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Title: Large Scale Accelerator Production of 225Ac: Effective Cross sections for 78-192 MeV Protons Incident on 232Th Targets

Actinium-225 and 213Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of 225Ac. The high energy proton spallation reaction on natural thorium metal target has been utilized to produce millicurie quantities of 225Ac. The results of sixteen irradiation experiments of Th metal at beam energies between 78 and 200 MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes as well as for some of the fission products are presented. The cross sections for production of 225Ac range from 3.6 to 16.7 mb in the incident proton energy range of 78 to 192 MeV. Based on these data, production of Curie quantities of 225Ac is possible by irradiating a 5.0 g cm-2232Th target for 10 days in either BNL or LANL proton irradiation facilities.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [2] ;  [3] ;  [3] ;  [3] ;  [4] ;  [4] ;  [4] ;  [3] ;  [3] ;  [3] ;  [5] ;  [6] ;  [2] ;  [4]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Nuclear Engineering
  2. Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division
  5. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States).Physics Division
  6. Univ. of Tennessee, Knoxville, TN (United States). Dept. of Nuclear Engineering
Publication Date:
OSTI Identifier:
1333066
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 118; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Research Org:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE Actinium; Alpha-emitting; Radiotherapy; Proton irradiation; Thorium; 225Ac; 226Ac; 227Ac; 227Th; 228Th; 99Mo; 140Ba; 139Ce; 141Ce; 143Ce; 144Ce