Viral kinetic modeling: state of the art
Abstract
Viral kinetic modeling has led to increased understanding of the within host dynamics of viral infections and the effects of therapy. Here we review recent developments in the modeling of viral infection kinetics with emphasis on two infectious diseases: hepatitis C and influenza. We review how viral kinetic modeling has evolved from simple models of viral infections treated with a drug or drug cocktail with an assumed constant effectiveness to models that incorporate drug pharmacokinetics and pharmacodynamics, as well as phenomenological models that simply assume drugs have time varying-effectiveness. We also discuss multiscale models that include intracellular events in viral replication, models of drug-resistance, models that include innate and adaptive immune responses and models that incorporate cell-to-cell spread of infection. Overall, viral kinetic modeling has provided new insights into the understanding of the disease progression and the modes of action of several drugs. In conclusion, we expect that viral kinetic modeling will be increasingly used in the coming years to optimize drug regimens in order to improve therapeutic outcomes and treatment tolerability for infectious diseases.
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Biology and Biophysics
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1282052
- Grant/Contract Number:
- AC52-06NA25396; R01-AI028433; P20-GM10345; R01-AI078881; R34-HL109334; R01-OD011095
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Pharmacokinetics and Pharmacodynamics
- Additional Journal Information:
- Journal Volume: 41; Journal Issue: 5; Journal ID: ISSN 1567-567X
- Publisher:
- Springer
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; Viral kinetics; Hepatitis C; Influenza; Mathematical modeling; Antiviral drug; Resistance emergence
Citation Formats
Canini, Laetitia, and Perelson, Alan S. Viral kinetic modeling: state of the art. United States: N. p., 2014.
Web. doi:10.1007/s10928-014-9363-3.
Canini, Laetitia, & Perelson, Alan S. Viral kinetic modeling: state of the art. United States. https://doi.org/10.1007/s10928-014-9363-3
Canini, Laetitia, and Perelson, Alan S. Wed .
"Viral kinetic modeling: state of the art". United States. https://doi.org/10.1007/s10928-014-9363-3. https://www.osti.gov/servlets/purl/1282052.
@article{osti_1282052,
title = {Viral kinetic modeling: state of the art},
author = {Canini, Laetitia and Perelson, Alan S.},
abstractNote = {Viral kinetic modeling has led to increased understanding of the within host dynamics of viral infections and the effects of therapy. Here we review recent developments in the modeling of viral infection kinetics with emphasis on two infectious diseases: hepatitis C and influenza. We review how viral kinetic modeling has evolved from simple models of viral infections treated with a drug or drug cocktail with an assumed constant effectiveness to models that incorporate drug pharmacokinetics and pharmacodynamics, as well as phenomenological models that simply assume drugs have time varying-effectiveness. We also discuss multiscale models that include intracellular events in viral replication, models of drug-resistance, models that include innate and adaptive immune responses and models that incorporate cell-to-cell spread of infection. Overall, viral kinetic modeling has provided new insights into the understanding of the disease progression and the modes of action of several drugs. In conclusion, we expect that viral kinetic modeling will be increasingly used in the coming years to optimize drug regimens in order to improve therapeutic outcomes and treatment tolerability for infectious diseases.},
doi = {10.1007/s10928-014-9363-3},
journal = {Journal of Pharmacokinetics and Pharmacodynamics},
number = 5,
volume = 41,
place = {United States},
year = {Wed Jun 25 00:00:00 EDT 2014},
month = {Wed Jun 25 00:00:00 EDT 2014}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 58 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Effects of Aging on Influenza Virus Infection Dynamics
journal, January 2014
- Hernandez-Vargas, E. A.; Wilk, E.; Canini, L.
- Journal of Virology, Vol. 88, Issue 8
Effect of 1918 PB1-F2 Expression on Influenza A Virus Infection Kinetics
journal, February 2011
- Smith, Amber M.; Adler, Frederick R.; McAuley, Julie L.
