skip to main content

DOE PAGESDOE PAGES

Title: High-energy proton imaging for biomedical applications

The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. As a result, tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [1] ;  [2] ;  [4] ;  [5] ;  [1] ;  [6] ;  [6] ;  [6] ;  [6] ;  [6] ;  [1]
  1. GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany)
  2. GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Technische Univ. Darmstadt, Darmstadt (Germany)
  3. Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Cologne (Germany)
  4. Brookhaven National Lab. (BNL), Upton, NY (United States)
  5. GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Technische Univ. Darmstadt, Darmstadt (Germany); Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main (Germany)
  6. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
OSTI Identifier:
1321780
Report Number(s):
LA-UR--16-23081
Journal ID: ISSN 2045-2322
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 6; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE