Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways
Abstract
One aim for an HIV vaccine is to elicit neutralizing antibodies (Nab) that can limit replication of genetically diverse viruses and prevent establishment of a new infection. Thus, identifying the strengths and weaknesses of Nab during the early stages of natural infection could prove useful in achieving this goal. Here we demonstrate that viral escape readily occurred despite the development of high titer autologous Nab in two subjects with acute/early subtype C infection. To provide a detailed portrayal of the escape pathways, Nab resistant variants identified at multiple time points were used to create a series of envelope (Env) glycoprotein chimeras and mutants within the background of a corresponding newly transmitted Env. In one subject, Nab escape was driven predominantly by changes in the region of gp120 that extends from the beginning of the V3 domain to the end of the V5 domain (V3V5). However, Nab escape pathways in this subject oscillated and at times required cooperation between V1V2 and the gp41 ectodomain. In the second subject, escape was driven by changes in V1V2. This V1V2-dependent escape pathway was retained over time, and its utility was reflected in the virus’s ability to escape from two distinct monoclonal antibodies (Mabs) derivedmore »
- Authors:
-
- Emory University, Atlanta, GA (United States)
- Zambia Emory HIV Research Project, ZEHRP, Lusaka (Zambia); Zambia Blood Transfusion Service, Lusaka (Zambia)
- Zambia Emory HIV Research Project, ZEHRP, Lusaka (Zambia); Emory University, Atlanta, GA (United States)
- Public Health Research Institute., Newark, NJ (United States); University of Medicine and Dentistry, Newark, NJ (United States)
- University of Alabama, Birmingham, AL (United States)
- Tulane University, New Orleans, LA (United States)
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); Bill and Melinda Gates Foundation
- OSTI Identifier:
- 1627894
- Grant/Contract Number:
- AC52-06NA25396; R01-AI58706; R01-AI51231; U01-AI78410; 37874; 38619
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Pathogens
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 9; Journal ID: ISSN 1553-7374
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; HIV-1; glycosylation; hybridomas; protein sequencing; B cells; cloning; DNA cloning; polymerase chain reaction
Citation Formats
Rong, Rong, Li, Bing, Lynch, Rebecca M., Haaland, Richard E., Murphy, Megan K., Mulenga, Joseph, Allen, Susan A., Pinter, Abraham, Shaw, George M., Hunter, Eric, Robinson, James E., Gnanakaran, S., and Derdeyn, Cynthia A. Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways. United States: N. p., 2009.
Web. doi:10.1371/journal.ppat.1000594.
Rong, Rong, Li, Bing, Lynch, Rebecca M., Haaland, Richard E., Murphy, Megan K., Mulenga, Joseph, Allen, Susan A., Pinter, Abraham, Shaw, George M., Hunter, Eric, Robinson, James E., Gnanakaran, S., & Derdeyn, Cynthia A. Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways. United States. https://doi.org/10.1371/journal.ppat.1000594
Rong, Rong, Li, Bing, Lynch, Rebecca M., Haaland, Richard E., Murphy, Megan K., Mulenga, Joseph, Allen, Susan A., Pinter, Abraham, Shaw, George M., Hunter, Eric, Robinson, James E., Gnanakaran, S., and Derdeyn, Cynthia A. Fri .
"Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways". United States. https://doi.org/10.1371/journal.ppat.1000594. https://www.osti.gov/servlets/purl/1627894.
@article{osti_1627894,
title = {Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways},
author = {Rong, Rong and Li, Bing and Lynch, Rebecca M. and Haaland, Richard E. and Murphy, Megan K. and Mulenga, Joseph and Allen, Susan A. and Pinter, Abraham and Shaw, George M. and Hunter, Eric and Robinson, James E. and Gnanakaran, S. and Derdeyn, Cynthia A.},
abstractNote = {One aim for an HIV vaccine is to elicit neutralizing antibodies (Nab) that can limit replication of genetically diverse viruses and prevent establishment of a new infection. Thus, identifying the strengths and weaknesses of Nab during the early stages of natural infection could prove useful in achieving this goal. Here we demonstrate that viral escape readily occurred despite the development of high titer autologous Nab in two subjects with acute/early subtype C infection. To provide a detailed portrayal of the escape pathways, Nab resistant variants identified at multiple time points were used to create a series of envelope (Env) glycoprotein chimeras and mutants within the background of a corresponding newly transmitted Env. In one subject, Nab escape was driven predominantly by changes in the region of gp120 that extends from the beginning of the V3 domain to the end of the V5 domain (V3V5). However, Nab escape pathways in this subject oscillated and at times required cooperation between V1V2 and the gp41 ectodomain. In the second subject, escape was driven by changes in V1V2. This V1V2-dependent escape pathway was retained over time, and its utility was reflected in the virus’s ability to escape from two distinct monoclonal antibodies (Mabs) derived from this same patient via introduction of a single potential N-linked glycosylation site in V2. Spatial representation of the sequence changes in gp120 suggested that selective pressure acted upon the same regions of Env in these two subjects, even though the Env domains that drove escape were different. Together the findings argue that a single mutational pathway is not sufficient to confer escape in early subtype C HIV-1 infection, and support a model in which multiple strategies, including potential glycan shifts, direct alteration of an epitope sequence, and cooperative Env domain conformational masking, are used to evade neutralization.},
doi = {10.1371/journal.ppat.1000594},
journal = {PLoS Pathogens},
number = 9,
volume = 5,
place = {United States},
year = {Fri Sep 18 00:00:00 EDT 2009},
month = {Fri Sep 18 00:00:00 EDT 2009}
}
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Works referenced in this record:
Autologous HIV-1 Neutralizing Antibodies: Emergence of Neutralization-Resistant Escape Virus and Subsequent Development of Escape Virus Neutralizing Antibodies
journal, January 1992
- Arendrup, Maiken; Nielsen, Claus; Hansen, John-Erik Stig
- JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 5, Issue 3
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
text, January 2008
- F., Haynes, B.; T., Lucas, J.; D., Tomaras, G.
- The University of North Carolina at Chapel Hill University Libraries
Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma.
journal, February 2009
- Davis, K. L.
- Journal of Virology, Vol. 83, Issue 3, p. 1240-1259
Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing
journal, February 2008
- Salazar-Gonzalez, J. F.; Bailes, E.; Pham, K. T.
- Journal of Virology, Vol. 82, Issue 8
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
journal, July 2004
- Traggiai, Elisabetta; Becker, Stephan; Subbarao, Kanta
- Nature Medicine, Vol. 10, Issue 8
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
journal, June 1998
- Kwong, Peter D.; Wyatt, Richard; Robinson, James
- Nature, Vol. 393, Issue 6686
Role of V1V2 and Other Human Immunodeficiency Virus Type 1 Envelope Domains in Resistance to Autologous Neutralization during Clade C Infection
journal, November 2007
- Rong, Rong; Bibollet-Ruche, Frederic; Mulenga, Joseph
- Journal of Virology, Vol. 81, Issue 22
Development of the antibody response in acute HIV-1 infection
journal, January 2004
- Aasa-Chapman, Marlén MI; Hayman, Anna; Newton, Philippa
- AIDS, Vol. 18, Issue 3
Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India
journal, March 2009
- Kulkarni, Smita S.; Lapedes, Alan; Tang, Haili
- Virology, Vol. 385, Issue 2
Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates
journal, February 2001
- Kwong, Peter D.; Wyatt, Richard; Majeed, Shahzad
- Structure, Vol. 9, Issue 2
Genetic and Neutralization Properties of Subtype C Human Immunodeficiency Virus Type 1 Molecular env Clones from Acute and Early Heterosexually Acquired Infections in Southern Africa
journal, September 2006
- Li, M.; Salazar-Gonzalez, J. F.; Derdeyn, C. A.
