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Title: ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular focus on fluorine-18 (18F). The key to the system is the combination of a radiation detector measuring radioactivity concentration, in line with a peristaltic pump dispensing known volumes. Results show the combined system demonstrates volume variation to be within 5 % for dispensing volumes of 20 μL or greater. When considering volumes of 20 μL or greater, the delivered radioactivity is in agreement with the requested amount as measured independently with a dose calibrator to within 2 % on average. In conclusion, the integration of the detector and pump in an in-line system leads to a flexible and compact approach that can accurately dispense solutions containing radioactivity concentrations ranging from the high values typical of [18F]fluoride directly produced from a cyclotron (~0.1-1 mCi μL-1) to the low values typical of batches of [18F]fluoride-labeled radiotracers intended for preclinical mouse scans (~1-10 μCi μL-1).
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [3]
  1. Univ. of California, Los Angeles, CA (United States). Crump Institute for Molecular Imaging; Univ. of California, Los Angeles, CA (United States). Dept. of Molecular & Medical Pharmacology; Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  2. Carroll and Ramsey Associates, Berkeley, CA (United States)
  3. Univ. of California, Los Angeles, CA (United States). Crump Institute for Molecular Imaging; Univ. of California, Los Angeles, CA (United States). Dept. of Molecular & Medical Pharmacology
Publication Date:
OSTI Identifier:
1259519
Grant/Contract Number:
SC0001249; R25T CA098010
Type:
Accepted Manuscript
Journal Name:
EJNMMI Research
Additional Journal Information:
Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2191-219X
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING