Optimal combinations of broadly neutralizing antibodies for prevention and treatments of HIV-1 clade C infection
Abstract
In this study, the identification of a new generation of potent broadly neutralizing HIV-1 antibodies (bnAbs) has generated substantial interest in their potential use for the prevention and/or treatment of HIV-1 infection. While combinations of bnAbs targeting distinct epitopes on the viral envelope (Env) will likely be required to overcome the extraordinary diversity of HIV-1, a key outstanding question is which bnAbs, and how many, will be needed to achieve optimal clinical benefit. We assessed the neutralizing activity of 15 bnAbs targeting four distinct epitopes of Env, including the CD4-binding site (CD4bs), the V1/V2-glycan region, the V3-glycan region, and the gp41 membrane proximal external region (MPER), against a panel of 200 acute/early clade C HIV-1 Env pseudoviruses. A mathematical model was developed that predicted neutralization by a subset of experimentally evaluated bnAb combinations with high accuracy. Using this model, we performed a comprehensive and systematic comparison of the predicted neutralizing activity of over 1,600 possible double, triple, and quadruple bnAb combinations. The most promising bnAb combinations were identified based not only on breadth and potency of neutralization, but also other relevant measures, such as the extent of complete neutralization and instantaneous inhibitory potential (IIP). By this set of criteria, triplemore »
- Authors:
-
more »
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Santa Fe Institute, Santa Fe, NM (United States)
- Univ. of Cape Town and NHLS, Cape Town (South Africa)
- Beth Israel Deaconess Medical Center, Boston, MA (United States)
- Duke Univ. Medical Center, Durham, NC (United States)
- NIAID, NIH, Bethesda, MD (United States)
- Univ. of KwaZulu-Natal, Durban (South Africa)
- The Scripps Research Institute, La Jolla, CA (United States)
- The Rockefeller Univ., New York, NY (United States)
- Univ. of KwaZulu-Natal, Durban (South Africa); Univ. of the Witwatersrand, Johannesburg (South Africa)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1291229
- Report Number(s):
- LA-UR-16-20914
Journal ID: ISSN 1553-7374
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Pathogens
- Additional Journal Information:
- Journal Volume: 12; Journal Issue: 3; Journal ID: ISSN 1553-7374
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; biological science; HIV-1; antibodies; antiretrovirals; complement system; immunotherapy; blood plasma; microbial genetics; pharmacokinetics
Citation Formats
Wagh, Kshitij, Bhattacharya, Tanmoy, Williamson, Carolyn, Robles, Alex, Bayne, Madeleine, Garrity, Jetta, Rist, Michael, Rademeyer, Cecilia, Yoon, Hyejin, Lapedes, Alan Scott, Gao, Hongmei, Greene, Kelli, Louder, Mark K., Kong, Rui, Karim, Salim Abdool, Burton, Dennis R., Barouch, Dan H., Nussenzweig, Michael C., Mascola, John R., Morris, Lynn, Montefiori, David, Korber, Bette Tina, and Seamon, Michael S. Optimal combinations of broadly neutralizing antibodies for prevention and treatments of HIV-1 clade C infection. United States: N. p., 2016.
Web. doi:10.1371/journal.ppat.1005520.
Wagh, Kshitij, Bhattacharya, Tanmoy, Williamson, Carolyn, Robles, Alex, Bayne, Madeleine, Garrity, Jetta, Rist, Michael, Rademeyer, Cecilia, Yoon, Hyejin, Lapedes, Alan Scott, Gao, Hongmei, Greene, Kelli, Louder, Mark K., Kong, Rui, Karim, Salim Abdool, Burton, Dennis R., Barouch, Dan H., Nussenzweig, Michael C., Mascola, John R., Morris, Lynn, Montefiori, David, Korber, Bette Tina, & Seamon, Michael S. Optimal combinations of broadly neutralizing antibodies for prevention and treatments of HIV-1 clade C infection. United States. https://doi.org/10.1371/journal.ppat.1005520
Wagh, Kshitij, Bhattacharya, Tanmoy, Williamson, Carolyn, Robles, Alex, Bayne, Madeleine, Garrity, Jetta, Rist, Michael, Rademeyer, Cecilia, Yoon, Hyejin, Lapedes, Alan Scott, Gao, Hongmei, Greene, Kelli, Louder, Mark K., Kong, Rui, Karim, Salim Abdool, Burton, Dennis R., Barouch, Dan H., Nussenzweig, Michael C., Mascola, John R., Morris, Lynn, Montefiori, David, Korber, Bette Tina, and Seamon, Michael S. Wed .
"Optimal combinations of broadly neutralizing antibodies for prevention and treatments of HIV-1 clade C infection". United States. https://doi.org/10.1371/journal.ppat.1005520. https://www.osti.gov/servlets/purl/1291229.
