Disorders
Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice
journal, January 2014
- Singh, Kameshwar P.; Bennett, John A.; Casado, Fanny L.
- Stem Cells and Development, Vol. 23, Issue 2
Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish
journal, September 2014
- Lanham, Kevin A.; Plavicki, Jessica; Peterson, Richard E.
- Toxicological Sciences, Vol. 141, Issue 1
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
journal, January 2008
- Beischlag, Timothy V.; Morales, J. Luis; Hollingshead, Brett D.
- Critical Reviews™ in Eukaryotic Gene Expression, Vol. 18, Issue 3
Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism
journal, December 2006
- Incardona, John P.; Day, Heather L.; Collier, Tracy K.
- Toxicology and Applied Pharmacology, Vol. 217, Issue 3
2,3,7,8-Tetrachlorodibenzo- p -dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium
journal, March 2010
- Planchart, Antonio; Mattingly, Carolyn J.
- Chemical Research in Toxicology, Vol. 23, Issue 3
Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development
journal, December 2011
- Incardona, John P.; Linbo, Tiffany L.; Scholz, Nathaniel L.
- Toxicology and Applied Pharmacology, Vol. 257, Issue 2
Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress.
journal, February 1994
- Barker, C. W.; Fagan, J. B.; Pasco, D. S.
- Journal of Biological Chemistry, Vol. 269, Issue 6
Activity regulates programmed cell death of zebrafish Rohon-Beard neurons
journal, September 2001
- Svoboda, Kurt R.; Linares, Alicia E.; Ribera, Angeles B.
- Development, Vol. 128, Issue 18
Works referencing / citing this record:
Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons
journal, November 2017
- Geier, Mitra C.; Chlebowski, Anna C.; Truong, Lisa
- Archives of Toxicology, Vol. 92, Issue 2
In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression
journal, April 2017
- Garcia, Gloria R.; Goodale, Britton C.; Wiley, Michelle W.
- Molecular Pharmacology, Vol. 91, Issue 6
Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard
journal, May 2019
- Shankar, Prarthana; Geier, Mitra C.; Truong, Lisa
- International Journal of Molecular Sciences, Vol. 20, Issue 10
Immobilization of P. stutzeri on Activated Carbons for Degradation of Hydrocarbons from Oil-in-Saltwater Emulsions
journal, April 2019
- Zapata Acosta, Karol; Carrasco-Marin, Francisco; Cortés, Farid
- Nanomaterials, Vol. 9, Issue 4
Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity
journal, January 2018
- Asnani, Aarti; Zheng, Bahoui; Liu, Yan
- JCI Insight, Vol. 3, Issue 1
Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard
journal, May 2019
- Shankar, Prarthana; Geier, Mitra C.; Truong, Lisa
- International Journal of Molecular Sciences, Vol. 20, Issue 10
Aconitine induces cardiotoxicity through regulation of calcium signaling pathway in zebrafish embryos and in H9c2 cells
journal, January 2020
- Li, Mengting; Xie, Xiaofang; Chen, Haimei
- Journal of Applied Toxicology, Vol. 40, Issue 6
Immobilization of P. stutzeri on Activated Carbons for Degradation of Hydrocarbons from Oil-in-Saltwater Emulsions
journal, April 2019
- Zapata Acosta, Karol; Carrasco-Marin, Francisco; Cortés, Farid
- Nanomaterials, Vol. 9, Issue 4
Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
journal, January 2016
- Wincent, Emma; Le Bihanic, Florane; Dreij, Kristian
- Toxicology Research, Vol. 5, Issue 3
AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish
journal, March 2018
- Garcia, Gloria R.; Bugel, Sean M.; Truong, Lisa
- PLOS ONE, Vol. 13, Issue 3
Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs
journal, February 2017
- Chlebowski, Anna C.; Garcia, Gloria R.; La Du, Jane K.
- Toxicological Sciences, Vol. 157, Issue 1
Mechanistic Evaluation of Benzo[a]pyrene’s Developmental Toxicities Mediated by Reduced Cyp19a1b Activity
journal, September 2016
- Alharthy, Khalid M.; Albaqami, Faisal F.; Thornton, Cammi
- Toxicological Sciences, Vol. 155, Issue 1
In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression
journal, April 2017
- Garcia, Gloria R.; Goodale, Britton C.; Wiley, Michelle W.
- Molecular Pharmacology, Vol. 91, Issue 6
AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish
journal, March 2018
- Garcia, Gloria R.; Bugel, Sean M.; Truong, Lisa
- PLOS ONE, Vol. 13, Issue 3
Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA ( slincR ) Using the Zebrafish Model
journal, November 2018
- Garcia, Gloria R.; Shankar, Prarthana; Dunham, Cheryl L.
- Environmental Health Perspectives, Vol. 126, Issue 11
Investigation of inflammation inducing substances in PM2.5 particles by an elimination method using thermal decomposition
journal, July 2019
- He, Miao; Ichinose, Takamichi; Ito, Tomohiro
- Environmental Toxicology, Vol. 34, Issue 10