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Title: Nanoscale materials for hyperthermal theranostics

Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc.) that complement and extend the efficacy of traditional chemotherapy and surgery. Our mini review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods.
Authors:
 [1] ;  [2] ;  [3] ;  [4]
  1. Univ. of Washington, Seattle, WA (United States). Dept. of Chemistry
  2. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept.
  3. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept
  4. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept; Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Fundamental & Computational Sciences Directorate
Publication Date:
OSTI Identifier:
1287495
Grant/Contract Number:
AC06-76RLO1830; DGE-1256082; FA95501210400
Type:
Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 7; Journal Issue: 16; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE; Air Force Office of Scientific Research
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE therapeutic approach; nanoscale materials; angiogenesis; DNA-repair; radioemission; optical fluorescence; magnetic resonance; photoacoustic methods