- Journal of Virology, Vol. 80, Issue 23
Understanding and making use of human memory B cells
journal, June 2006
- Lanzavecchia, Antonio; Bernasconi, Nadia; Traggiai, Elisabetta
- Immunological Reviews, Vol. 211, Issue 1
A longitudinal assessment of autologous neutralizing antibodies in children perinatally infected with human immunodeficiency virus type 1
journal, June 2003
- Geffin, Rebeca; Hutto, Cecelia; Andrew, Carole
- Virology, Vol. 310, Issue 2
Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response
journal, February 2009
- Laird, Melissa E.; Igarashi, Tatsuhiko; Martin, Malcolm A.
- Journal of Virology, Vol. 83, Issue 4
Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission
journal, March 2004
- Derdeyn, C. A.
- Science, Vol. 303, Issue 5666
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004
journal, January 2006
- Hemelaar, Joris; Gouws, Eleanor; Ghys, Peter D.
- AIDS, Vol. 20, Issue 16
Rapid evolution of the neutralizing antibody response to HIV type 1 infection
journal, March 2003
- Richman, D. D.; Wrin, T.; Little, S. J.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 7
Molecular architecture of native HIV-1 gp120 trimers
journal, July 2008
- Liu, Jun; Bartesaghi, Alberto; Borgnia, Mario J.
- Nature, Vol. 455, Issue 7209
Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins
journal, November 2007
- Patel, Milloni B.; Hoffman, Noah G.; Swanstrom, Ronald
- Journal of Virology, Vol. 82, Issue 2
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
journal, October 2008
- Tomaras, G. D.; Yates, N. L.; Liu, P.
- Journal of Virology, Vol. 82, Issue 24, p. 12449-12463
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III
journal, May 1985
- Allan, J.; Coligan, J.; Barin, F.
- Science, Vol. 228, Issue 4703
Clade-Specific Differences between Human Immunodeficiency Virus Type 1 Clades B and C: Diversity and Correlations in C3-V4 Regions of gp120
journal, May 2007
- Gnanakaran, S.; Lang, Dorothy; Daniels, Marcus
- Journal of Virology, Vol. 81, Issue 9
Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients
journal, May 1985
- Barin, F.; McLane, M.; Allan, J.
- Science, Vol. 228, Issue 4703
Antibody neutralization and escape by HIV-1
journal, March 2003
- Wei, Xiping; Decker, Julie M.; Wang, Shuyi
- Nature, Vol. 422, Issue 6929
Appreciating HIV Type 1 Diversity: Subtype Differences in Env
journal, March 2009
- Lynch, Rebecca M.; Shen, Tongye; Gnanakaran, S.
- AIDS Research and Human Retroviruses, Vol. 25, Issue 3
Antigenic conservation and immunogenicity of the HIV coreceptor binding site
journal, May 2005
- Decker, Julie M.; Bibollet-Ruche, Frederic; Wei, Xiping
- The Journal of Experimental Medicine, Vol. 201, Issue 9
Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing
text, January 2008
- B., Guffey, M.; A., Anderson, J.; M., Korber, B. T.
- The University of North Carolina at Chapel Hill University Libraries
Determinants of Neutralization Resistance in the Envelope Glycoproteins of a Simian-Human Immunodeficiency Virus Passaged In Vivo
journal, October 1999
- Etemad-Moghadam, Bijan; Sun, Ying; Nicholson, Emma K.
- Journal of Virology, Vol. 73, Issue 10
Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates
journal, December 2000
- Kwong, Peter D.; Wyatt, Richard; Majeed, Shahzad
- Structure, Vol. 8, Issue 12
Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza
journal, May 2007
- Simmons, Cameron P.; Bernasconi, Nadia L.; Suguitan, Amorsolo L.
- PLoS Medicine, Vol. 4, Issue 5
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
journal, December 2002
- Kwong, Peter D.; Doyle, Michael L.; Casper, David J.
- Nature, Vol. 420, Issue 6916
Structure of an unliganded simian immunodeficiency virus gp120 core
journal, February 2005
- Chen, Bing; Vogan, Erik M.; Gong, Haiyun
- Nature, Vol. 433, Issue 7028
High frequencies of antibody responses to CD4 induced epitopes in HIV infected patients started on HAART during acute infection
journal, May 2006
- Robinson, James E.; Elliott, Debra Holton; Martin, Effie A.
