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Title: Sensitivity analysis for dose deposition in radiotherapy via a Fokker–Planck model

In this paper, we study the sensitivities of electron dose calculations with respect to stopping power and transport coefficients. We focus on the application to radiotherapy simulations. We use a Fokker–Planck approximation to the Boltzmann transport equation. Equations for the sensitivities are derived by the adjoint method. The Fokker–Planck equation and its adjoint are solved numerically in slab geometry using the spherical harmonics expansion (PN) and an Harten-Lax-van Leer finite volume method. Our method is verified by comparison to finite difference approximations of the sensitivities. Finally, we present numerical results of the sensitivities for the normalized average dose deposition depth with respect to the stopping power and the transport coefficients, demonstrating the increase in relative sensitivities as beam energy decreases. In conclusion, this in turn gives estimates on the uncertainty in the normalized average deposition depth, which we present.
Authors:
 [1] ;  [2] ;  [2]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. RWTH Aachen Univ., Aachen (Germany)
Publication Date:
OSTI Identifier:
1267026
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Mathematical Medicine and Biology
Additional Journal Information:
Journal Name: Mathematical Medicine and Biology; Journal ID: ISSN 1477-8599
Publisher:
Institute of Mathematics and its Applications (IMA)
Research Org:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
ORNL Program Development; USDOE
Country of Publication:
United States
Language:
English
Subject:
97 MATHEMATICS AND COMPUTING; 59 BASIC BIOLOGICAL SCIENCES radiotherapy simulation; sensitivity analysis; Fokker-Planck; adjoint method; deterministic dose calculations; average deposition depth