@article{osti_1291229,
title = {Optimal combinations of broadly neutralizing antibodies for prevention and treatments of HIV-1 clade C infection},
author = {Wagh, Kshitij and Bhattacharya, Tanmoy and Williamson, Carolyn and Robles, Alex and Bayne, Madeleine and Garrity, Jetta and Rist, Michael and Rademeyer, Cecilia and Yoon, Hyejin and Lapedes, Alan Scott and Gao, Hongmei and Greene, Kelli and Louder, Mark K. and Kong, Rui and Karim, Salim Abdool and Burton, Dennis R. and Barouch, Dan H. and Nussenzweig, Michael C. and Mascola, John R. and Morris, Lynn and Montefiori, David and Korber, Bette Tina and Seamon, Michael S.},
abstractNote = {In this study, the identification of a new generation of potent broadly neutralizing HIV-1 antibodies (bnAbs) has generated substantial interest in their potential use for the prevention and/or treatment of HIV-1 infection. While combinations of bnAbs targeting distinct epitopes on the viral envelope (Env) will likely be required to overcome the extraordinary diversity of HIV-1, a key outstanding question is which bnAbs, and how many, will be needed to achieve optimal clinical benefit. We assessed the neutralizing activity of 15 bnAbs targeting four distinct epitopes of Env, including the CD4-binding site (CD4bs), the V1/V2-glycan region, the V3-glycan region, and the gp41 membrane proximal external region (MPER), against a panel of 200 acute/early clade C HIV-1 Env pseudoviruses. A mathematical model was developed that predicted neutralization by a subset of experimentally evaluated bnAb combinations with high accuracy. Using this model, we performed a comprehensive and systematic comparison of the predicted neutralizing activity of over 1,600 possible double, triple, and quadruple bnAb combinations. The most promising bnAb combinations were identified based not only on breadth and potency of neutralization, but also other relevant measures, such as the extent of complete neutralization and instantaneous inhibitory potential (IIP). By this set of criteria, triple and quadruple combinations of bnAbs were identified that were significantly more effective than the best double combinations, and further improved the probability of having multiple bnAbs simultaneously active against a given virus, a requirement that may be critical for countering escape in vivo. These results provide a rationale for advancing bnAb combinations with the best in vitro predictors of success into clinical trials for both the prevention and treatment of HIV-1 infection.},
doi = {10.1371/journal.ppat.1005520},
journal = {PLoS Pathogens},
number = 3,
volume = 12,
place = {United States},
year = {Wed Mar 30 00:00:00 EDT 2016},
month = {Wed Mar 30 00:00:00 EDT 2016}
}
Web of Science
Works referenced in this record:
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
journal, October 2012
- Moldt, B.; Rakasz, E. G.; Schultz, N.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 46
Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope
journal, September 2004
- Ofek, G.; Tang, M.; Sambor, A.
- Journal of Virology, Vol. 78, Issue 19
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
journal, August 2013
- Kwong, Peter D.; Mascola, John R.; Nabel, Gary J.
- Nature Reviews Immunology, Vol. 13, Issue 9
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
journal, November 2011
- McLellan, Jason S.; Pancera, Marie; Carrico, Chris
- Nature, Vol. 480, Issue 7377
Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro
journal, September 2001
- Parren, P. W. H. I.; Marx, P. A.; Hessell, A. J.
- Journal of Virology, Vol. 75, Issue 17
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
journal, September 2014
- Huang, Jinghe; Kang, Byong H.; Pancera, Marie
- Nature, Vol. 515, Issue 7525
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
journal, May 2013
- Julien, Jean-Philippe; Sok, Devin; Khayat, Reza
- PLoS Pathogens, Vol. 9, Issue 5
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
journal, April 2015
- Caskey, Marina; Klein, Florian; Lorenzi, Julio C. C.
- Nature, Vol. 522, Issue 7557
Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors
journal, January 2012
- Ketas, Thomas J.; Holuigue, Sophie; Matthews, Katie
- Virology, Vol. 422, Issue 1
Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
journal, May 2014
- Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten
- Immunity, Vol. 40, Issue 5
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
journal, November 2001
- Zwick, M. B.; Labrijn, A. F.; Wang, M.
- Journal of Virology, Vol. 75, Issue 22
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
journal, September 2013
- Horwitz, J. A.; Halper-Stromberg, A.; Mouquet, H.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 41
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
journal, July 2012
- Klein, Florian; Gaebler, Christian; Mouquet, Hugo
- The Journal of Experimental Medicine, Vol. 209, Issue 8
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
journal, June 2009
- Hessell, Ann J.; Poignard, Pascal; Hunter, Meredith
- Nature Medicine, Vol. 15, Issue 8
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
journal, May 2014
- Falkowska, Emilia; Le, Khoa M.; Ramos, Alejandra
- Immunity, Vol. 40, Issue 5
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
journal, November 1994
- Burton, D.; Pyati, J.; Koduri, R.