- Human Antibodies, Vol. 14, Issue 3-4
Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1
journal, January 2009
- Haaland, Richard E.; Hawkins, Paulina A.; Salazar-Gonzalez, Jesus
- PLoS Pathogens, Vol. 5, Issue 1
Characterization of CD4-Induced Epitopes on the HIV Type 1 gp120 Envelope Glycoprotein Recognized by Neutralizing Human Monoclonal Antibodies
journal, November 2002
- Xiang, Shi-Hua; Doka, Najah; Choudhary, Rabeéa K.
- AIDS Research and Human Retroviruses, Vol. 18, Issue 16
Identification of Conserved and Variant Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 by Human Monoclonal Antibodies Produced by EBV-Transformed Cell Lines
journal, May 1990
- Robinson, James E.; Holton, Debra; Pacheco-Morell, Susan
- AIDS Research and Human Retroviruses, Vol. 6, Issue 5
The V1/V2 Domain of gp120 Is a Global Regulator of the Sensitivity of Primary Human Immunodeficiency Virus Type 1 Isolates to Neutralization by Antibodies Commonly Induced upon Infection
journal, April 2004
- Pinter, A.; Honnen, W. J.; He, Y.
- Journal of Virology, Vol. 78, Issue 10
A role for carbohydrates in immune evasion in AIDS
journal, June 1998
- Reitter, Julie N.; Means, Robert E.; Desrosiers, Ronald C.
- Nature Medicine, Vol. 4, Issue 6
Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins
text, January 2008
- G., Hoffman, N.; B., Patel, M.; R., Swanstrom,
- The University of North Carolina at Chapel Hill University Libraries
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
text, January 2008
- F., Keele, Brandon; B., Hicks, Charles; T., Lucas, Judith
- The University of North Carolina at Chapel Hill University Libraries
The Challenge of HIV-1 Subtype Diversity
journal, October 2008
- Taylor, Barbara S.; Hammer, Scott M.
- New England Journal of Medicine, Vol. 359, Issue 18
Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection
journal, April 2007
- Gray, E. S.; Moore, P. L.; Choge, I. A.
- Journal of Virology, Vol. 81, Issue 12
Selection for Neutralization Resistance of the Simian/Human Immunodeficiency Virus SHIVSF33A Variant In Vivo by Virtue of Sequence Changes in the Extracellular Envelope Glycoprotein That Modify N-Linked Glycosylation
journal, July 1999
- Cheng-Mayer, Cecilia; Brown, Amanda; Harouse, Janet
- Journal of Virology, Vol. 73, Issue 7
Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodies.
journal, January 1997
- Chackerian, B.; Rudensey, L. M.; Overbaugh, J.
- Journal of virology, Vol. 71, Issue 10
The Challenge of HIV-1 Subtype Diversity
journal, April 2008
- Taylor, Barbara S.; Sobieszczyk, Magdalena E.; McCutchan, Francine E.
- New England Journal of Medicine, Vol. 358, Issue 15
Unique Mutational Patterns in the Envelope α2 Amphipathic Helix and Acquisition of Length in gp120 Hypervariable Domains Are Associated with Resistance to Autologous Neutralization of Subtype C Human Immunodeficiency Virus Type 1
journal, March 2007
- Rong, Rong; Gnanakaran, S.; Decker, Julie M.
- Journal of Virology, Vol. 81, Issue 11
Characterization of Immune Escape Viruses from a Macaque Immunized with Live-Virus Vaccine and Challenged with Pathogenic SHIV KU-1
journal, October 2000
- Stipp, Heather L.; Kumar, Anil; Narayan, Opendra
- AIDS Research and Human Retroviruses, Vol. 16, Issue 15
Evidence for Potent Autologous Neutralizing Antibody Titers and Compact Envelopes in Early Infection with Subtype C Human Immunodeficiency Virus Type 1
journal, June 2006
- Li, Bing; Decker, Julie M.; Johnson, Roy W.
