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Title: Dynamic functional imaging of brain glucose utilization using fPET-FDG

We report that glucose is the principal source of energy for the brain and yet the dynamic response of glucose utilization to changes in brain activity is still not fully understood. Positron emission tomography (PET) allows quantitative measurement of glucose metabolism using 2-[18F]-fluorodeoxyglucose (FDG). However, FDG PET in its current form provides an integral (or average) of glucose consumption over tens of minutes and lacks the temporal information to capture physiological alterations associated with changes in brain activity induced by tasks or drug challenges. Traditionally, changes in glucose utilization are inferred by comparing two separate scans, which significantly limits the utility of the method. We report a novel method to track changes in FDG metabolism dynamically, with higher temporal resolution than exists to date and within a single session. Using a constant infusion of FDG, we demonstrate that our technique (termed fPET-FDG) can be used in an analysis pipeline similar to fMRI to define within-session differential metabolic responses. We use visual stimulation to demonstrate the feasibility of this method. Ultimately, this new method has a great potential to be used in research protocols and clinical settings since fPET-FDG imaging can be performed with most PET scanners and data acquisition andmore » analysis are straightforward. fPET-FDG is a highly complementary technique to MRI and provides a rich new way to observe functional changes in brain metabolism.« less
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [1] ;  [1] ;  [3] ;  [4] ;  [5]
  1. Massachusetts General Hospital, Charlestown, MA (United States). Dept. of Radiology
  2. Massachusetts General Hospital, Charlestown, MA (United States). Dept. of Radiology; Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Electrical Engineering and Computer Science
  3. Brookhaven National Lab. (BNL), Upton, NY (United States). Biosciences Dept.
  4. Massachusetts General Hospital, Charlestown, MA (United States). Dept. of Radiology; Harvard-Massachusetts Institute of Technology, Cambridge, MA (United States). Division of Health Sciences and Technology
  5. Massachusetts General Hospital, Charlestown, MA (United States). Dept. of Radiology; Brookhaven National Lab. (BNL), Upton, NY (United States). Biosciences Dept.
Publication Date:
OSTI Identifier:
1281964
Grant/Contract Number:
SC0008430; P41EB015896; S10RR019933; R01EB014894
Type:
Accepted Manuscript
Journal Name:
NeuroImage (Orlando, Fla)
Additional Journal Information:
Journal Name: NeuroImage (Orlando, Fla); Journal Volume: 100; Journal Issue: C; Journal ID: ISSN 1053-8119
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE; National Inst. of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION 2-[18F]-fluorodeoxyglucose (FDG); Glucose utilization; Visual stimulus; MR/PET; PET