- Science, Vol. 266, Issue 5187
A Blueprint for HIV Vaccine Discovery
journal, October 2012
- Burton, Dennis R.; Ahmed, Rafi; Barouch, Dan H.
- Cell Host & Microbe, Vol. 12, Issue 4
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
journal, August 2014
- Ko, Sung-Youl; Pegu, Amarendra; Rudicell, Rebecca S.
- Nature, Vol. 514, Issue 7524
Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
journal, May 2014
- Sok, D.; Doores, K. J.; Briney, B.
- Science Translational Medicine, Vol. 6, Issue 236
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
journal, July 2014
- Pegu, A.; Yang, Z. -y.; Boyington, J. C.
- Science Translational Medicine, Vol. 6, Issue 243
Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization
journal, July 2014
- Kim, Arthur S.; Leaman, Daniel P.; Zwick, Michael B.
- PLoS Pathogens, Vol. 10, Issue 7
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
journal, February 2013
- Julien, Jean-Philippe; Lee, Jeong Hyun; Cupo, Albert
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 11
Strategies to guide the antibody affinity maturation process
journal, April 2015
- Doria-Rose, Nicole A.; Joyce, M. Gordon
- Current Opinion in Virology, Vol. 11
Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice
journal, August 2014
- Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian
- Cell, Vol. 158, Issue 5
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
journal, June 2008
- Shen, Lin; Peterson, Susan; Sedaghat, Ahmad R.
- Nature Medicine, Vol. 14, Issue 7
Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies
journal, September 2015
- Webb, Nicholas E.; Montefiori, David C.; Lee, Benhur
- Nature Communications, Vol. 6, Issue 1
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1
journal, July 2014
- Sarzotti-Kelsoe, Marcella; Bailer, Robert T.; Turk, Ellen
- Journal of Immunological Methods, Vol. 409
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
journal, July 2010
- Zhou, T.; Georgiev, I.; Wu, X.
- Science, Vol. 329, Issue 5993
Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16
journal, August 2010
- Doores, Katie J.; Burton, Dennis R.
- Journal of Virology, Vol. 84, Issue 20
Immunologic strategies for HIV-1 remission and eradication
journal, July 2014
- Barouch, D. H.; Deeks, S. G.
- Science, Vol. 345, Issue 6193
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
journal, February 2005
- Cardoso, Rosa M. F.; Zwick, Michael B.; Stanfield, Robyn L.
- Immunity, Vol. 22, Issue 2
A method for identification of HIV gp140 binding memory B cells in human blood
journal, April 2009
- Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas
- Journal of Immunological Methods, Vol. 343, Issue 2
Antibodies in HIV-1 Vaccine Development and Therapy
journal, September 2013
- Klein, F.; Mouquet, H.; Dosenovic, P.
- Science, Vol. 341, Issue 6151
Fc receptor but not complement binding is important in antibody protection against HIV
journal, September 2007
- Hessell, Ann J.; Hangartner, Lars; Hunter, Meredith
- Nature, Vol. 449, Issue 7158
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
journal, October 2012
- Mouquet, H.; Scharf, L.; Euler, Z.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 47
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
journal, October 2013
- Shingai, Masashi; Nishimura, Yoshiaki; Klein, Florian
- Nature, Vol. 503, Issue 7475
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
journal, October 2011
- Pejchal, R.; Doores, K. J.; Walker, L. M.
- Science, Vol. 334, Issue 6059
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
journal, October 2013
- Barouch, Dan H.; Whitney, James B.; Moldt, Brian
- Nature, Vol. 503, Issue 7475
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
journal, May 2012
- Haynes, Barton F.; Kelsoe, Garnett; Harrison, Stephen C.
- Nature Biotechnology, Vol. 30, Issue 5
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
journal, June 2015
- Zhou, Tongqing; Lynch, Rebecca M.; Chen, Lei
- Cell, Vol. 161, Issue 6
Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity
journal, September 2014
- Bournazos, Stylianos; Klein, Florian; Pietzsch, John
- Cell, Vol. 158, Issue 6
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
journal, September 2012
- Kwong, Peter D.; Mascola, John R.
- Immunity, Vol. 37, Issue 3
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
journal, May 2013
- Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J.
- Nature Structural & Molecular Biology, Vol. 20, Issue 7
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
journal, March 2014
- Doria-Rose, Nicole A.; Schramm, Chaim A.; Gorman, Jason
- Nature, Vol. 509, Issue 7498
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
journal, August 2011
- Wu, X.; Zhou, T.; Zhu, J.
- Science, Vol. 333, Issue 6049
Statistical significance for genomewide studies
journal, July 2003
- Storey, J. D.; Tibshirani, R.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 16, p. 9440-9445
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
journal, June 2010
- Pejchal, R.; Walker, L. M.; Stanfield, R. L.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 25
Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection
journal, March 2015
- Saunders, Kevin O.; Pegu, Amarendra; Georgiev, Ivelin S.