- Journal of Virology, Vol. 80, Issue 11
Antigenic Variation of SIV: Mutations in V4 Alter the Neutralization Profile
journal, July 1996
- Kinsey, Nicole E.; Anderson, Mark G.; Unangst, Tami J.
- Virology, Vol. 221, Issue 1
Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains
journal, October 2003
- Xiang, Shi-Hua; Wang, Liping; Abreu, Mariam
- Virology, Vol. 315, Issue 1
Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection
journal, June 2008
- Bunnik, E. M.; Pisas, L.; van Nuenen, A. C.
- Journal of Virology, Vol. 82, Issue 16
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
journal, December 2005
- Frost, S. D. W.; Wrin, T.; Smith, D. M.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 51
Changes in the Extracellular Envelope Glycoprotein of Variants That Evolve during the Course of Simian Immunodeficiency Virus SIVMne Infection Affect Neutralizing Antibody Recognition, Syncytium Formation, and Macrophage Tropism but Not Replication, Cytopathicity, or CCR-5 Coreceptor Recognition
journal, January 1998
- Rudensey, Lyle M.; Kimata, Jason T.; Long, E. Michelle
- Journal of Virology, Vol. 72, Issue 1
The C3-V4 Region Is a Major Target of Autologous Neutralizing Antibodies in Human Immunodeficiency Virus Type 1 Subtype C Infection
journal, December 2007
- Moore, Penny L.; Gray, Elin S.; Choge, Isaac A.
- Journal of Virology, Vol. 82, Issue 4
Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response
journal, September 2008
- Laird, Melissa E.; Igarashi, Tatsuhiko; Martin, Malcolm A.
- Journal of Virology, Vol. 82, Issue 22
Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.
journal, December 2008
- Binley, J. M.
- Journal of Virology, Vol. 82, Issue 23, p. 11651-11668
Structural definition of a conserved neutralization epitope on HIV-1 gp120
journal, February 2007
- Zhou, Tongqing; Xu, Ling; Dey, Barna
- Nature, Vol. 445, Issue 7129
Evidence for Potent Autologous Neutralizing Antibody Titers and Compact Envelopes in Early Infection with Subtype C Human Immunodeficiency Virus Type 1
journal, November 2007
- Li, Bing; Decker, Julie M.; Johnson, Roy W.
- Journal of Virology, Vol. 81, Issue 22
Human Immunodeficiency Virus Type 2 (HIV-2)/HIV-1 Envelope Chimeras Detect High Titers of Broadly Reactive HIV-1 V3-Specific Antibodies in Human Plasma
journal, November 2008
- Davis, Katie L.; Bibollet-Ruche, Frederic; Li, Hui
- Journal of Virology, Vol. 83, Issue 3
Role of V1V2 and Other Human Immunodeficiency Virus Type 1 Envelope Domains in Resistance to Autologous Neutralization during Clade C Infection
journal, November 2006
- Rong, Rong; Bibollet-Ruche, Frederic; Mulenga, Joseph
- Journal of Virology, Vol. 81, Issue 3
Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera
journal, January 1990
- Albert, Jan; Abrahamsson, Bengt; Nagy, Karoly
- AIDS, Vol. 4, Issue 2
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journal, April 2018
- Ita, Sergio; Hill, Alison K.; Lam, Evan C.
- Journal of Virology, Vol. 92, Issue 7
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
text, January 2013
- Lacerda, Miguel; Moore, Penny; Ngandu, Nobubelo
- Columbia University
Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes
journal, June 2015
- Peters, Paul J.; Gonzalez-Perez, Maria Paz; Musich, Thomas
- Retrovirology, Vol. 12, Issue 1
Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies
journal, August 2018
- Otsuka, Yuka; Schmitt, Kimberly; Quinlan, Brian D.
- PLOS Pathogens, Vol. 14, Issue 8
Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity
journal, October 2016
- VanBlargan, Laura A.; Goo, Leslie; Pierson, Theodore C.