- PLoS Computational Biology, Vol. 7, Issue 2
A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection
journal, January 2012
- Adiwijaya, Bambang S.; Kieffer, Tara L.; Henshaw, Joshua
- PLoS Computational Biology, Vol. 8, Issue 1
Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: Implications for treatment duration
journal, May 2011
- Guedj, Jeremie; Perelson, Alan S.
- Hepatology, Vol. 53, Issue 6
Modeling Viral and Drug Kinetics: Hepatitis C Virus Treatment with Pegylated Interferon Alfa-2b
journal, January 2003
- ,
- Seminars in Liver Disease, Vol. 23
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
journal, January 1995
- Ho, David D.; Neumann, Avidan U.; Perelson, Alan S.
- Nature, Vol. 373, Issue 6510
Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.
journal, February 1998
- Hayden, F. G.; Fritz, R.; Lobo, M. C.
- Journal of Clinical Investigation, Vol. 101, Issue 3
Differential decay kinetics of human cytomegalovirus glycoprotein B genotypes following antiviral chemotherapy
journal, May 2012
- Emery, Vincent C.; Manuel, Oriol; Asberg, Anders
- Journal of Clinical Virology, Vol. 54, Issue 1
Decay characteristics of HIV-1-infected compartments during combination therapy
journal, May 1997
- Perelson, Alan S.; Essunger, Paulina; Cao, Yunzhen
- Nature, Vol. 387, Issue 6629
Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate
journal, August 2012
- Ribeiro, Ruy M.; Li, Hui; Wang, Shuyi
- PLoS Pathogens, Vol. 8, Issue 8
Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals
journal, November 2013
- Heldt, Frank S.; Frensing, Timo; Pflugmacher, Antje
- PLoS Computational Biology, Vol. 9, Issue 11
Influenza virus aerosol exposure and analytical system for ferrets
journal, May 2011
- Gustin, K. M.; Belser, J. A.; Wadford, D. A.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 20
Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy
journal, June 2000
- Emery, V. C.; Griffiths, P. D.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 14
Modeling viral kinetics and treatment outcome during alisporivir interferon-free treatment in hepatitis C virus genotype 2 and 3 patients: HEPATOLOGY, Vol. XX, NO. X, 2014 GUEDJ ET AL.
journal, April 2014
- Guedj, Jeremie; Yu, Jing; Levi, Micha
- Hepatology, Vol. 59, Issue 5
Inferring Viral Dynamics in Chronically HCV Infected Patients from the Spatial Distribution of Infected Hepatocytes
journal, November 2014
- Graw, Frederik; Balagopal, Ashwin; Kandathil, Abraham J.
- PLoS Computational Biology, Vol. 10, Issue 11
Hepatitis B Virus Kinetics under Antiviral Therapy Sheds Light on Differences in Hepatitis B e Antigen Positive and Negative Infections
journal, November 2010
- Ribeiro, Ruy M.; Germanidis, Georgios; Powers, Kimberly A.
- The Journal of Infectious Diseases, Vol. 202, Issue 9
Hepatitis C Viral Kinetics in the Era of Direct Acting Antiviral Agents and Interleukin-28B
journal, July 2011
- Dahari, Harel; Guedj, Jeremie; Perelson, Alan S.
- Current Hepatitis Reports, Vol. 10, Issue 3
Pharmacodynamics of PEG-IFN-α-2a in HIV/HCV co-infected patients: Implications for treatment outcomes
journal, September 2010
- Dahari, Harel; Affonso de Araujo, Evaldo S.; Haagmans, Bart L.
- Journal of Hepatology, Vol. 53, Issue 3
Towards a quantitative understanding of the within-host dynamics of influenza A infections
journal, March 2009
- Handel, Andreas; Longini, Ira M.; Antia, Rustom
- Journal of The Royal Society Interface, Vol. 7, Issue 42
Dynamics of hepatitis B virus clearance in chimpanzees
journal, November 2005
- Murray, J. M.; Wieland, S. F.; Purcell, R. H.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 49
Modeling amantadine treatment of influenza A virus in vitro
journal, September 2008
- Beauchemin, Catherine A. A.; McSharry, James J.; Drusano, George L.