- Journal of Virology, Vol. 89, Issue 11
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
journal, May 2013
- Pancera, Marie; Shahzad-ul-Hussan, Syed; Doria-Rose, Nicole A.
- Nature Structural & Molecular Biology, Vol. 20, Issue 7
Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
journal, May 2014
- Scharf, Louise; Scheid, Johannes F.; Lee, Jeong Hyun
- Cell Reports, Vol. 7, Issue 3
Broad neutralization coverage of HIV by multiple highly potent antibodies
journal, September 2011
- Walker, Laura M.; Huber, Michael; Doores, Katie J.
- Nature, Vol. 477, Issue 7365
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
journal, February 2000
- Mascola, John R.; Stiegler, Gabriela; VanCott, Thomas C.
- Nature Medicine, Vol. 6, Issue 2
HIV-1 neutralizing antibodies: understanding nature's pathways
journal, June 2013
- Mascola, John R.; Haynes, Barton F.
- Immunological Reviews, Vol. 254, Issue 1
The Role of Antibodies in HIV Vaccines
journal, March 2010
- Mascola, John R.; Montefiori, David C.
- Annual Review of Immunology, Vol. 28, Issue 1
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
journal, July 2011
- Scheid, J. F.; Mouquet, H.; Ueberheide, B.
- Science, Vol. 333, Issue 6049
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
journal, March 2009
- Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas
- Nature, Vol. 458, Issue 7238
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
journal, November 2014
- Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki
- The Journal of Experimental Medicine, Vol. 211, Issue 12
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
journal, November 2014
- Sok, Devin; van Gils, Marit J.; Pauthner, Matthias
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 49
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
journal, July 2010
- Wu, X.; Yang, Z. -Y.; Li, Y.
- Science, Vol. 329, Issue 5993
Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
journal, November 2009
- Seaman, M. S.; Janes, H.; Hawkins, N.
- Journal of Virology, Vol. 84, Issue 3
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
journal, April 2013
- Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing
- Nature, Vol. 496, Issue 7446
Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies
journal, July 2005
- Li, M.; Gao, F.; Mascola, J. R.
- Journal of Virology, Vol. 79, Issue 16
The Toxicity of Poisons Applied Jointly1
journal, August 1939
- Bliss, C. I.
- Annals of Applied Biology, Vol. 26, Issue 3
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
journal, October 2012
- Klein, Florian; Halper-Stromberg, Ariel; Horwitz, Joshua A.
- Nature, Vol. 492, Issue 7427
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
journal, August 2014
- Rudicell, R. S.; Kwon, Y. D.; Ko, S. -Y.
- Journal of Virology, Vol. 88, Issue 21
Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
journal, June 2010
- Pancera, M.; McLellan, J. S.; Wu, X.
- Journal of Virology, Vol. 84, Issue 16
Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
journal, August 2015
- McCoy, Laura E.; Falkowska, Emilia; Doores, Katie J.
- PLOS Pathogens, Vol. 11, Issue 8
A quantitative basis for antiretroviral therapy for HIV-1 infection
journal, February 2012
- Jilek, Benjamin L.; Zarr, Melissa; Sampah, Maame E.
- Nature Medicine, Vol. 18, Issue 3
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
journal, September 2009
- Walker, L. M.; Phogat, S. K.; Chan-Hui, P. -Y.
- Science, Vol. 326, Issue 5950
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
journal, January 2010
- Corti, Davide; Langedijk, Johannes P. M.; Hinz, Andreas
- PLoS ONE, Vol. 5, Issue 1
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
journal, February 2014
- West, Anthony P.; Scharf, Louise; Scheid, Johannes F.
- Cell, Vol. 156, Issue 4
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
journal, August 2013
- Zhou, Tongqing; Zhu, Jiang; Wu, Xueling
- Immunity, Vol. 39, Issue 2
Structural definition of a conserved neutralization epitope on HIV-1 gp120
journal, February 2007
- Zhou, Tongqing; Xu, Ling; Dey, Barna
- Nature, Vol. 445, Issue 7129
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity
journal, February 2014
- Cimbro, R.; Gallant, T. R.; Dolan, M. A.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 8
Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes
journal, December 2014
- Kong, Rui; Louder, Mark K.; Wagh, Kshitij
- Journal of Virology, Vol. 89, Issue 5
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
journal, January 1993
- Muster, T.; Steindl, F.; Purtscher, M.
- Journal of Virology, Vol. 67, Issue 11
In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer
journal, April 2021
- Lin, Z. Ping; Al Zouabi, Nour N.; Xu, Mark L.
- Scientific Reports, Vol. 11, Issue 1
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
journal, January 2001
- Mascola, John R.; Stiegler, Gabriela; VanCott, Thomas C.
