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Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology
Publication Date:
OSTI Identifier:
1258588
Type:
Accepted Manuscript
Journal Name:
Viruses
Additional Journal Information:
Journal Volume: 8; Journal Issue: 4; Journal ID: ISSN 1999-4915
Publisher:
MDPI
Research Org:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States); Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology
Sponsoring Org:
USDOE; Centers for Disease Control and Prevention
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES Crimean-Congo hemorrhagic fever; viral hemorrhagic fever; reverse genetics; pathogenesis; tick-borne virus