A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Abstract
Devices resident in the stomach used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. In the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. We determine that these enteric elastomers should increase the safety profile for a wide range of gastricretentive devices.
- Authors:
-
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Harvard Medical School, Boston, MA (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Texas A & M Univ., College Station, TX (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1265875
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Materials
- Additional Journal Information:
- Journal Volume: 14; Journal Issue: 10; Journal ID: ISSN 1476-1122
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; hydrogel; gastric devices; synchrotron x-ray scattering
Citation Formats
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, and Traverso, Giovanni. A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. United States: N. p., 2015.
Web. doi:10.1038/nmat4355.
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, & Traverso, Giovanni. A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. United States. https://doi.org/10.1038/nmat4355
Zhang, Shiyi, Bellinger, Andrew M., Glettig, Dean L., Barman, Ross, Lee, Young-Ah Lucy, Zhu, Jiahua, Cleveland, Cody, Montgomery, Veronica A., Gu, Li, Nash, Landon D., Maitland, Duncan J., Langer, Robert, and Traverso, Giovanni. Mon .
"A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices". United States. https://doi.org/10.1038/nmat4355. https://www.osti.gov/servlets/purl/1265875.
@article{osti_1265875,
title = {A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices},
author = {Zhang, Shiyi and Bellinger, Andrew M. and Glettig, Dean L. and Barman, Ross and Lee, Young-Ah Lucy and Zhu, Jiahua and Cleveland, Cody and Montgomery, Veronica A. and Gu, Li and Nash, Landon D. and Maitland, Duncan J. and Langer, Robert and Traverso, Giovanni},
abstractNote = {Devices resident in the stomach used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. In the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. We determine that these enteric elastomers should increase the safety profile for a wide range of gastricretentive devices.},
doi = {10.1038/nmat4355},
journal = {Nature Materials},
number = 10,
volume = 14,
place = {United States},
year = {Mon Jul 27 00:00:00 EDT 2015},
month = {Mon Jul 27 00:00:00 EDT 2015}
}
Web of Science
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Recent Development of pH-Responsive Polymers for Cancer Nanomedicine
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