- AIDS, Vol. 15
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
text, January 2013
- Jenny, McDowell,; Quino, Maduro,; Jiang, Zhu,
- The University of North Carolina at Chapel Hill University Libraries
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
text, January 2015
- Aliaksandr, Druz,; F., Scheid, Johannes; R., Burton, Dennis
- The University of North Carolina at Chapel Hill University Libraries
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
text, January 2009
- J., Hessell, A.; P., Poignard,; M., Hunter,
- Nature Publishing Group
Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses
journal, July 2022
- Crowley, Andrew R.; Richardson, Simone I.; Tuyishime, Marina
- Immunogenetics, Vol. 75, Issue 1
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
journal, February 2014
- West, Anthony P.; Scharf, Louise; Scheid, Johannes F.
- Cell, Vol. 156, Issue 4
Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice
journal, August 2014
- Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian
- Cell, Vol. 158, Issue 5
Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity
journal, September 2014
- Bournazos, Stylianos; Klein, Florian; Pietzsch, John
- Cell, Vol. 158, Issue 6
Natural Evolution of Broadly Neutralizing Antibodies
journal, April 2015
- Alter, Galit; Barouch, Dan H.
- Cell, Vol. 161, Issue 3
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
journal, June 2015
- Zhou, Tongqing; Lynch, Rebecca M.; Chen, Lei
- Cell, Vol. 161, Issue 6
A Blueprint for HIV Vaccine Discovery
journal, October 2012
- Burton, Dennis R.; Ahmed, Rafi; Barouch, Dan H.
- Cell Host & Microbe, Vol. 12, Issue 4
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
journal, February 2005
- Cardoso, Rosa M. F.; Zwick, Michael B.; Stanfield, Robyn L.
- Immunity, Vol. 22, Issue 2
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
journal, September 2012
- Kwong, Peter D.; Mascola, John R.
- Immunity, Vol. 37, Issue 3
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
journal, May 2014
- Falkowska, Emilia; Le, Khoa M.; Ramos, Alejandra
- Immunity, Vol. 40, Issue 5
A method for identification of HIV gp140 binding memory B cells in human blood
journal, April 2009
- Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas
- Journal of Immunological Methods, Vol. 343, Issue 2
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1
journal, July 2014
- Sarzotti-Kelsoe, Marcella; Bailer, Robert T.; Turk, Ellen
- Journal of Immunological Methods, Vol. 409
Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors
journal, January 2012
- Ketas, Thomas J.; Holuigue, Sophie; Matthews, Katie
- Virology, Vol. 422, Issue 1
Structural definition of a conserved neutralization epitope on HIV-1 gp120
journal, February 2007
- Zhou, Tongqing; Xu, Ling; Dey, Barna
- Nature, Vol. 445, Issue 7129
Fc receptor but not complement binding is important in antibody protection against HIV
journal, September 2007
- Hessell, Ann J.; Hangartner, Lars; Hunter, Meredith
- Nature, Vol. 449, Issue 7158
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
journal, March 2009
- Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas
- Nature, Vol. 458, Issue 7238
Broad neutralization coverage of HIV by multiple highly potent antibodies
journal, September 2011
- Walker, Laura M.; Huber, Michael; Doores, Katie J.
- Nature, Vol. 477, Issue 7365
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
journal, November 2011
- McLellan, Jason S.; Pancera, Marie; Carrico, Chris
- Nature, Vol. 480, Issue 7377
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
journal, October 2012
- Klein, Florian; Halper-Stromberg, Ariel; Horwitz, Joshua A.
- Nature, Vol. 492, Issue 7427
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
journal, April 2013
- Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing
- Nature, Vol. 496, Issue 7446
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
journal, October 2013
- Barouch, Dan H.; Whitney, James B.; Moldt, Brian
- Nature, Vol. 503, Issue 7475
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
journal, September 2014
- Huang, Jinghe; Kang, Byong H.; Pancera, Marie
- Nature, Vol. 515, Issue 7525
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
journal, August 2014
- Ko, Sung-Youl; Pegu, Amarendra; Rudicell, Rebecca S.
- Nature, Vol. 514, Issue 7524
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
journal, April 2015
- Caskey, Marina; Klein, Florian; Lorenzi, Julio C. C.
- Nature, Vol. 522, Issue 7557
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
journal, May 2012
- Haynes, Barton F.; Kelsoe, Garnett; Harrison, Stephen C.
- Nature Biotechnology, Vol. 30, Issue 5
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
journal, June 2009
- Hessell, Ann J.; Poignard, Pascal; Hunter, Meredith
- Nature Medicine, Vol. 15, Issue 8
A quantitative basis for antiretroviral therapy for HIV-1 infection
journal, February 2012
- Jilek, Benjamin L.; Zarr, Melissa; Sampah, Maame E.
- Nature Medicine, Vol. 18, Issue 3
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
journal, June 2008
- Shen, Lin; Peterson, Susan; Sedaghat, Ahmad R.
