Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study
Abstract
Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. As a result, our new findings may provide new design principles for safer, improved drug delivery platforms.
- Authors:
-
- Wayne State Univ., Detroit, MI (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Shanghai Jiao Tong Univ., Shanghai (China)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1329113
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry
- Additional Journal Information:
- Journal Volume: 120; Journal Issue: 38; Journal ID: ISSN 1520-6106
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Dhindsa, Gurpreet K., Bhowmik, Debsindhu, Goswami, Monojoy, O’Neill, Hugh, Mamontov, Eugene, Sumpter, Bobby G., Hong, Liang, Ganesh, Panchapakesan, and Chu, Xiang -qiang. Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study. United States: N. p., 2016.
Web. doi:10.1021/acs.jpcb.6b07511.
Dhindsa, Gurpreet K., Bhowmik, Debsindhu, Goswami, Monojoy, O’Neill, Hugh, Mamontov, Eugene, Sumpter, Bobby G., Hong, Liang, Ganesh, Panchapakesan, & Chu, Xiang -qiang. Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study. United States. https://doi.org/10.1021/acs.jpcb.6b07511
Dhindsa, Gurpreet K., Bhowmik, Debsindhu, Goswami, Monojoy, O’Neill, Hugh, Mamontov, Eugene, Sumpter, Bobby G., Hong, Liang, Ganesh, Panchapakesan, and Chu, Xiang -qiang. Thu .
"Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study". United States. https://doi.org/10.1021/acs.jpcb.6b07511. https://www.osti.gov/servlets/purl/1329113.
@article{osti_1329113,
title = {Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study},
author = {Dhindsa, Gurpreet K. and Bhowmik, Debsindhu and Goswami, Monojoy and O’Neill, Hugh and Mamontov, Eugene and Sumpter, Bobby G. and Hong, Liang and Ganesh, Panchapakesan and Chu, Xiang -qiang},
abstractNote = {Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. As a result, our new findings may provide new design principles for safer, improved drug delivery platforms.},
doi = {10.1021/acs.jpcb.6b07511},
journal = {Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry},
number = 38,
volume = 120,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2016},
month = {Thu Sep 01 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
The emerging field of RNA nanotechnology
journal, November 2010
- Guo, Peixuan
- Nature Nanotechnology, Vol. 5, Issue 12
Inorganic Nanoparticles as Protein Mimics
journal, October 2010
- Kotov, Nicholas A.
- Science, Vol. 330, Issue 6001
Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy
journal, July 2010
- Liu, Kuang-Kai; Zheng, Wen-Wei; Wang, Chi-Ching
- Nanotechnology, Vol. 21, Issue 31
Cancer Nanomedicine: From Drug Delivery to Imaging
journal, December 2013
- Chow, E. K. -H.; Ho, D.
- Science Translational Medicine, Vol. 5, Issue 216
Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform
journal, August 2013
- Mochalin, Vadym N.; Pentecost, Amanda; Li, Xue-Mei
- Molecular Pharmaceutics, Vol. 10, Issue 10
The properties and applications of nanodiamonds
journal, December 2011
- Mochalin, Vadym N.; Shenderova, Olga; Ho, Dean
- Nature Nanotechnology, Vol. 7, Issue 1
Contribution of Functional Groups to the Raman Spectrum of Nanodiamond Powders
journal, January 2009
- Mochalin, Vadym; Osswald, Sebastian; Gogotsi, Yury
- Chemistry of Materials, Vol. 21, Issue 2
Therapeutic applications of low-toxicity spherical nanocarbon materials
journal, February 2014
- Wang, Jing; Hu, Zhongbo; Xu, Jianxun
- NPG Asia Materials, Vol. 6, Issue 2
Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering
journal, July 2012
- Zhang, Qingwei; Mochalin, Vadym N.; Neitzel, Ioannis
- Biomaterials, Vol. 33, Issue 20
Fluorescent PLLA-nanodiamond composites for bone tissue engineering
journal, January 2011
- Zhang, Qingwei; Mochalin, Vadym N.; Neitzel, Ioannis
- Biomaterials, Vol. 32, Issue 1
Nanodiamond–polymer composites
journal, September 2015
- Mochalin, Vadym N.; Gogotsi, Yury
- Diamond and Related Materials, Vol. 58
Wet Chemistry Route to Hydrophobic Blue Fluorescent Nanodiamond
journal, April 2009
- Mochalin, Vadym N.; Gogotsi, Yury
- Journal of the American Chemical Society, Vol. 131, Issue 13
Spectroscopic study of bio-functionalized nanodiamonds
journal, April 2006
- Chung, P. -H.; Perevedentseva, E.; Tu, J. -S.