- Microbiology and Molecular Biology Reviews, Vol. 80, Issue 4
Antibody Selection and Amino acid Reversions: Antibody Selection
journal, May 2012
- Silva, Jack da
- Evolution, Vol. 66, Issue 10
Structure–function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design
journal, July 2010
- Zolla-Pazner, Susan; Cardozo, Timothy
- Nature Reviews Immunology, Vol. 10, Issue 7
Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants
journal, January 2019
- Burton, Samantha; Spicer, Lori M.; Charles, Tysheena P.
- Journal of Virology, Vol. 93, Issue 7
A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo
journal, August 2010
- Riddick, Nadeene E.; Hermann, Emilia A.; Loftin, Lamorris M.
- PLoS Pathogens, Vol. 6, Issue 8
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
text, January 2011
- Gray, Elin S.; Madiga, Maphuti C.; Hermanus, Tandile
- Columbia University
Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
journal, August 2012
- O'Rourke, S. M.; Schweighardt, B.; Phung, P.
- Journal of Virology, Vol. 86, Issue 22
Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1
journal, August 2014
- Sather, D. N.; Carbonetti, S.; Malherbe, D. C.
- Journal of Virology, Vol. 88, Issue 22
Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens
journal, March 2016
- Hessell, Ann J.; Malherbe, Delphine C.; Pissani, Franco
- The Journal of Immunology, Vol. 196, Issue 7
Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
journal, December 2018
- Mabvakure, Batsirai M.; Scheepers, Cathrine; Garrett, Nigel
- Journal of Virology, Vol. 93, Issue 6
Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop
journal, January 2016
- Patil, Shilpa; Kumar, Rajesh; Deshpande, Suprit
- Journal of Virology, Vol. 90, Issue 7
Unique Phenotypic Characteristics of Recently Transmitted HIV-1 Subtype C Envelope Glycoprotein gp120: Use of CXCR6 Coreceptor by Transmitted Founder Viruses
journal, February 2018
- Ashokkumar, Manickam; Aralaguppe, Shambhu G.; Tripathy, Srikanth P.
- Journal of Virology, Vol. 92, Issue 9
Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape
journal, May 2012
- Bar, Katharine J.; Tsao, Chun-yen; Iyer, Shilpa S.
- PLoS Pathogens, Vol. 8, Issue 5
Recurrent Signature Patterns in HIV-1 B Clade Envelope Glycoproteins Associated with either Early or Chronic Infections
journal, September 2011
- Gnanakaran, S.; Bhattacharya, Tanmoy; Daniels, Marcus
- PLoS Pathogens, Vol. 7, Issue 9
Characterization of Acute HIV-1 Infection in High-Risk Nigerian Populations
journal, February 2012
- Charurat, Man; Nasidi, Abdulsalami; Delaney, Kevin
- The Journal of Infectious Diseases, Vol. 205, Issue 8
Previously Transmitted HIV-1 Strains Are Preferentially Selected During Subsequent Sexual Transmissions
journal, November 2012
- Redd, Andrew D.; Collinson-Streng, Aleisha N.; Chatziandreou, Nikolaos
- The Journal of Infectious Diseases, Vol. 206, Issue 9
R5 Clade C SHIV Strains with Tier 1 or 2 Neutralization Sensitivity: Tools to Dissect Env Evolution and to Develop AIDS Vaccines in Primate Models
journal, July 2010
- Siddappa, Nagadenahalli B.; Watkins, Jennifer D.; Wassermann, Klemens J.
- PLoS ONE, Vol. 5, Issue 7
HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds
journal, July 2016
- van den Kerkhof, Tom L. G. M.; de Taeye, Steven W.; Boeser-Nunnink, Brigitte D.
- Retrovirology, Vol. 13, Issue 1
HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth
journal, November 2018
- van Schooten, Jelle; van Gils, Marit J.
- Retrovirology, Vol. 15, Issue 1
Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
journal, July 2019
- Stefic, Karl; Bouvin-Pley, Mélanie; Braibant, Martine
- Vaccines, Vol. 7, Issue 3
Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 Recipients
journal, January 2015
- Yue, Ling; Pfafferott, Katja J.; Baalwa, Joshua
- PLoS Pathogens, Vol. 11, Issue 1
HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
journal, January 2011
- Cicala, Claudia; Arthos, James; Fauci, Anthony S.