- Journal of Theoretical Biology, Vol. 254, Issue 2
Quantifying HTLV‐I dynamics
journal, March 2007
- Asquith, Becca; Bangham, Charles R. M.
- Immunology & Cell Biology, Vol. 85, Issue 4
A Hepatitis C Virus Infection Model with Time-Varying Drug Effectiveness: Solution and Analysis
journal, August 2014
- Conway, Jessica M.; Perelson, Alan S.
- PLoS Computational Biology, Vol. 10, Issue 8
FluTE, a Publicly Available Stochastic Influenza Epidemic Simulation Model
journal, January 2010
- Chao, Dennis L.; Halloran, M. Elizabeth; Obenchain, Valerie J.
- PLoS Computational Biology, Vol. 6, Issue 1
Analysis of Hepatitis C Virus Decline during Treatment with the Protease Inhibitor Danoprevir Using a Multiscale Model
journal, March 2013
- Rong, Libin; Guedj, Jeremie; Dahari, Harel
- PLoS Computational Biology, Vol. 9, Issue 3
An in-host model of acute infection: Measles as a case study
journal, February 2008
- Heffernan, J. M.; Keeling, M. J.
- Theoretical Population Biology, Vol. 73, Issue 1
Dynamics of Influenza Virus Infection and Pathology
journal, February 2010
- Saenz, R. A.; Quinlivan, M.; Elton, D.
- Journal of Virology, Vol. 84, Issue 8
Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae
journal, March 2013
- Smith, Amber M.; Adler, Frederick R.; Ribeiro, Ruy M.
- PLoS Pathogens, Vol. 9, Issue 3
Mathematical analysis of multiscale models for hepatitis C virus dynamics under therapy with direct-acting antiviral agents
journal, September 2013
- Rong, Libin; Perelson, Alan S.
- Mathematical Biosciences, Vol. 245, Issue 1
A dynamical model of human immune response to influenza A virus infection
journal, May 2007
- Hancioglu, Baris; Swigon, David; Clermont, Gilles
- Journal of Theoretical Biology, Vol. 246, Issue 1
Kinetics of Influenza A Virus Infection in Humans
journal, July 2006
- Baccam, P.; Beauchemin, C.; Macken, C. A.
- Journal of Virology, Vol. 80, Issue 15
Quantifying the Early Immune Response and Adaptive Immune Response Kinetics in Mice Infected with Influenza A Virus
journal, April 2010
- Miao, H.; Hollenbaugh, J. A.; Zand, M. S.
- Journal of Virology, Vol. 84, Issue 13
Influenza A virus infection kinetics: quantitative data and models: Modeling influenza kinetics
journal, December 2010
- Smith, Amber M.; Perelson, Alan S.
- Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 3, Issue 4
Strategies for containing an emerging influenza pandemic in Southeast Asia
journal, August 2005
- Ferguson, Neil M.; Cummings, Derek A. T.; Cauchemez, Simon
- Nature, Vol. 437, Issue 7056
Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity
journal, August 2013
- Jansen, Christine A.; de Geus, Eveline D.; van Haarlem, Daphne A.
- Scientific Reports, Vol. 3, Issue 1
Combination Antiviral Therapy for Influenza: Predictions From Modeling of Human Infections
journal, March 2012
- Perelson, Alan S.; Rong, Libin; Hayden, Frederick G.
- The Journal of Infectious Diseases, Vol. 205, Issue 11
The impact of fibrosis and steatosis on early viral kinetics in HCV genotype 1-infected patients treated with Peg-IFN-alfa-2a and ribavirin: Impact of liver histology on HCV RNA kinetics
journal, December 2011
- Guedj, H.; Guedj, J.; Negro, F.
