Biomechanical Feedback Strengthens Jammed Cellular Packings
Abstract
Growth in confined spaces can drive cellular populations through a jamming transition from a fluidlike state to a solidlike state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures (over 1 MPa), which in turn feed back onto cellular physiology by slowing or even stalling cell growth. Using numerical simulations, we investigate how this feedback impacts the mechanical properties of model jammed cell populations. In this work, we find that feedback directs growth toward poorly coordinated regions, resulting in an excess number of cell-cell contacts that rigidify cell packings. Cell packings possess anomalously large shear and bulk moduli that depend sensitively on the strength of feedback. These results demonstrate that mechanical feedback on the single-cell level is a simple mechanism by which living systems may tune their population-level mechanical properties.
- Authors:
-
- Univ. of California, Berkeley, CA (United States). Dept. of Physics and Integrative Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)
- Sponsoring Org.:
- USDOE Office of Science (SC); Simons Foundation; National Science Foundation (NSF); National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH)
- OSTI Identifier:
- 1527126
- Alternate Identifier(s):
- OSTI ID: 1515111
- Grant/Contract Number:
- AC02-05CH11231; 327934; 1555330; R01GM115851
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Physical Review Letters
- Additional Journal Information:
- Journal Volume: 122; Journal Issue: 20; Journal ID: ISSN 0031-9007
- Publisher:
- American Physical Society (APS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Citation Formats
Gniewek, Pawel, Schreck, Carl F., and Hallatschek, Oskar. Biomechanical Feedback Strengthens Jammed Cellular Packings. United States: N. p., 2019.
Web. doi:10.1103/PhysRevLett.122.208102.
Gniewek, Pawel, Schreck, Carl F., & Hallatschek, Oskar. Biomechanical Feedback Strengthens Jammed Cellular Packings. United States. https://doi.org/10.1103/PhysRevLett.122.208102
Gniewek, Pawel, Schreck, Carl F., and Hallatschek, Oskar. Wed .
"Biomechanical Feedback Strengthens Jammed Cellular Packings". United States. https://doi.org/10.1103/PhysRevLett.122.208102. https://www.osti.gov/servlets/purl/1527126.
@article{osti_1527126,
title = {Biomechanical Feedback Strengthens Jammed Cellular Packings},
author = {Gniewek, Pawel and Schreck, Carl F. and Hallatschek, Oskar},
abstractNote = {Growth in confined spaces can drive cellular populations through a jamming transition from a fluidlike state to a solidlike state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures (over 1 MPa), which in turn feed back onto cellular physiology by slowing or even stalling cell growth. Using numerical simulations, we investigate how this feedback impacts the mechanical properties of model jammed cell populations. In this work, we find that feedback directs growth toward poorly coordinated regions, resulting in an excess number of cell-cell contacts that rigidify cell packings. Cell packings possess anomalously large shear and bulk moduli that depend sensitively on the strength of feedback. These results demonstrate that mechanical feedback on the single-cell level is a simple mechanism by which living systems may tune their population-level mechanical properties.},
doi = {10.1103/PhysRevLett.122.208102},
journal = {Physical Review Letters},
number = 20,
volume = 122,
place = {United States},
year = {Wed May 22 00:00:00 EDT 2019},
month = {Wed May 22 00:00:00 EDT 2019}
}
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