- Nature Medicine, Vol. 14, Issue 7
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
journal, August 2013
- Kwong, Peter D.; Mascola, John R.; Nabel, Gary J.
- Nature Reviews Immunology, Vol. 13, Issue 9
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
journal, May 2013
- Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J.
- Nature Structural & Molecular Biology, Vol. 20, Issue 7
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
journal, October 2012
- Moldt, B.; Rakasz, E. G.; Schultz, N.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 46
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
journal, October 2012
- Mouquet, H.; Scharf, L.; Euler, Z.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 47
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
journal, February 2013
- Julien, Jean-Philippe; Lee, Jeong Hyun; Cupo, Albert
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 11
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity
journal, February 2014
- Cimbro, R.; Gallant, T. R.; Dolan, M. A.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 8
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
journal, September 2013
- Horwitz, J. A.; Halper-Stromberg, A.; Mouquet, H.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 41
Statistical significance for genomewide studies
journal, July 2003
- Storey, J. D.; Tibshirani, R.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 16, p. 9440-9445
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
journal, July 2012
- Klein, Florian; Gaebler, Christian; Mouquet, Hugo
- The Journal of Experimental Medicine, Vol. 209, Issue 8
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
journal, November 2014
- Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki
- The Journal of Experimental Medicine, Vol. 211, Issue 12
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
journal, January 2001
- Mascola, John R.; Stiegler, Gabriela; VanCott, Thomas C.
- AIDS, Vol. 15
Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults: VRC01 HIV-1 mAb in healthy adults
journal, September 2015
- Ledgerwood, J. E.; Coates, E. E.; Yamshchikov, G.
- Clinical & Experimental Immunology, Vol. 182, Issue 3
HIV-1 neutralizing antibodies: understanding nature's pathways
journal, June 2013
- Mascola, John R.; Haynes, Barton F.
- Immunological Reviews, Vol. 254, Issue 1
The Toxicity of Poisons Applied Jointly1
journal, August 1939
- Bliss, C. I.
- Annals of Applied Biology, Vol. 26, Issue 3
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
journal, September 2009
- Walker, L. M.; Phogat, S. K.; Chan-Hui, P. -Y.
- Science, Vol. 326, Issue 5950
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
journal, July 2011
- Scheid, J. F.; Mouquet, H.; Ueberheide, B.
- Science, Vol. 333, Issue 6049
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
journal, August 2011
- Wu, X.; Zhou, T.; Zhu, J.
- Science, Vol. 333, Issue 6049
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
journal, October 2011
- Pejchal, R.; Doores, K. J.; Walker, L. M.
- Science, Vol. 334, Issue 6059
Antibodies in HIV-1 Vaccine Development and Therapy
journal, September 2013
- Klein, F.; Mouquet, H.; Dosenovic, P.
- Science, Vol. 341, Issue 6151
Immunologic strategies for HIV-1 remission and eradication
journal, July 2014
- Barouch, D. H.; Deeks, S. G.
- Science, Vol. 345, Issue 6193
Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
journal, May 2014
- Sok, D.; Doores, K. J.; Briney, B.
- Science Translational Medicine, Vol. 6, Issue 236
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
journal, July 2014
- Pegu, A.; Yang, Z. -y.; Boyington, J. C.
- Science Translational Medicine, Vol. 6, Issue 243
Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance
journal, April 2015
- Pritchard, Laura K.; Spencer, Daniel I. R.; Royle, Louise
- Journal of Virology, Vol. 89, Issue 13
A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection
journal, July 2012
- Goo, L.; Jalalian-Lechak, Z.; Richardson, B. A.
- Journal of Virology, Vol. 86, Issue 19
HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes
journal, January 2012
- Doria-Rose, N. A.; Louder, M. K.; Yang, Z.
- Journal of Virology, Vol. 86, Issue 6
The Role of Antibodies in HIV Vaccines
journal, March 2010
- Mascola, John R.; Montefiori, David C.
- Annual Review of Immunology, Vol. 28, Issue 1
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
journal, January 2010
- Corti, Davide; Langedijk, Johannes P. M.; Hinz, Andreas
- PLoS ONE, Vol. 5, Issue 1
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
journal, May 2013
- Julien, Jean-Philippe; Sok, Devin; Khayat, Reza
- PLoS Pathogens, Vol. 9, Issue 5
Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization
journal, July 2014
- Kim, Arthur S.; Leaman, Daniel P.; Zwick, Michael B.
- PLoS Pathogens, Vol. 10, Issue 7
Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
journal, August 2015
- McCoy, Laura E.; Falkowska, Emilia; Doores, Katie J.