- Journal of Viral Hepatitis, Vol. 19, Issue 7
Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
journal, April 2013
- Schiffer, Joshua T.; Swan, David; Al Sallaq, Ramzi
- eLife, Vol. 2
Viral dynamics in hepatitis B virus infection.
journal, April 1996
- Nowak, M. A.; Bonhoeffer, S.; Hill, A. M.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 9
Modelling the kinetics of hepatitis C virus RNA decline over 4 weeks of treatment with pegylated interferon α-2b
journal, May 2008
- Shudo, E.; Ribeiro, R. M.; Perelson, A. S.
- Journal of Viral Hepatitis, Vol. 15, Issue 5
A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure
journal, May 2010
- Snoeck, E.; Chanu, P.; Lavielle, M.
- Clinical Pharmacology & Therapeutics, Vol. 87, Issue 6
Differences in Viral Dynamics between Genotypes 1 and 2 of Hepatitis C Virus
journal, July 2000
- Neumann, Avidan U.; Lam, Nancy P.; Dahari, Harel
- The Journal of Infectious Diseases, Vol. 182, Issue 1
Towards multiscale modeling of influenza infection
journal, September 2013
- Murillo, Lisa N.; Murillo, Michael S.; Perelson, Alan S.
- Journal of Theoretical Biology, Vol. 332
Modeling hepatitis C virus dynamics: Liver regeneration and critical drug efficacy
journal, July 2007
- Dahari, Harel; Lo, Arthur; Ribeiro, Ruy M.
- Journal of Theoretical Biology, Vol. 247, Issue 2
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver
journal, April 2014
- Wieland, Stefan; Makowska, Zuzanna; Campana, Benedetta
- Hepatology, Vol. 59, Issue 6
Modelling cytomegalovirus replication patterns in the human host: factors important for pathogenesis
journal, April 2006
- Regoes, Roland R.; Frances Bowen, E.; Cope, Alethea V.
- Proceedings of the Royal Society B: Biological Sciences, Vol. 273, Issue 1596
The role of cells refractory to productive infection in acute hepatitis B viral dynamics
journal, March 2007
- Ciupe, S. M.; Ribeiro, R. M.; Nelson, P. W.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 12
Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus
journal, May 2010
- Rong, L.; Dahari, H.; Ribeiro, R. M.
- Science Translational Medicine, Vol. 2, Issue 30
IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C
journal, November 2011
- Bochud, P. -Y.; Bibert, S.; Negro, F.
- Journal of Hepatology, Vol. 55, Issue 5
Triphasic decline of hepatitis C virus RNA during antiviral therapy
journal, January 2007
- Dahari, Harel; Ribeiro, Ruy M.; Perelson, Alan S.
- Hepatology, Vol. 46, Issue 1
Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon
journal, June 2003
- Herrmann, E.
- Hepatology, Vol. 37, Issue 6
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
journal, March 1996
- Perelson, A. S.; Neumann, A. U.; Markowitz, M.
- Science, Vol. 271, Issue 5255
Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin
journal, June 2003
- Layden-Almer, J.
- Hepatology, Vol. 37, Issue 6
Dynamics of hepatitis B virus infection
journal, July 2002
- Ribeiro, Ruy M.; Lo, Arthur; Perelson, Alan S.
- Microbes and Infection, Vol. 4, Issue 8
Spatial Aspects of HIV Infection
book, September 2012
- Graw, Frederik; Perelson, Alan S.
- Mathematical Methods and Models in Biomedicine
Analysis of hepatitis B viral load decline under potent therapy: Complex decay profiles observed
journal, November 2001
- Lewin, S.
- Hepatology, Vol. 34, Issue 5
Pharmacodynamics of PEG-IFN α differentiate HIV/HCV coinfected sustained virological responders from nonresponders
journal, May 2006
- Talal, Andrew H.; Ribeiro, Ruy M.; Powers, Kimberly A.
- Hepatology, Vol. 43, Issue 5
Understanding silibinin’s modes of action against HCV using viral kinetic modeling
journal, May 2012
- Guedj, Jeremie; Dahari, Harel; Pohl, Ralf T.
