Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit
Abstract
Using affinity purification and mass spectrometry, we identified the subunits of Arabidopsis thaliana multisubunit RNA Polymerases I and III (abbreviated as Pol I and Pol III), providing the first description of their physical compositions in plants. AC40 and AC19 subunits are typically common to Pol I (a.k.a. Pol A) and Pol III (a.k.a. Pol C) and are encoded by single genes whose mutation, in humans, is a cause of the craniofacial disorder, Treacher-Collins Syndrome. Surprisingly, A. thaliana, and related species, express two distinct AC40 paralogs, one of which assembles into Pol I and the other of which assembles into Pol III. Changes at eight amino acid positions correlate with this functional divergence of Pol I and Pol III-specific AC40 paralogs. Two genes encode homologs of the yeast C53 subunit, and either variant can assemble into Pol III. By contrast, only one of two potential C17 variants, and one of two potential C31 variants were detected in Pol III. We introduce a new nomenclature system for plant Pol I and Pol III subunits in which the twelve subunits that are structurally and functionally homologous among Pols I through V are assigned equivalent numbers.
- Authors:
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1182913
- Report Number(s):
- PNNL-SA-108415
Journal ID: ISSN 0305-1048; 48378; 44640; KP1704020
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nucleic Acids Research
- Additional Journal Information:
- Journal Volume: 43; Journal Issue: 8; Journal ID: ISSN 0305-1048
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Environmental Molecular Sciences Laboratory
Citation Formats
Ream, Thomas S., Haag, Jeremy R., Pontvianne, Frederic, Nicora, Carrie D., Norbeck, Angela D., Pasa-Tolic, Ljiljana, and Pikaard, Craig S. Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit. United States: N. p., 2015.
Web. doi:10.1093/nar/gkv247.
Ream, Thomas S., Haag, Jeremy R., Pontvianne, Frederic, Nicora, Carrie D., Norbeck, Angela D., Pasa-Tolic, Ljiljana, & Pikaard, Craig S. Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit. United States. https://doi.org/10.1093/nar/gkv247
Ream, Thomas S., Haag, Jeremy R., Pontvianne, Frederic, Nicora, Carrie D., Norbeck, Angela D., Pasa-Tolic, Ljiljana, and Pikaard, Craig S. Sat .
"Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit". United States. https://doi.org/10.1093/nar/gkv247. https://www.osti.gov/servlets/purl/1182913.
@article{osti_1182913,
title = {Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III-specific forms of the AC40 subunit and alternative forms of the C53 subunit},
author = {Ream, Thomas S. and Haag, Jeremy R. and Pontvianne, Frederic and Nicora, Carrie D. and Norbeck, Angela D. and Pasa-Tolic, Ljiljana and Pikaard, Craig S.},
abstractNote = {Using affinity purification and mass spectrometry, we identified the subunits of Arabidopsis thaliana multisubunit RNA Polymerases I and III (abbreviated as Pol I and Pol III), providing the first description of their physical compositions in plants. AC40 and AC19 subunits are typically common to Pol I (a.k.a. Pol A) and Pol III (a.k.a. Pol C) and are encoded by single genes whose mutation, in humans, is a cause of the craniofacial disorder, Treacher-Collins Syndrome. Surprisingly, A. thaliana, and related species, express two distinct AC40 paralogs, one of which assembles into Pol I and the other of which assembles into Pol III. Changes at eight amino acid positions correlate with this functional divergence of Pol I and Pol III-specific AC40 paralogs. Two genes encode homologs of the yeast C53 subunit, and either variant can assemble into Pol III. By contrast, only one of two potential C17 variants, and one of two potential C31 variants were detected in Pol III. We introduce a new nomenclature system for plant Pol I and Pol III subunits in which the twelve subunits that are structurally and functionally homologous among Pols I through V are assigned equivalent numbers.},
doi = {10.1093/nar/gkv247},
journal = {Nucleic Acids Research},
number = 8,
volume = 43,
place = {United States},
year = {Sat May 02 00:00:00 EDT 2015},
month = {Sat May 02 00:00:00 EDT 2015}
}
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Functional Consequences of Subunit Diversity in RNA Polymerases II and V
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Prokaryotic and eukaryotic RNA polymerases have homologous core subunits.
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SHH1, a Homeodomain Protein Required for DNA Methylation, As Well As RDR2, RDM4, and Chromatin Remodeling Factors, Associate with RNA Polymerase IV
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The role of long non-coding RNA in transcriptional gene silencing
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Functional Diversification of Maize RNA Polymerase IV and V Subtypes via Alternative Catalytic Subunits
journal, October 2014
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The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination
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An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II
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The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation
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Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II
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Treacle recruits RNA polymerase I complex to the nucleolus that is independent of UBF
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- Proceedings of the National Academy of Sciences, Vol. 99, Issue 23
SAD1, an RNA polymerase I subunit A34.5 of rice, interacts with Mediator and controls various aspects of plant development
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RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability
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