- PLOS Pathogens, Vol. 11, Issue 8
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
text, January 2009
- J., Hessell, A.; P., Poignard,; M., Hunter,
- Nature Publishing Group
Works referencing / citing this record:
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
journal, March 2017
- Bonsignori, Mattia; Kreider, Edward F.; Fera, Daniela
- Science Translational Medicine, Vol. 9, Issue 381
Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
journal, November 2019
- Moshoette, Tumelo; Ali, Stuart Alvaro; Papathanasopoulos, Maria Antonia
- Retrovirology, Vol. 16, Issue 1
Neutralization Breadth and Potency of Single-Chain Variable Fragments Derived from Broadly Neutralizing Antibodies Targeting Multiple Epitopes on the HIV-1 Envelope
journal, October 2019
- van Dorsten, Rebecca T.; Lambson, Bronwen E.; Wibmer, Constantinos Kurt
- Journal of Virology, Vol. 94, Issue 2
Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention
journal, January 2017
- Brady, Jacqueline M.; Baltimore, David; Balazs, Alejandro B.
- Immunological Reviews, Vol. 275, Issue 1
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
journal, February 2018
- Steinhardt, James J.; Guenaga, Javier; Turner, Hannah L.
- Nature Communications, Vol. 9, Issue 1
Pharmaceutical Approaches to HIV Treatment and Prevention
journal, July 2018
- Yavuz, Burcin; Morgan, Jessica L.; Showalter, Laura
- Advanced Therapeutics, Vol. 1, Issue 6
A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
journal, January 2020
- Davis-Gardner, Meredith E.; Alfant, Barnett; Weber, Jesse A.
- mBio, Vol. 11, Issue 1
Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time
journal, October 2017
- Hake, Anna; Pfeifer, Nico
- PLOS Computational Biology, Vol. 13, Issue 10
Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing
journal, August 2017
- Thorlund, Kristian; Horwitz, Marc S.; Fife, Brian T.
- BMC Infectious Diseases, Vol. 17, Issue 1
Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity
journal, October 2016
- VanBlargan, Laura A.; Goo, Leslie; Pierson, Theodore C.
- Microbiology and Molecular Biology Reviews, Vol. 80, Issue 4
Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults
journal, January 2018
- Gaudinski, Martin R.; Coates, Emily E.; Houser, Katherine V.
- PLOS Medicine, Vol. 15, Issue 1
Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir
journal, September 2019
- Yu, Wen-Han; Su, David; Torabi, Julia
- JCI Insight, Vol. 4, Issue 17
When two are better than one: Modeling the mechanisms of antibody mixtures
journal, February 2020
- Einav, Tal; Bloom, Jesse D.
- PLOS Computational Biology
Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1
journal, October 2018
- Lin, Allen; Balazs, Alejandro B.
- Retrovirology, Vol. 15, Issue 1
Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02_AG Viruses with a Focus on Evolution over Time
journal, November 2018
- Stefic, Karl; Bouvin-Pley, Mélanie; Essat, Asma
- Journal of Virology, Vol. 93, Issue 2
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
journal, November 2017
- Mayer, Kenneth H.; Seaton, Kelly E.; Huang, Yunda
- PLOS Medicine, Vol. 14, Issue 11
Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections
journal, March 2018
- Wagh, Kshitij; Seaman, Michael S.; Zingg, Marshall
- PLOS Pathogens, Vol. 14, Issue 3
Increasing the Clinical Potential and Applications of Anti-HIV Antibodies
journal, November 2017
- Hua, Casey K.; Ackerman, Margaret E.
- Frontiers in Immunology, Vol. 8
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
journal, July 2016
- Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.
- PLOS Pathogens, Vol. 12, Issue 7
Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development
journal, January 2017
- Bonsignori, Mattia; Liao, Hua-Xin; Gao, Feng
- Immunological Reviews, Vol. 275, Issue 1
Modeling cumulative overall prevention efficacy for the VRC01 phase 2b efficacy trials
journal, May 2018
- Huang, Yunda; Karuna, Shelly; Carpp, Lindsay N.
- Human Vaccines & Immunotherapeutics, Vol. 14, Issue 9
Use of broadly neutralizing antibodies for HIV-1 prevention
journal, January 2017
- Pegu, Amarendra; Hessell, Ann J.; Mascola, John R.
- Immunological Reviews, Vol. 275, Issue 1
Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?
journal, June 2018
- Awi, Noel Jacques; Teow, Sin-Yeang
- Journal of Pathogens, Vol. 2018
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting
journal, January 2017
- Doria-Rose, Nicole A.; Altae-Tran, Han R.; Roark, Ryan S.
- PLOS Pathogens, Vol. 13, Issue 1
Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing
text, January 2017
- Thorlund, Kristian; Horwitz, Marc S.; Fife, Brian T.
- BioMed Central
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
text, January 2017
- Todd, Bradley,; Baptiste, Aussedat,; Amit, Kumar,
- The University of North Carolina at Chapel Hill University Libraries
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting
text, January 2017
- Doria-Rose, Nicole A.; Altae-Tran, Han R.; Roark, Ryan S.