- Diamond and Related Materials, Vol. 15, Issue 4-8
Solid-phase synthesis, characterization, and cellular activities of collagen-model Nanodiamond-peptide conjugates: Collagen-Model Nanodiamond-Peptide Conjugates
journal, May 2015
- Knapinska, Anna M.; Tokmina-Roszyk, Dorota; Amar, Sabrina
- Biopolymers, Vol. 104, Issue 3
Biomolecular coronas provide the biological identity of nanosized materials
journal, December 2012
- Monopoli, Marco P.; Åberg, Christoffer; Salvati, Anna
- Nature Nanotechnology, Vol. 7, Issue 12
Small Angle Neutron and X-Ray Scattering Reveal Conformational Differences in Detergents Affecting Rhodopsin Activation
journal, January 2015
- Shrestha, Utsab; Bhowmik, Debsindhu; Perera, Suchithranga M. D. C.
- Biophysical Journal, Vol. 108, Issue 2
Aqueous solutions of ionenes: interactions and counterion specific effects as seen by neutron scattering
journal, January 2012
- Malikova, Natalie; Čebašek, Sašo; Glenisson, Vincent
- Physical Chemistry Chemical Physics, Vol. 14, Issue 37
Probing the Domain Motions of an Oligomeric Protein from Deep-Sea Hyperthermophile by Neutron Spin Echo
journal, January 2015
- Bhowmik, Debsindhu; Kaur Dhindsa, Gurpreet; Rusek, Andrew J.
- Biophysical Journal, Vol. 108, Issue 2
Effects of pressure on the dynamics of an oligomeric protein from deep-sea hyperthermophile
journal, October 2015
- Shrestha, Utsab R.; Bhowmik, Debsindhu; Copley, John R. D.
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 45
Single Chain Dynamic Structure Factor of Linear Polymers in an All-Polymer Nano-Composite
journal, March 2016
- Arbe, Arantxa; Pomposo, José A.; Asenjo-Sanz, Isabel
- Macromolecules, Vol. 49, Issue 6
Temperature Dependence of Logarithmic-like Relaxational Dynamics of Hydrated tRNA
journal, March 2013
- Chu, Xiang-qiang; Mamontov, Eugene; O’Neill, Hugh
- The Journal of Physical Chemistry Letters, Vol. 4, Issue 6
Dynamic heterogeneity controls diffusion and viscosity near biological interfaces
journal, January 2014
- Pronk, Sander; Lindahl, Erik; Kasson, Peter M.
- Nature Communications, Vol. 5, Issue 1
Adsorption of proteins in channels of carbon nanotubes: Effect of surface chemistry
journal, March 2013
- Kharlamova, Marianna V.; Mochalin, Vadym N.; Lukatskaya, Maria R.
- Materials Express, Vol. 3, Issue 1
A time-of-flight backscattering spectrometer at the Spallation Neutron Source, BASIS
journal, August 2011
- Mamontov, E.; Herwig, K. W.
- Review of Scientific Instruments, Vol. 82, Issue 8
DAVE: A Comprehensive Software Suite for the Reduction, Visualization, and Analysis of Low Energy Neutron Spectroscopic Data
journal, November 2009
- Azuah, Richard Tumanjong; Kneller, Larry R.; Qiu, Yiming
- Journal of Research of the National Institute of Standards and Technology, Vol. 114, Issue 6
How Soft Is a Protein? A Protein Dynamics Force Constant Measured by Neutron Scattering
journal, June 2000
- Zaccai, G.
- Science, Vol. 288, Issue 5471
Evidence of a Higher-Order Singularity in Dense Short-Ranged Attractive Colloids
journal, December 2003
- Sciortino, Francesco; Tartaglia, Piero; Zaccarelli, Emanuela
- Physical Review Letters, Vol. 91, Issue 26
Experimental evidence of logarithmic relaxation in single-particle dynamics of hydrated protein molecules
journal, January 2010
- Chu, Xiang-qiang; Lagi, Marco; Mamontov, Eugene
- Soft Matter, Vol. 6, Issue 12
Logarithmic Decay in Single-Particle Relaxation of Hydrated Lysozyme Powder
journal, September 2009
- Lagi, Marco; Baglioni, Piero; Chen, Sow-Hsin
- Physical Review Letters, Vol. 103, Issue 10
Logarithmic relaxation in glass-forming systems
journal, July 2002
- Götze, W.; Sperl, M.
- Physical Review E, Vol. 66, Issue 1
Is there a higher-order mode coupling transition in polymer blends?
journal, May 2006
- Moreno, Angel J.; Colmenero, Juan
- The Journal of Chemical Physics, Vol. 124, Issue 18
Power-law and logarithmic relaxations of hydrated proteins: A molecular dynamics simulations study
journal, November 2012
- Kämpf, K.; Klameth, F.; Vogel, M.
- The Journal of Chemical Physics, Vol. 137, Issue 20
Anomalous Diffusion and Relaxation Close to Thermal Equilibrium: A Fractional Fokker-Planck Equation Approach
journal, May 1999
- Metzler, Ralf; Barkai, Eli; Klafter, Joseph
- Physical Review Letters, Vol. 82, Issue 18
Fractional Brownian dynamics in proteins
journal, November 2004
- Kneller, G. R.; Hinsen, K.
- The Journal of Chemical Physics, Vol. 121, Issue 20
Crystalline ribonuclease A loses function below the dynamical transition at 220 K
journal, June 1992
- Rasmussen, Bjarne F.; Stock, Ann M.; Ringe, Dagmar
- Nature, Vol. 357, Issue 6377
Formation of Glasses from Liquids and Biopolymers
journal, March 1995
- Angell, C. A.
- Science, Vol. 267, Issue 5206
A unified model of protein dynamics
journal, February 2009
- Frauenfelder, H.; Chen, G.; Berendzen, J.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 13
Supercooled liquids and the glass transition
journal, March 2001
- Debenedetti, Pablo G.; Stillinger, Frank H.
- Nature, Vol. 410, Issue 6825
Molecular View of Water Dynamics near Model Peptides
journal, July 2005
- Russo, Daniela; Murarka, Rajesh K.; Copley, John R. D.
- The Journal of Physical Chemistry B, Vol. 109, Issue 26
Relaxation processes in liquids: Variations on a theme by Stokes and Einstein
journal, March 2013
- Shi, Zane; Debenedetti, Pablo G.; Stillinger, Frank H.
- The Journal of Chemical Physics, Vol. 138, Issue 12
Scalable molecular dynamics with NAMD
journal, January 2005
- Phillips, James C.; Braun, Rosemary; Wang, Wei
- Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802
n Moldyn: A program package for a neutron scattering oriented analysis of molecular dynamics simulations
journal, March 2003
- Róg, T.; Murzyn, K.; Hinsen, K.
- Journal of Computational Chemistry, Vol. 24, Issue 5
Aqueous solutions of tetraalkylammonium halides: ion hydration, dynamics and ion–ion interactions in light of steric effects
journal, January 2014
- Bhowmik, Debsindhu; Malikova, Natalie; Mériguet, Guillaume
- Phys. Chem. Chem. Phys., Vol. 16, Issue 26
All-atom empirical force field for nucleic acids: II. Application to molecular dynamics simulations of DNA and RNA in solution
journal, January 2000
- MacKerell, Alexander D.; Banavali, Nilesh K.
