The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance
Abstract
The proton-driven ATP synthase (FOF1) is comprised of two rotary, stepping motors (FO and F1) coupled by an elastic power transmission. The elastic compliance resides in the rotor module that includes the membrane-embedded FO c-ring. Proton transport by FO is firmly coupled to the rotation of the c-ring relative to other FO subunits (ab2). It drives ATP synthesis. We used a computational method to investigate the contribution of the c-ring to the total elastic compliance. We performed principal component analysis of conformational ensembles built using distance constraints from the bovine mitochondrial c-ring x-ray structure. Angular rotary twist, the dominant ring motion, was estimated to show that the c-ring accounted in part for the measured compliance. Ring rotation was entrained to rotation of the external helix within each hairpin-shaped c-subunit in the ring. Ensembles of monomer and dimers extracted from complete c-rings showed that the coupling between collective ring and the individual subunit motions was independent of the size of the c-ring, which varies between organisms. Molecular determinants were identified by covariance analysis of residue coevolution and structural-alphabet-based local dynamics correlations. The residue coevolution gave a readout of subunit architecture. The dynamic couplings revealed that the hinge for both ring andmore »
- Authors:
-
- Brunel Univ.London, Uxbridge, (United Kingdom). Department of Computer Science and Synthetic Biology Theme
- The Francis Crick Inst., London (United Kingdom). Mathematical Biology
- Univ. of Osnabruck (Germany). Dept. of Biophysics
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1213689
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biophysical Journal
- Additional Journal Information:
- Journal Volume: 109; Journal Issue: 5; Journal ID: ISSN 0006-3495
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Pandini, Alessandro, Kleinjung, Jens, Taylor, Willie R., Junge, Wolfgang, and Khan, Shahid. The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance. United States: N. p., 2015.
Web. doi:10.1016/j.bpj.2015.07.005.
Pandini, Alessandro, Kleinjung, Jens, Taylor, Willie R., Junge, Wolfgang, & Khan, Shahid. The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance. United States. https://doi.org/10.1016/j.bpj.2015.07.005
Pandini, Alessandro, Kleinjung, Jens, Taylor, Willie R., Junge, Wolfgang, and Khan, Shahid. Tue .
"The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance". United States. https://doi.org/10.1016/j.bpj.2015.07.005. https://www.osti.gov/servlets/purl/1213689.
@article{osti_1213689,
title = {The Phylogenetic Signature Underlying ATP Synthase c-Ring Compliance},
author = {Pandini, Alessandro and Kleinjung, Jens and Taylor, Willie R. and Junge, Wolfgang and Khan, Shahid},
abstractNote = {The proton-driven ATP synthase (FOF1) is comprised of two rotary, stepping motors (FO and F1) coupled by an elastic power transmission. The elastic compliance resides in the rotor module that includes the membrane-embedded FO c-ring. Proton transport by FO is firmly coupled to the rotation of the c-ring relative to other FO subunits (ab2). It drives ATP synthesis. We used a computational method to investigate the contribution of the c-ring to the total elastic compliance. We performed principal component analysis of conformational ensembles built using distance constraints from the bovine mitochondrial c-ring x-ray structure. Angular rotary twist, the dominant ring motion, was estimated to show that the c-ring accounted in part for the measured compliance. Ring rotation was entrained to rotation of the external helix within each hairpin-shaped c-subunit in the ring. Ensembles of monomer and dimers extracted from complete c-rings showed that the coupling between collective ring and the individual subunit motions was independent of the size of the c-ring, which varies between organisms. Molecular determinants were identified by covariance analysis of residue coevolution and structural-alphabet-based local dynamics correlations. The residue coevolution gave a readout of subunit architecture. The dynamic couplings revealed that the hinge for both ring and subunit helix rotations was constructed from the proton-binding site and the adjacent glycine motif (IB-GGGG) in the midmembrane plane. IB-GGGG motifs were linked by long-range couplings across the ring, while intrasubunit couplings connected the motif to the conserved cytoplasmic loop and adjacent segments. The correlation with principal collective motions shows that the couplings underlie both ring rotary and bending motions. Noncontact couplings between IB-GGGG motifs matched the coevolution signal as well as contact couplings. The residue coevolution reflects the physiological importance of the dynamics that may link proton transfer to ring compliance.},
doi = {10.1016/j.bpj.2015.07.005},
journal = {Biophysical Journal},
number = 5,
volume = 109,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2015},
month = {Tue Sep 01 00:00:00 EDT 2015}
}
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