- Journal of Hepatology, Vol. 56, Issue 5
Transmissibility of 1918 pandemic influenza
journal, December 2004
- Mills, Christina E.; Robins, James M.; Lipsitch, Marc
- Nature, Vol. 432, Issue 7019
Modeling complex decay profiles of hepatitis B virus during antiviral therapy
journal, August 2008
- Dahari, Harel; Shudo, Emi; Ribeiro, Ruy M.
- Hepatology, Vol. 49, Issue 1
A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants
journal, April 2010
- Adiwijaya, Bambang S.; Herrmann, Eva; Hare, Brian
- PLoS Computational Biology, Vol. 6, Issue 4
Understanding the symptoms of the common cold and influenza
journal, November 2005
- Eccles, Ron
- The Lancet Infectious Diseases, Vol. 5, Issue 11
Directly transmitted infections diseases: control by vaccination
journal, February 1982
- Anderson, R.; May, R.
- Science, Vol. 215, Issue 4536
Impact of Different Oseltamivir Regimens on Treating Influenza A Virus Infection and Resistance Emergence: Insights from a Modelling Study
journal, April 2014
- Canini, Laetitia; Conway, Jessica M.; Perelson, Alan S.
- PLoS Computational Biology, Vol. 10, Issue 4
Understanding the Dose-Effect Relationship: Clinical Application of Pharmacokinetic-Pharmacodynamic Models
journal, January 1981
- Holford, Nicholas H. G.; Sheiner, Lewis B.
- Clinical Pharmacokinetics, Vol. 6, Issue 6
Modelling viral and immune system dynamics
journal, January 2002
- Perelson, Alan S.
- Nature Reviews Immunology, Vol. 2, Issue 1
Modeling, Clinical and Virology Data From Phase 2 and 3 Studies Support 12-Week Telaprevir Duration in Combination With 24- or 48-Week Peginterferon/Ribavirin
journal, May 2011
- Adiwijaya, Bambang S.; Kieffer, Tara L.; Bartels, Doug J.
- Gastroenterology, Vol. 140, Issue 5
The Kinetics of Mucosal Herpes Simplex Virus–2 Infection in Humans: Evidence for Rapid Viral-Host Interactions
journal, August 2011
- Schiffer, Joshua T.; Wald, Anna; Selke, Stacy
- The Journal of Infectious Diseases, Vol. 204, Issue 4
Modeling HCV kinetics under therapy using PK and PD information
journal, March 2009
- Shudo, Emi; Ribeiro, Ruy M.; Perelson, Alan S.
- Expert Opinion on Drug Metabolism & Toxicology, Vol. 5, Issue 3
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
journal, April 2010
- Gao, Min; Nettles, Richard E.; Belema, Makonen
- Nature, Vol. 465, Issue 7294
A simple cellular automaton model for influenza A viral infections
journal, January 2005
- Beauchemin, Catherine; Samuel, John; Tuszynski, Jack
- Journal of Theoretical Biology, Vol. 232, Issue 2
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon- Therapy
journal, October 1998
- Neumann, A. U.
- Science, Vol. 282, Issue 5386
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
journal, February 2013
- Guedj, J.; Dahari, H.; Rong, L.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 10
Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses
journal, June 2012
- Pawelek, Kasia A.; Huynh, Giao T.; Quinlivan, Michelle
- PLoS Computational Biology, Vol. 8, Issue 6
Neuraminidase Inhibitor Resistance in Influenza: Assessing the Danger of Its Generation and Spread
journal, December 2007
- Handel, Andreas; Longini, Ira M.; Antia, Rustom
- PLoS Computational Biology, Vol. 3, Issue 12
Modeling the mechanisms of acute hepatitis B virus infection
journal, July 2007
- Ciupe, Stanca M.; Ribeiro, Ruy M.; Nelson, Patrick W.
