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Title: Extremely high-rate, uniform dissolution of alloy C-22 in anhydrous organic solutions at room temperature

During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 filter dryer was observed after single, short (several hours) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of C-22. More detailed mass loss studies showed initial corrosion rates exceeding25 mm/year that then decreased over several hours to steady state rates of 3-5 mm/year. The corrosion was highly uniform. Electrochemical measurements demonstrated that although C-22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. Furthermore, DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the C-22 well into the transpassive region, leading to the observed high corrosion rates.
Authors:
 [1] ;  [2] ;  [2] ;  [3]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  2. Teva Branded Pharmaceuticals, Malvern, PA (United States)
  3. Univ. of Virginia, Charlottesville, VA (United States)
Publication Date:
OSTI Identifier:
1259672
Report Number(s):
SAND--2016-2348J
Journal ID: ISSN 0010-9312; 621995
Grant/Contract Number:
AC04-94AL85000
Type:
Accepted Manuscript
Journal Name:
Corrosion
Additional Journal Information:
Journal Name: Corrosion; Journal ID: ISSN 0010-9312
Publisher:
NACE International
Research Org:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE hastelloy C22; nickel; chromium; molybdenum; transpassivity; alloy 22; organic solvent; non-aqueous; hydrochloric acid; quinone