Toward a science of tumor forecasting for clinical oncology
Abstract
We propose that the quantitative cancer biology community makes a concerted effort to apply lessons from weather forecasting to develop an analogous methodology for predicting and evaluating tumor growth and treatment response. Currently, the time course of tumor response is not predicted; instead, response is only assessed post hoc by physical examination or imaging methods. This fundamental practice within clinical oncology limits optimization of a treatment regimen for an individual patient, as well as to determine in real time whether the choice was in fact appropriate. This is especially frustrating at a time when a panoply of molecularly targeted therapies is available, and precision genetic or proteomic analyses of tumors are an established reality. By learning from the methods of weather and climate modeling, we submit that the forecasting power of biophysical and biomathematical modeling can be harnessed to hasten the arrival of a field of predictive oncology. Furthermore, with a successful methodology toward tumor forecasting, it should be possible to integrate large tumor-specific datasets of varied types and effectively defeat one cancer patient at a time.
- Authors:
-
- Vanderbilt Univ., Nashville, TN (United States). Inst. of Imaging Science; Dept. of Radiology and Radiological Sciences; Dept. of Biomedical Engineering; Dept. of Physics and Astronomy; Dept. of Cancer Biology; Vanderbilt-Ingram Cancer Center
- Vanderbilt Univ., Nashville, TN (United States). Dept. of Cancer Biology; Vanderbilt-Ingram Cancer Center
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computer Science and Mathematics Division
- Vanderbilt Univ., Nashville, TN (United States). Dept. of Physics and Astronomy
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1185639
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Cancer Research
- Additional Journal Information:
- Journal Volume: 75; Journal Issue: 6; Journal ID: ISSN 0008-5472
- Publisher:
- American Association for Cancer Research
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; nonlinear models of tumor growth; analogies to weather and climate forecasting
Citation Formats
Yankeelov, Thomas E., Quaranta, Vito, Evans, Katherine J., and Rericha, Erin C. Toward a science of tumor forecasting for clinical oncology. United States: N. p., 2015.
Web. doi:10.1158/0008-5472.CAN-14-2233.
Yankeelov, Thomas E., Quaranta, Vito, Evans, Katherine J., & Rericha, Erin C. Toward a science of tumor forecasting for clinical oncology. United States. https://doi.org/10.1158/0008-5472.CAN-14-2233
Yankeelov, Thomas E., Quaranta, Vito, Evans, Katherine J., and Rericha, Erin C. Sun .
"Toward a science of tumor forecasting for clinical oncology". United States. https://doi.org/10.1158/0008-5472.CAN-14-2233. https://www.osti.gov/servlets/purl/1185639.
@article{osti_1185639,
title = {Toward a science of tumor forecasting for clinical oncology},
author = {Yankeelov, Thomas E. and Quaranta, Vito and Evans, Katherine J. and Rericha, Erin C.},
abstractNote = {We propose that the quantitative cancer biology community makes a concerted effort to apply lessons from weather forecasting to develop an analogous methodology for predicting and evaluating tumor growth and treatment response. Currently, the time course of tumor response is not predicted; instead, response is only assessed post hoc by physical examination or imaging methods. This fundamental practice within clinical oncology limits optimization of a treatment regimen for an individual patient, as well as to determine in real time whether the choice was in fact appropriate. This is especially frustrating at a time when a panoply of molecularly targeted therapies is available, and precision genetic or proteomic analyses of tumors are an established reality. By learning from the methods of weather and climate modeling, we submit that the forecasting power of biophysical and biomathematical modeling can be harnessed to hasten the arrival of a field of predictive oncology. Furthermore, with a successful methodology toward tumor forecasting, it should be possible to integrate large tumor-specific datasets of varied types and effectively defeat one cancer patient at a time.},
doi = {10.1158/0008-5472.CAN-14-2233},
journal = {Cancer Research},
number = 6,
volume = 75,
place = {United States},
year = {Sun Mar 15 00:00:00 EDT 2015},
month = {Sun Mar 15 00:00:00 EDT 2015}
}
Web of Science
Works referencing / citing this record:
Translating preclinical MRI methods to clinical oncology
journal, March 2019
- Hormuth, David A.; Sorace, Anna G.; Virostko, John
- Journal of Magnetic Resonance Imaging, Vol. 50, Issue 5
Agent-Based Modeling of Cancer Stem Cell Driven Solid Tumor Growth
book, January 2016
- Poleszczuk, Jan; Macklin, Paul; Enderling, Heiko
- Stem Cell Heterogeneity
Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success
journal, July 2016
- Yankeelov, Thomas E.; An, Gary; Saut, Oliver
- Annals of Biomedical Engineering, Vol. 44, Issue 9
Calibrating a Predictive Model of Tumor Growth and Angiogenesis with Quantitative MRI
journal, April 2019
- Hormuth, David A.; Jarrett, Angela M.; Feng, Xinzeng
- Annals of Biomedical Engineering, Vol. 47, Issue 7
Predicting Patient-Specific Radiotherapy Protocols Based on Mathematical Model Choice for Proliferation Saturation Index
journal, July 2017
- Poleszczuk, Jan; Walker, Rachel; Moros, Eduardo G.
- Bulletin of Mathematical Biology, Vol. 80, Issue 5
The mathematics of cancer: integrating quantitative models
journal, November 2015
- Altrock, Philipp M.; Liu, Lin L.; Michor, Franziska
- Nature Reviews Cancer, Vol. 15, Issue 12
Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+ breast cancer
journal, September 2019
- Jarrett, Angela M.; Shah, Alay; Bloom, Meghan J.
- Scientific Reports, Vol. 9, Issue 1
Mathematical models of tumor cell proliferation: A review of the literature
journal, October 2018
- Jarrett, Angela M.; Lima, Ernesto A. B. F.; Hormuth, David A.
- Expert Review of Anticancer Therapy, Vol. 18, Issue 12
Incorporating drug delivery into an imaging-driven, mechanics-coupled reaction diffusion model for predicting the response of breast cancer to neoadjuvant chemotherapy: theory and preliminary clinical results
journal, May 2018
- Jarrett, Angela M.; Hormuth, David A.; Barnes, Stephanie L.
- Physics in Medicine & Biology, Vol. 63, Issue 10
The 2019 mathematical oncology roadmap
journal, June 2019
- Rockne, Russell C.; Hawkins-Daarud, Andrea; Swanson, Kristin R.
- Physical Biology, Vol. 16, Issue 4
Mathematical modelling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer
journal, September 2018
- Jarrett, Angela M.; Bloom, Meghan J.; Godfrey, Wesley
- Mathematical Medicine and Biology: A Journal of the IMA, Vol. 36, Issue 3
When, why and how clonal diversity predicts future tumour growth
posted_content, December 2019
- Noble, Robert; Burley, John T.; Sueur, Cécile Le
- bioRxiv
Agent-based modeling of cancer stem cell driven solid tumor growth
journal, December 2015
- Poleszczuk, Jan T.; Macklin, Paul; Enderling, Heiko
- Methods In Molecular Biology