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Title: Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames

Three-dimensional mesoscale clusters that are formed from nanoparticles spatially arranged in pre-determined positions can be thought of as mesoscale analogues of molecules. These nanoparticle architectures could offer tailored properties due to collective effects, but developing a general platform for fabricating such clusters is a significant challenge. Here, we report a strategy for assembling 3D nanoparticle clusters that uses a molecular frame designed with encoded vertices for particle placement. The frame is a DNA origami octahedron and can be used to fabricate clusters with various symmetries and particle compositions. Cryo-electron microscopy is used to uncover the structure of the DNA frame and to reveal that the nanoparticles are spatially coordinated in the prescribed manner. We show that the DNA frame and one set of nanoparticles can be used to create nanoclusters with different chiroptical activities. We also show that the octahedra can serve as programmable interparticle linkers, allowing one- and two-dimensional arrays to be assembled that have designed particle arrangements.
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [4] ;  [5] ;  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States). Center for Functional Nanomaterials (CFN)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States). Biosciences Dept.
  3. Brookhaven National Lab. (BNL), Upton, NY (United States). Biosciences Dept.; Stony Brook Univ., NY (United States). Dept. of Biochemistry and Cell Biology
  4. Harvard Medical School, Boston, MA (United States). Dept. of Biological Chemistry and Molecular Pharmacology; Dana-Farber Cancer Inst., Boston, MA (United States). Dept. of Cancer Biology; Harvard Univ., Cambridge, MA (United States). Wyss Inst. for Biologically Inspired Engineering
  5. Harvard Medical School, Boston, MA (United States). Dept. of Biological Chemistry and Molecular Pharmacology; Dana-Farber Cancer Inst., Boston, MA (United States). Dept. of Cancer Biology; Harvard Univ., Cambridge, MA (United States). Wyss Inst. for Biologically Inspired Engineering
Publication Date:
OSTI Identifier:
1302991
Report Number(s):
BNL--108384-2015-JA
Journal ID: ISSN 1748-3387; KC0403020
Grant/Contract Number:
SC0012704; AG029979; 1317694; 1435964
Type:
Accepted Manuscript
Journal Name:
Nature Nanotechnology
Additional Journal Information:
Journal Volume: 10; Journal Issue: 7; Journal ID: ISSN 1748-3387
Publisher:
Nature Publishing Group
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); National Inst. of Health (NIH); National Science Foundation (NSF)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY DNA nanostructures