- Journal of Computational Chemistry, Vol. 21, Issue 2
Comparison of simple potential functions for simulating liquid water
journal, July 1983
- Jorgensen, William L.; Chandrasekhar, Jayaraman; Madura, Jeffry D.
- The Journal of Chemical Physics, Vol. 79, Issue 2
Interfacial Water at Hydrophobic and Hydrophilic Surfaces: Slip, Viscosity, and Diffusion
journal, September 2009
- Sendner, Christian; Horinek, Dominik; Bocquet, Lyderic
- Langmuir, Vol. 25, Issue 18
VMD: Visual molecular dynamics
journal, February 1996
- Humphrey, William; Dalke, Andrew; Schulten, Klaus
- Journal of Molecular Graphics, Vol. 14, Issue 1
Observation of a dynamic crossover in RNA hydration water which triggers a dynamic transition in the biopolymer
journal, January 2008
- Chu, Xiang-qiang; Fratini, Emiliano; Baglioni, Piero
- Physical Review E, Vol. 77, Issue 1
Influence of Hydration on the Dynamics of Lysozyme
journal, October 2006
- Roh, J. H.; Curtis, J. E.; Azzam, S.
- Biophysical Journal, Vol. 91, Issue 7
Onsets of Anharmonicity in Protein Dynamics
journal, July 2005
- Roh, J. H.; Novikov, V. N.; Gregory, R. B.
- Physical Review Letters, Vol. 95, Issue 3
Dynamic Transition in tRNA is Solvent Induced
journal, January 2006
- Caliskan, Gokhan; Briber, Robert M.; Thirumalai, D.
- Journal of the American Chemical Society, Vol. 128, Issue 1
Temperature-Dependent Dynamics of Dry and Hydrated β-Casein Studied by Quasielastic Neutron Scattering
journal, September 2014
- Dhindsa, Gurpreet K.; Tyagi, Madhusudan; Chu, Xiang-qiang
- The Journal of Physical Chemistry B, Vol. 118, Issue 37
Rhodopsin Photoactivation Dynamics Revealed by Quasi-Elastic Neutron Scattering
journal, January 2015
- Bhowmik, Debsindhu; Shrestha, Utsab; Perera, Suchithranga M. d. c.
- Biophysical Journal, Vol. 108, Issue 2
Apparent Decoupling of the Dynamics of a Protein from the Dynamics of its Aqueous Solvent
journal, January 2012
- Chu, Xiang-qiang; Mamontov, Eugene; O’Neill, Hugh
- The Journal of Physical Chemistry Letters, Vol. 3, Issue 3
Relaxation in liquids, polymers and plastic crystals — strong/fragile patterns and problems
journal, June 1991
- Angell, C. A.
- Journal of Non-Crystalline Solids, Vol. 131-133
Observation of fragile-to-strong dynamic crossover in protein hydration water
journal, June 2006
- Chen, S. -H.; Liu, L.; Fratini, E.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 24
The violation of the Stokes-Einstein relation in supercooled water
journal, August 2006
- Chen, S. -H.; Mallamace, F.; Mou, C. -Y.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 35
Correlation between non-Debye behavior and Q behavior of the α relaxation in glass-forming polymeric systems
journal, July 1992
- Colmenero, J.; Alegría, A.; Arbe, A.
- Physical Review Letters, Vol. 69, Issue 3
Crossover from Debye to non-Debye dynamical behavior of the α relaxation observed by quasielastic neutron scattering in a glass-forming polymer
journal, October 1993
- Colmenero, J.; Arbe, A.; Alegría, A.
- Physical Review Letters, Vol. 71, Issue 16
Investigation of a Nanocomposite of 75 wt % Poly(methyl methacrylate) Nanoparticles with 25 wt % Poly(ethylene oxide) Linear Chains: A Quasielatic Neutron Scattering, Calorimetric, and WAXS Study
journal, April 2014
- Bhowmik, D.; Pomposo, J. A.; Juranyi, F.