- Journal of Translational Medicine, Vol. 9, Issue S1
The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission
journal, February 2011
- Nawaz, Fatima; Cicala, Claudia; Van Ryk, Donald
- PLoS Pathogens, Vol. 7, Issue 2
Antibody responses to envelope glycoproteins in HIV-1 infection
journal, May 2015
- Burton, Dennis R.; Mascola, John R.
- Nature Immunology, Vol. 16, Issue 6
Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate
journal, January 2013
- Narayan, Kristin M.; Agrawal, Nitish; Du, Sean X.
- PLoS ONE, Vol. 8, Issue 1
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
journal, January 2013
- Lacerda, Miguel; Moore, Penny L.; Ngandu, Nobubelo K.
- Virology Journal, Vol. 10, Issue 1
Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques
journal, May 2018
- Jia, Manxue; Lu, Hong; Kong, Xiang-Peng
- Viruses, Vol. 10, Issue 5
Ancestral sequences from an elite neutralizer proximal to the development of neutralization resistance as a potential source of HIV vaccine immunogens
journal, April 2019
- Mesa, Kathryn A.; Yu, Bin; Wrin, Terri
- PLOS ONE, Vol. 14, Issue 4
HIV-1 transmission and viral adaptation to the host
journal, January 2012
- Gijsbers, Esther F.; Schuitemaker, Hanneke; Kootstra, Neeltje A.
- Future Virology, Vol. 7, Issue 1
Correction for Anthony et al., “Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope”
journal, May 2018
- Anthony, Colin; York, Talita; Bekker, Valerie
- Journal of Virology, Vol. 92, Issue 9
Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
journal, December 2018
- Mabvakure, Batsirai M.; Scheepers, Cathrine; Garrett, Nigel
- Journal of Virology, Vol. 93, Issue 6
Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification
journal, January 2016
- Li, Hui; Stoddard, Mark B.; Wang, Shuyi
- Journal of Virology, Vol. 90, Issue 1
Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants
journal, April 2020
- Martinez, David R.; Tu, Joshua J.; Kumar, Amit
- mBio, Vol. 11, Issue 2
HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
journal, January 2011
- Cicala, Claudia; Arthos, James; Fauci, Anthony S.
- Journal of Translational Medicine, Vol. 9, Issue S1
HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection
journal, September 2012
- Basu, Debby; Kraft, Colleen S.; Murphy, Megan K.
- Retrovirology, Vol. 9, Issue 1
Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes
journal, June 2015
- Peters, Paul J.; Gonzalez-Perez, Maria Paz; Musich, Thomas
- Retrovirology, Vol. 12, Issue 1
HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds
journal, July 2016
- van den Kerkhof, Tom L. G. M.; de Taeye, Steven W.; Boeser-Nunnink, Brigitte D.
- Retrovirology, Vol. 13, Issue 1
HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth
journal, November 2018
- van Schooten, Jelle; van Gils, Marit J.
- Retrovirology, Vol. 15, Issue 1
Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein
journal, October 2016
- Tian, Jianhui; López, Cesar A.; Derdeyn, Cynthia A.
- PLOS Computational Biology, Vol. 12, Issue 10
Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies
journal, August 2018
- Otsuka, Yuka; Schmitt, Kimberly; Quinlan, Brian D.
- PLOS Pathogens, Vol. 14, Issue 8
VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120
journal, January 2019
- Smith, S. Abigail; Burton, Samantha L.; Kilembe, William
- Frontiers in Immunology, Vol. 9
Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
journal, May 2019
- Hutchinson, Jennie M.; Mesa, Kathryn A.; Alexander, David L.
- Frontiers in Immunology, Vol. 10
The Janus Face of Follicular T Helper Cells in Chronic Viral Infections
text, January 2018
- Ute, Greczmiel,; Annette, Oxenius,
- ETH Zurich
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
text, January 2013
- Lacerda, Miguel; Moore, Penny; Ngandu, Nobubelo
- Columbia University