- Journal of Theoretical Biology, Vol. 247, Issue 1
Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms
journal, February 2011
- Lagging, Martin; Askarieh, Galia; Negro, Francesco
- PLoS ONE, Vol. 6, Issue 2
Agent-based modeling of host–pathogen systems: The successes and challenges
journal, April 2009
- Bauer, Amy L.; Beauchemin, Catherine A. A.; Perelson, Alan S.
- Information Sciences, Vol. 179, Issue 10
A perspective on modelling hepatitis C virus infection: A perspective on modelling HCV infection
journal, August 2010
- Guedj, J.; Rong, L.; Dahari, H.
- Journal of Viral Hepatitis, Vol. 17, Issue 12
Modeling the interaction of cytotoxic T lymphocytes and influenza
virus infected epithelial cells
journal, January 2010
- Tridane, Abdessamad; Kuang, Yang
- Mathematical Biosciences and Engineering, Vol. 7, Issue 1, p. 171-185
Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)
journal, February 2012
- Guedj, Jeremie; Dahari, Harel; Shudo, Emi
- Hepatology, Vol. 55, Issue 4
Viral dynamics in human immunodeficiency virus type 1 infection
journal, January 1995
- Wei, Xiping; Ghosh, Sajal K.; Taylor, Maria E.
- Nature, Vol. 373, Issue 6510
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
journal, March 2013
- Schiffer, Joshua T.; Corey, Lawrence
- Nature Medicine, Vol. 19, Issue 3
Use of Laser Capture Microdissection to Map Hepatitis C Virus–Positive Hepatocytes in Human Liver
journal, December 2013
- Kandathil, Abraham J.; Graw, Frederik; Quinn, Jeffrey
- Gastroenterology, Vol. 145, Issue 6
Modeling Quasispecies and Drug Resistance in Hepatitis C Patients Treated with a Protease Inhibitor
journal, May 2012
- Rong, Libin; Ribeiro, Ruy M.; Perelson, Alan S.
- Bulletin of Mathematical Biology, Vol. 74, Issue 8
Global Transcriptome Analysis in Influenza-Infected Mouse Lungs Reveals the Kinetics of Innate and Adaptive Host Immune Responses
journal, July 2012
- Pommerenke, Claudia; Wilk, Esther; Srivastava, Barkha
- PLoS ONE, Vol. 7, Issue 7
Mathematical Model of Antiviral Immune Response III. Influenza A Virus Infection
journal, April 1994
- Bocharov, G. A.; Romanyukha, A. A.
- Journal of Theoretical Biology, Vol. 167, Issue 4
Rates of Spontaneous Mutation
journal, April 1998
- Drake, John W.; Charlesworth, Brian; Charlesworth, Deborah
- Genetics, Vol. 148, Issue 4
Works referencing / citing this record:
A Robust and Efficient Numerical Method for RNA-Mediated Viral Dynamics
journal, October 2017
- Reinharz, Vladimir; Churkin, Alexander; Dahari, Harel
- Frontiers in Applied Mathematics and Statistics, Vol. 3
A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents
journal, April 2018
- Quintela, Barbara de M.; Conway, Jessica M.; Hyman, James M.
- Frontiers in Microbiology, Vol. 9
Mathematical Analysis of Viral Replication Dynamics and Antiviral Treatment Strategies: From Basic Models to Age-Based Multi-Scale Modeling
journal, July 2018
- Zitzmann, Carolin; Kaderali, Lars
- Frontiers in Microbiology, Vol. 9
Towards a multi-level and a multi-disciplinary approach to DNA oncovirus virulence
journal, April 2019
- Alizon, Samuel; Bravo, Ignacio G.; Farrell, Paul J.
- Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 374, Issue 1773
Parameter estimation in mathematical models of viral infections using R
posted_content, April 2017
- Nguyen, Van Kinh; Hernandez-Vargas, Esteban A.
