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Title: Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma

Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. In addition, advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [2] ;  [3] ;  [3] ;  [2] ;  [2] ;  [2] ;  [2] ;  [2] ;  [2] ;  [4] ;  [4] ;  [4] ;  [4] ;  [4] ;  [5] ;  [6] more »;  [7] ;  [8] ;  [9] ;  [9] ;  [10] ;  [11] ;  [12] ;  [9] ;  [13] ;  [2] ;  [2] ;  [14] ;  [2] ;  [15] ;  [10] ;  [16] ;  [17] ;  [2] ;  [18] ;  [1] « less
  1. Ontario Institute for Cancer Research, Toronto, ON (Canada); Mount Sinai Hospital, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada)
  2. Ontario Institute for Cancer Research, Toronto, ON (Canada)
  3. Mount Sinai Hospital, Toronto, ON (Canada)
  4. The Univ. of Liverpool, Liverpool (United Kingdom)
  5. Heidelberg University Hospital, Heidelberg (Germany)
  6. Mayo Clinic, Rochester, MN (United States)
  7. Massachusetts General Hospital, Boston, MA (United States)
  8. Univ. of Nebraska Medical Centre, Omaha, NE (United States)
  9. Mount Sinai Hospital, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
  10. Princess Margaret Cancer Centre, Toronto, ON (Canada)
  11. Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
  12. Univ. Health Network, Toronto, ON (Canada)
  13. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
  14. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. Health Network, Toronto, ON (Canada)
  15. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  16. Univ. of Toronto, Toronto, ON (Canada)
  17. Genome Technologies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada17Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
  18. Ontario Institute for Cancer Research, Toronto, ON (Canada); Univ. of Toronto, Toronto, ON (Canada)
Publication Date:
OSTI Identifier:
1331271
Report Number(s):
LA-UR--16-20982
Journal ID: ISSN 2374-2437
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
JAMA Oncology
Additional Journal Information:
Journal Name: JAMA Oncology; Journal ID: ISSN 2374-2437
Publisher:
American Medical Association
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
LDRD; USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES biological science