Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions
Abstract
N-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869). Proteins containing a domain from this family can be found in most Bacteroides species and, in large numbers, in all human gut microbiome samples. Both BVU_4064 and BF1687 proteins have a consensus lipobox motif implying they are anchored to the membrane, but their functions are otherwise unknown. The C-terminal half of BVU_4064 is assigned to protein family PF12986 (DUF3870); the equivalent part of BF1687 was unclassified.
- Authors:
-
- Joint Center for Structural Genomics, San Diego, CA (United States); Sanford-Burnham Medical Research Inst., La Jolla, CA (United States)
- European Bioinformatics Inst., Cambridgeshire (United Kingdom). European Molecular Lab., Wellcome Trust Genome Campus
- Joint Center for Structural Genomics, San Diego, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
- National Library of Medicine, Bethesda, MD (United States)
- Publication Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1208934
- Grant/Contract Number:
- AC02-76SF00515
- Resource Type:
- Accepted Manuscript
- Journal Name:
- BMC Bioinformatics
- Additional Journal Information:
- Journal Volume: 16; Journal Issue: 1; Journal ID: ISSN 1471-2105
- Publisher:
- BioMed Central
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Natarajan, Padmaja, Punta, Marco, Kumar, Abhinav, Yeh, Andrew P, Godzik, Adam, and Aravind, L. Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions. United States: N. p., 2015.
Web. doi:10.1186/s12859-014-0434-7.
Natarajan, Padmaja, Punta, Marco, Kumar, Abhinav, Yeh, Andrew P, Godzik, Adam, & Aravind, L. Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions. United States. https://doi.org/10.1186/s12859-014-0434-7
Natarajan, Padmaja, Punta, Marco, Kumar, Abhinav, Yeh, Andrew P, Godzik, Adam, and Aravind, L. Fri .
"Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions". United States. https://doi.org/10.1186/s12859-014-0434-7. https://www.osti.gov/servlets/purl/1208934.
@article{osti_1208934,
title = {Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions},
author = {Natarajan, Padmaja and Punta, Marco and Kumar, Abhinav and Yeh, Andrew P and Godzik, Adam and Aravind, L.},
abstractNote = {N-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869). Proteins containing a domain from this family can be found in most Bacteroides species and, in large numbers, in all human gut microbiome samples. Both BVU_4064 and BF1687 proteins have a consensus lipobox motif implying they are anchored to the membrane, but their functions are otherwise unknown. The C-terminal half of BVU_4064 is assigned to protein family PF12986 (DUF3870); the equivalent part of BF1687 was unclassified.},
doi = {10.1186/s12859-014-0434-7},
journal = {BMC Bioinformatics},
number = 1,
volume = 16,
place = {United States},
year = {Fri Jan 16 00:00:00 EST 2015},
month = {Fri Jan 16 00:00:00 EST 2015}
}
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