- bioRxiv
Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies
journal, August 2017
- Best, Katharine; Guedj, Jeremie; Madelain, Vincent
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 33
Special Issue “Mathematical Modeling of Viral Infections”
journal, June 2018
- Murray, John; Ribeiro, Ruy
- Viruses, Vol. 10, Issue 6
Mathematical Models for Immunology: Current State of the Art and Future Research Directions
journal, October 2016
- Eftimie, Raluca; Gillard, Joseph J.; Cantrell, Doreen A.
- Bulletin of Mathematical Biology, Vol. 78, Issue 10
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
journal, January 2016
- Madelain, Vincent; Nguyen, Thi Huyen Tram; Olivo, Anaelle
- Clinical Pharmacokinetics, Vol. 55, Issue 8
Towards a multi-level and a multi-disciplinary approach to DNA oncovirus virulence
journal, April 2019
- Alizon, Samuel; Bravo, Ignacio G.; Farrell, Paul J.
- Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 374, Issue 1773
Natural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study
journal, June 2019
- Murall, Carmen Lía; Rahmoun, Massilva; Selinger, Christian
- BMJ Open, Vol. 9, Issue 6
Kinetics of Double-Stranded DNA Viremia After Allogeneic Hematopoietic Cell Transplantation
journal, September 2017
- Hill, Joshua A.; Mayer, Bryan T.; Xie, Hu
- Clinical Infectious Diseases, Vol. 66, Issue 3
Mathematical Models for Immunology: Current State of the Art and Future Research Directions
journal, October 2016
- Eftimie, Raluca; Gillard, Joseph J.; Cantrell, Doreen A.
- Bulletin of Mathematical Biology, Vol. 78, Issue 10
In-host modeling
journal, May 2017
- Ciupe, Stanca M.; Heffernan, Jane M.
- Infectious Disease Modelling, Vol. 2, Issue 2
Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death
journal, March 2018
- Jackson, Laurelle; Hunter, Jessica; Cele, Sandile
- eLife, Vol. 7
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
journal, January 2016
- Madelain, Vincent; Nguyen, Thi Huyen Tram; Olivo, Anaelle
- Clinical Pharmacokinetics, Vol. 55, Issue 8
Ebola virus dynamics in mice treated with favipiravir
journal, November 2015
- Madelain, Vincent; Oestereich, Lisa; Graw, Frederik
- Antiviral Research, Vol. 123
Towards a Multiscale Model of Acute HIV Infection
journal, January 2017
- Bouchnita, Anass; Bocharov, Gennady; Meyerhans, Andreas
- Computation, Vol. 5, Issue 4
Special Issue “Mathematical Modeling of Viral Infections”
journal, June 2018
- Murray, John; Ribeiro, Ruy
- Viruses, Vol. 10, Issue 6
Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection
journal, June 2016
- Boianelli, Alessandro; Sharma-Chawla, Niharika; Bruder, Dunja
- Frontiers in Cellular and Infection Microbiology, Vol. 6
Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans
journal, October 2018
- Patel, Kashyap; Kirkpatrick, Carl M.; Nieforth, Keith A.
- Journal of Antimicrobial Chemotherapy, Vol. 74, Issue 2
Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death
posted_content, July 2017
- Jackson, Laurelle; Hunter, Jessica; Cele, Sandile
- bioRxiv
Antiviral interferon response at single-cell resolution
journal, August 2018
- Talemi, Soheil Rastgou; Höfer, Thomas
- Immunological Reviews, Vol. 285, Issue 1
A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study
journal, May 2020
- Hart, W. S.; Maini, P. K.; Yates, C. A.
- Journal of The Royal Society Interface, Vol. 17, Issue 166
Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats
journal, November 2019
- Wethington, Darren; Harder, Olivia; Uppulury, Karthik
- Journal of The Royal Society Interface, Vol. 16, Issue 160
Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death
posted_content, July 2017
- Jackson, Laurelle; Hunter, Jessica; Cele, Sandile
- bioRxiv
Spatiotemporal Dynamics of Virus Infection Spreading in Tissues
journal, December 2016
- Bocharov, Gennady; Meyerhans, Andreas; Bessonov, Nickolai
- PLOS ONE, Vol. 11, Issue 12