- Macromolecules, Vol. 47, Issue 9
Microscopic Dynamics in Nanocomposites of Poly(ethylene oxide) and Poly(methyl methacrylate) Soft Nanoparticles: A Quasi-Elastic Neutron Scattering Study
journal, December 2013
- Bhowmik, D.; Pomposo, J. A.; Juranyi, F.
- Macromolecules, Vol. 47, Issue 1
Crossover from Independent to Cooperative Segmental Dynamics in Polymers: Experimental Realization in Poly(Vinyl Chloride)
journal, March 1997
- Colmenero, J.; Arbe, A.; Coddens, G.
- Physical Review Letters, Vol. 78, Issue 10
Interpretation of anomalous momentum transfer dependences of local chain motion of polymers observed by quasielastic incoherent neutron scattering experiments
journal, November 1992
- Ngai, K. L.; Colmenero, J.; Alegria, A.
- Macromolecules, Vol. 25, Issue 24
Study of tetrabutylammonium bromide in aqueous solution by neutron scattering
journal, November 2012
- Bhowmik, D.; Malikova, N.; Teixeira, J.
- The European Physical Journal Special Topics, Vol. 213, Issue 1
Myoglobin on Silica: A Case Study of the Impact of Adsorption on Protein Structure and Dynamics
journal, October 2013
- Devineau, Stéphanie; Zanotti, Jean-Marc; Loupiac, Camille
- Langmuir, Vol. 29, Issue 44
Role of Water and Ions on the Dynamical Transition of RNA
journal, September 2013
- Zhang, Hailiang; Khodadadi, Sheila; Fiedler, Steven L.
- The Journal of Physical Chemistry Letters, Vol. 4, Issue 19
Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen
journal, January 1905
- Einstein, A.
- Annalen der Physik, Vol. 322, Issue 8
Dynamic heterogeneity comes to life
journal, March 2011
- Garrahan, J. P.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 12
Glass-like dynamics of collective cell migration
journal, February 2011
- Angelini, T. E.; Hannezo, E.; Trepat, X.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 12
Resolving the Mystery of the Chain Friction Mechanism in Polymer Liquids
journal, June 2009
- Sokolov, Alexei P.; Schweizer, Kenneth S.
- Physical Review Letters, Vol. 102, Issue 24
Theoretical perspective on the glass transition and amorphous materials
journal, June 2011
- Berthier, Ludovic; Biroli, Giulio
- Reviews of Modern Physics, Vol. 83, Issue 2
S PATIALLY H ETEROGENEOUS D YNAMICS IN S UPERCOOLED L IQUIDS
journal, October 2000
- Ediger, M. D.
- Annual Review of Physical Chemistry, Vol. 51, Issue 1
Dynamics of tRNA at Different Levels of Hydration
journal, April 2009
- Roh, J. H.; Briber, R. M.; Damjanovic, A.
- Biophysical Journal, Vol. 96, Issue 7
Works referencing / citing this record:
Nanodiamonds and Their Applications in Cells
journal, March 2018
- Chipaux, Mayeul; van der Laan, Kiran J.; Hemelaar, Simon R.
- Small, Vol. 14, Issue 24
Neutron scattering in the biological sciences: progress and prospects
journal, December 2018
- Ashkar, Rana; Bilheux, Hassina Z.; Bordallo, Heliosa
- Acta Crystallographica Section D Structural Biology, Vol. 74, Issue 12
Impact of hydration and temperature history on the structure and dynamics of lignin
journal, January 2018
- Vural, Derya; Gainaru, Catalin; O'Neill, Hugh
- Green Chemistry, Vol. 20, Issue 7
Deep clustering of protein folding simulations
journal, December 2018
- Bhowmik, Debsindhu; Gao, Shang; Young, Michael T.
- BMC Bioinformatics, Vol. 19, Issue S18
Deep diving into the comparative study of Choline dynamics using molecular dynamics simulation and neutron scattering technique
preprint, January 2018
- Bhowmik, Debsindhu
- arXiv
A comparative study of solvent dynamics in Choline Bromide aqueous solution using combination of neutron scattering technique and molecular dynamics simulation
preprint, January 2018
- Bhowmik, Debsindhu
- arXiv