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Title: Rapid determination of 226Ra in emergency urine samples

Abstract

A new method has been developed at the Savannah River National Laboratory (SRNL) that can be used for the rapid determination of 226Ra in emergency urine samples following a radiological incident. If a radiological dispersive device event or a nuclear accident occurs, there will be an urgent need for rapid analyses of radionuclides in urine samples to ensure the safety of the public. Large numbers of urine samples will have to be analyzed very quickly. This new SRNL method was applied to 100 mL urine aliquots, however this method can be applied to smaller or larger sample aliquots as needed. The method was optimized for rapid turnaround times; urine samples may be prepared for counting in <3 h. A rapid calcium phosphate precipitation method was used to pre-concentrate 226Ra from the urine sample matrix, followed by removal of calcium by cation exchange separation. A stacked elution method using DGA Resin was used to purify the 226Ra during the cation exchange elution step. This approach combines the cation resin elution step with the simultaneous purification of 226Ra with DGA Resin, saving time. 133Ba was used instead of 225Ra as tracer to allow immediate counting; however, 225Ra can still be used asmore » an option. The rapid purification of 226Ra to remove interferences using DGA Resin was compared with a slightly longer Ln Resin approach. A final barium sulfate micro-precipitation step was used with isopropanol present to reduce solubility; producing alpha spectrometry sources with peaks typically <40 keV FWHM (full width half max). This new rapid method is fast, has very high tracer yield (>90 %), and removes interferences effectively. The sample preparation method can also be adapted to ICP-MS measurement of 226Ra, with rapid removal of isobaric interferences.« less

Authors:
 [1];  [1];  [1];  [1];  [2]
+ Show Author Affiliations
  1. Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)
  2. PG Research Foundation Inc., Lisle, IL (United States)
Publication Date:
Research Org.:
Savannah River Site (SRS), Aiken, SC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1159456
Report Number(s):
SRNL-STI-2014-00090
Journal ID: ISSN 0236-5731
Grant/Contract Number:  
AC09-08SR22470
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Radioanalytical and Nuclear Chemistry
Additional Journal Information:
Journal Volume: 300; Journal Issue: 3; Journal ID: ISSN 0236-5731
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION; 61 RADIATION PROTECTION AND DOSIMETRY

Citation Formats

Maxwell, Sherrod L., Culligan, Brian K., Hutchison, Jay B., Utsey, Robin C., and McAlister, Daniel R. Rapid determination of 226Ra in emergency urine samples. United States: N. p., 2014. Web. doi:10.1007/s10967-014-3046-9.
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Maxwell, Sherrod L., Culligan, Brian K., Hutchison, Jay B., Utsey, Robin C., & McAlister, Daniel R. Rapid determination of 226Ra in emergency urine samples. United States. https://doi.org/10.1007/s10967-014-3046-9
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Maxwell, Sherrod L., Culligan, Brian K., Hutchison, Jay B., Utsey, Robin C., and McAlister, Daniel R. Thu . "Rapid determination of 226Ra in emergency urine samples". United States. https://doi.org/10.1007/s10967-014-3046-9. https://www.osti.gov/servlets/purl/1159456.
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@article{osti_1159456,
title = {Rapid determination of 226Ra in emergency urine samples},
author = {Maxwell, Sherrod L. and Culligan, Brian K. and Hutchison, Jay B. and Utsey, Robin C. and McAlister, Daniel R.},
abstractNote = {A new method has been developed at the Savannah River National Laboratory (SRNL) that can be used for the rapid determination of 226Ra in emergency urine samples following a radiological incident. If a radiological dispersive device event or a nuclear accident occurs, there will be an urgent need for rapid analyses of radionuclides in urine samples to ensure the safety of the public. Large numbers of urine samples will have to be analyzed very quickly. This new SRNL method was applied to 100 mL urine aliquots, however this method can be applied to smaller or larger sample aliquots as needed. The method was optimized for rapid turnaround times; urine samples may be prepared for counting in <3 h. A rapid calcium phosphate precipitation method was used to pre-concentrate 226Ra from the urine sample matrix, followed by removal of calcium by cation exchange separation. A stacked elution method using DGA Resin was used to purify the 226Ra during the cation exchange elution step. This approach combines the cation resin elution step with the simultaneous purification of 226Ra with DGA Resin, saving time. 133Ba was used instead of 225Ra as tracer to allow immediate counting; however, 225Ra can still be used as an option. The rapid purification of 226Ra to remove interferences using DGA Resin was compared with a slightly longer Ln Resin approach. A final barium sulfate micro-precipitation step was used with isopropanol present to reduce solubility; producing alpha spectrometry sources with peaks typically <40 keV FWHM (full width half max). This new rapid method is fast, has very high tracer yield (>90 %), and removes interferences effectively. The sample preparation method can also be adapted to ICP-MS measurement of 226Ra, with rapid removal of isobaric interferences.},
doi = {10.1007/s10967-014-3046-9},
journal = {Journal of Radioanalytical and Nuclear Chemistry},
number = 3,
volume = 300,
place = {United States},
year = {Thu Feb 27 00:00:00 EST 2014},
month = {Thu Feb 27 00:00:00 EST 2014}
}
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Journal Article:
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Publisher's Version of Record
https://doi.org/10.1007/s10967-014-3046-9
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Works referenced in this record:

An emergency radiobioassay method for 226Ra in human urine samples
journal, November 2011

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Determination of 226Ra in urine samples by Q-ICP-MS: A method for routine analyses
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Rapid determination of 226Ra in urine samples
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Chromatographic generator systems for the actinides and natural decay series elements
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