Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy
Abstract
A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model. We found the drug’s hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug’s compatibility; as a result, we achieved better antitumour efficacy. Lastly, our results help elucidate nanomedicines’ in vivo fate and provide guidelines for efficient drug delivery.
- Authors:
-
- Icahn School of Medicine at Mount Sinai, New York, NY (United States)
- IcaIcahn School of Medicine at Mount Sinai, New York, NY (United States)
- The Norwegian Univ. of Science and Technology, Trondheim, (Norway)
- Weill Cornell Medical College of Cornell Univ., New York, NY (United States); IBM Thomas J. Watson Research Center, Yorktown Heights, NY (United States)
- Icahn School of Medicine at Mount Sinai, New York, NY (United States); Academic Medical Center, Amsterdam (The Netherlands)
- Weill Cornell Medical College of Cornell Univ., New York, NY (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); UT-Battelle LLC/ORNL, Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1258344
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 7; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Zhao, Yiming, Fay, Francois, Hak, Sjoerd, Manuel Perez-Aguilar, Jose, Sanchez-Gaytan, Brenda L., Goode, Brandon, Duivenvoorden, Raphael, de Lange Davies, Catharina, Bjorkoy, Astrid, Weinstein, Harel, Fayad, Zahi A., Perez-Medina, Carlos, and Mulder, Willem J. M. Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy. United States: N. p., 2016.
Web. doi:10.1038/ncomms11221.
Zhao, Yiming, Fay, Francois, Hak, Sjoerd, Manuel Perez-Aguilar, Jose, Sanchez-Gaytan, Brenda L., Goode, Brandon, Duivenvoorden, Raphael, de Lange Davies, Catharina, Bjorkoy, Astrid, Weinstein, Harel, Fayad, Zahi A., Perez-Medina, Carlos, & Mulder, Willem J. M. Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy. United States. https://doi.org/10.1038/ncomms11221
Zhao, Yiming, Fay, Francois, Hak, Sjoerd, Manuel Perez-Aguilar, Jose, Sanchez-Gaytan, Brenda L., Goode, Brandon, Duivenvoorden, Raphael, de Lange Davies, Catharina, Bjorkoy, Astrid, Weinstein, Harel, Fayad, Zahi A., Perez-Medina, Carlos, and Mulder, Willem J. M. Wed .
"Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy". United States. https://doi.org/10.1038/ncomms11221. https://www.osti.gov/servlets/purl/1258344.
@article{osti_1258344,
title = {Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy},
author = {Zhao, Yiming and Fay, Francois and Hak, Sjoerd and Manuel Perez-Aguilar, Jose and Sanchez-Gaytan, Brenda L. and Goode, Brandon and Duivenvoorden, Raphael and de Lange Davies, Catharina and Bjorkoy, Astrid and Weinstein, Harel and Fayad, Zahi A. and Perez-Medina, Carlos and Mulder, Willem J. M.},
abstractNote = {A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model. We found the drug’s hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug’s compatibility; as a result, we achieved better antitumour efficacy. Lastly, our results help elucidate nanomedicines’ in vivo fate and provide guidelines for efficient drug delivery.},
doi = {10.1038/ncomms11221},
journal = {Nature Communications},
number = ,
volume = 7,
place = {United States},
year = {Wed Apr 13 00:00:00 EDT 2016},
month = {Wed Apr 13 00:00:00 EDT 2016}
}
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Works referenced in this record:
Phase I and Pharmacokinetic Study of Genexol-PM, a Cremophor-Free, Polymeric Micelle-Formulated Paclitaxel, in Patients with Advanced Malignancies
journal, June 2004
- Kim, T. -Y.
- Clinical Cancer Research, Vol. 10, Issue 11
Nanotechnology Applications in Cancer
journal, August 2007
- Nie, Shuming; Xing, Yun; Kim, Gloria J.
- Annual Review of Biomedical Engineering, Vol. 9, Issue 1
Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection
journal, November 2009
- Andrew MacKay, J.; Chen, Mingnan; McDaniel, Jonathan R.