- Columbia University
When two are better than one: Modeling the mechanisms of antibody mixtures
journal, May 2020
- Einav, Tal; Bloom, Jesse D.
- PLOS Computational Biology, Vol. 16, Issue 5
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
text, January 2016
- E., Giorgi, Elena; S., Seaman, Michael; C., Montefiori, David
- The University of North Carolina at Chapel Hill University Libraries
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
text, January 2017
- Mayer, Kenneth H.; Seaton, Kelly E.; Huang, Yunda
- Columbia University
Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System
journal, March 2017
- Bhiman, Jinal N.; Lynch, Rebecca M.
- Current HIV/AIDS Reports, Vol. 14, Issue 2
Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody
journal, February 2018
- Kwon, Young D.; Chuang, Gwo-Yu; Zhang, Baoshan
- Cell Reports, Vol. 22, Issue 7
HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
journal, August 2019
- Bricault, Christine A.; Yusim, Karina; Seaman, Michael S.
- Cell Host & Microbe, Vol. 26, Issue 2
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
journal, November 2019
- Pinto, Dora; Fenwick, Craig; Caillat, Christophe
- Cell Host & Microbe, Vol. 26, Issue 5
AAV-Mediated Expression of Broadly Neutralizing and Vaccine-like Antibodies Targeting the HIV-1 Envelope V2 Region
journal, September 2019
- van den Berg, Fiona T.; Makoah, Nigel A.; Ali, Stuart A.
- Molecular Therapy - Methods & Clinical Development, Vol. 14
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial
journal, April 2019
- Priddy, Frances H.; Lewis, David J. M.; Gelderblom, Huub C.
- The Lancet HIV, Vol. 6, Issue 4
Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
journal, January 2016
- Fuchs, Sebastian P.; Desrosiers, Ronald C.
- Molecular Therapy - Methods & Clinical Development, Vol. 3
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
journal, February 2018
- Steinhardt, James J.; Guenaga, Javier; Turner, Hannah L.
- Nature Communications, Vol. 9, Issue 1
Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals
journal, April 2017
- Cheedarla, Narayanaiah; Precilla, K. Lucia; Babu, Hemalatha
- Scientific Reports, Vol. 7, Issue 1
Engineering antibody-like inhibitors to prevent and treat HIV-1 infection
journal, May 2017
- Gardner, Matthew R.; Farzan, Michael
- Current Opinion in HIV and AIDS, Vol. 12, Issue 3
Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development
journal, January 2017
- Bonsignori, Mattia; Liao, Hua-Xin; Gao, Feng
- Immunological Reviews, Vol. 275, Issue 1
Polyvalent vaccine approaches to combat HIV-1 diversity
journal, January 2017
- Korber, Bette; Hraber, Peter; Wagh, Kshitij
- Immunological Reviews, Vol. 275, Issue 1
A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
journal, January 2020
- Davis-Gardner, Meredith E.; Alfant, Barnett; Weber, Jesse A.
- mBio, Vol. 11, Issue 1
Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?
journal, June 2018
- Awi, Noel Jacques; Teow, Sin-Yeang
- Journal of Pathogens, Vol. 2018
Engineering multi-specific antibodies against HIV-1
journal, August 2018
- Padte, Neal N.; Yu, Jian; Huang, Yaoxing
- Retrovirology, Vol. 15, Issue 1
Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
journal, November 2019
- Moshoette, Tumelo; Ali, Stuart Alvaro; Papathanasopoulos, Maria Antonia
- Retrovirology, Vol. 16, Issue 1
Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials
journal, February 2020
- Reeves, Daniel B.; Huang, Yunda; Duke, Elizabeth R.
- PLOS Computational Biology, Vol. 16, Issue 2
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
journal, November 2017
- Mayer, Kenneth H.; Seaton, Kelly E.; Huang, Yunda
- PLOS Medicine, Vol. 14, Issue 11
Prospects for passive immunity to prevent HIV infection
journal, November 2017
- Morris, Lynn; Mkhize, Nonhlanhla N.
- PLOS Medicine, Vol. 14, Issue 11
Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults
journal, January 2018
- Gaudinski, Martin R.; Coates, Emily E.; Houser, Katherine V.
- PLOS Medicine, Vol. 15, Issue 1
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
journal, July 2016
- Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.
- PLOS Pathogens, Vol. 12, Issue 7
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting
journal, January 2017
- Doria-Rose, Nicole A.; Altae-Tran, Han R.; Roark, Ryan S.
- PLOS Pathogens, Vol. 13, Issue 1
Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success
journal, January 2017
- Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias
- Frontiers in Immunology, Vol. 7
Long-Acting HIV Treatment and Prevention: Closer to the Threshold
journal, June 2017
- Barnhart, Matthew
- Global Health: Science and Practice, Vol. 5, Issue 2