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Title: HIV-1 Transmission during Early Infection in Men Who Have Sex with Men: A Phylodynamic Analysis

Conventional epidemiological surveillance of infectious diseases is focused on characterization of incident infections and estimation of the number of prevalent infections. Advances in methods for the analysis of the population-level genetic variation of viruses can potentially provide information about donors, not just recipients, of infection. Genetic sequences from many viruses are increasingly abundant, especially HIV, which is routinely sequenced for surveillance of drug resistance mutations. In this study, we conducted a phylodynamic analysis of HIV genetic sequence data and surveillance data from a US population of men who have sex with men (MSM) and estimated incidence and transmission rates by stage of infection.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [4] ;  [2]
  1. Imperial College, London (United Kingdom)
  2. Univ. of Michigan, Ann Arbor, MI (United States)
  3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Michigan Department of Community Health, Detroit, MI (United States)
Publication Date:
OSTI Identifier:
1321730
Report Number(s):
LA-UR--13-23215
Journal ID: ISSN 1549-1676
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
PLoS Medicine
Additional Journal Information:
Journal Volume: 10; Journal Issue: 12; Journal ID: ISSN 1549-1676
Publisher:
Public Library of Science
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES