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Title: Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting

Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min-1) by altering the net sonic velocity to reposition acoustic pressure nodes in a simple two-channel device. Finally, the approach is generalizable to other microfluidic platforms for rapid, high-throughput analysis.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5]
  1. Univ. of California, San Francisco, CA (United States). Dept. of Biochemistry and Biophysics; Gladstone Inst., San Francisco, CA (United States)
  2. Univ. of California, San Francisco, CA (United States). Dept. of Biochemistry and Biophysics; Univ. of of California, Berkeley and University of California, San Francisco, CA (United States). Joint Graduate Group in Bioengineering
  3. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Boston Univ., Boston, MA (United States). Dept. of Biomedical Engineering
  4. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  5. Univ. of California, San Francisco, CA (United States). Dept. of Biochemistry and Biophysics; Gladstone Inst., San Francisco, CA (United States); Univ. of of California, Berkeley and University of California, San Francisco, CA (United States). Joint Graduate Group in Bioengineering; Univ. of California, San Francisco, CA (United States). California Inst. for Quantitative Biosciences
Publication Date:
OSTI Identifier:
1282170
Grant/Contract Number:
AC52-07NA2734; 14-LW-077; 1DP1DE024408-01; 1R21A1109611-01A1
Type:
Accepted Manuscript
Journal Name:
Lab on a chip (Print)
Additional Journal Information:
Journal Name: Lab on a chip (Print); Journal Volume: 15; Journal Issue: 4; Journal ID: ISSN 1473-0197
Publisher:
Royal Society of Chemistry
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE; National Inst. of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES