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Title: Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer.
Authors:
 [1] ;  [2]
  1. Cuttler & Associates, Vaughan, ON (Canada)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
OSTI Identifier:
1263484
Type:
Accepted Manuscript
Journal Name:
Dose-Response
Additional Journal Information:
Journal Volume: 13; Journal Issue: -1; Journal ID: ISSN 1559-3258
Publisher:
International Hormesis Society
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES plutonium-dioxide; inhalation; lung cancer; prophylaxis; radiation hormesis; adaptive protection