- Nature Materials, Vol. 8, Issue 12
Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells
journal, April 2011
- Wang, Feng; Wang, Yu-Cai; Dou, Shuang
- ACS Nano, Vol. 5, Issue 5
Understanding biophysicochemical interactions at the nano–bio interface
journal, June 2009
- Nel, Andre E.; Mädler, Lutz; Velegol, Darrell
- Nature Materials, Vol. 8, Issue 7
Near-Infrared Fluorescence Energy Transfer Imaging of Nanoparticle Accumulation and Dissociation Kinetics in Tumor-Bearing Mice
journal, October 2013
- Zhao, Yiming; van Rooy, Inge; Hak, Sjoerd
- ACS Nano, Vol. 7, Issue 11
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
journal, October 2011
- Cabral, H.; Matsumoto, Y.; Mizuno, K.
- Nature Nanotechnology, Vol. 6, Issue 12
Copolymer Micelles and Nanospheres with Different In Vitro Stability Demonstrate Similar Paclitaxel Pharmacokinetics
journal, January 2012
- Letchford, Kevin; Burt, Helen M.
- Molecular Pharmaceutics, Vol. 9, Issue 2
Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π–Π Stacking Stabilized Polymeric Micelles
journal, February 2015
- Shi, Yang; van der Meel, Roy; Theek, Benjamin
- ACS Nano, Vol. 9, Issue 4
Principles of nanoparticle design for overcoming biological barriers to drug delivery
journal, September 2015
- Blanco, Elvin; Shen, Haifa; Ferrari, Mauro
- Nature Biotechnology, Vol. 33, Issue 9
Fast Release of Lipophilic Agents from Circulating PEG-PDLLA Micelles Revealed by in Vivo Förster Resonance Energy Transfer Imaging
journal, May 2008
- Chen, Hongtao; Kim, Sungwon; He, Wei
- Langmuir, Vol. 24, Issue 10
Scalable molecular dynamics with NAMD
journal, January 2005
- Phillips, James C.; Braun, Rosemary; Wang, Wei
- Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802
Identifying Mechanisms of Interfacial Dynamics Using Single-Molecule Tracking
journal, July 2012
- Kastantin, Mark; Walder, Robert; Schwartz, Daniel K.
- Langmuir, Vol. 28, Issue 34
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging
journal, May 2012
- Hak, Sjoerd; Helgesen, Emily; Hektoen, Helga H.
- ACS Nano, Vol. 6, Issue 6
Comparison of simple potential functions for simulating liquid water
journal, July 1983
- Jorgensen, William L.; Chandrasekhar, Jayaraman; Madura, Jeffry D.
- The Journal of Chemical Physics, Vol. 79, Issue 2
Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs
book, January 2013
- Ahmed, Naveed; Mora-Huertas, C. E.; Jaafar-Maalej, Chiraz
- Drug Delivery Strategies for Poorly Water‐Soluble Drugs
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
Can drug molecules diffuse into the core of micelles?
journal, January 2012
- Guo, Xin Dong; Qian, Yu; Zhang, Can Yang
- Soft Matter, Vol. 8, Issue 39
Self-Assembled Delivery Vehicles for Poorly Water-Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts
book, January 2013
- May, Sylvio; Fahr, Alfred
- Drug Delivery Strategies for Poorly Water‐Soluble Drugs
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
journal, April 2012
- Hrkach, J.; Von Hoff, D.; Ali, M. M.
- Science Translational Medicine, Vol. 4, Issue 128
Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells
journal, December 2011
- Liu, Zhi-Gang; Liu, Li; Xu, Li-Hua
- Oncology Reports, Vol. 27, Issue 4
Constant pressure molecular dynamics simulation: The Langevin piston method
journal, September 1995
- Feller, Scott E.; Zhang, Yuhong; Pastor, Richard W.
- The Journal of Chemical Physics, Vol. 103, Issue 11
Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)‐block‐polycaprolactone diblock copolymer micelles: Theoretical and experimental data and correlations
journal, March 2008
- Letchford, Kevin; Liggins, Richard; Burt, Helen
- Journal of Pharmaceutical Sciences, Vol. 97, Issue 3
Nanonization strategies for poorly water-soluble drugs
journal, April 2011
- Chen, Huabing; Khemtong, Chalermchai; Yang, Xiangliang
- Drug Discovery Today, Vol. 16, Issue 7-8, p. 354-360
A holistic approach to targeting disease with polymeric nanoparticles
journal, January 2015
- Cheng, Christopher J.; Tietjen, Gregory T.; Saucier-Sawyer, Jennifer K.
- Nature Reviews Drug Discovery, Vol. 14, Issue 4
Spatiotemporal controlled delivery of nanoparticles to injured vasculature
journal, January 2010
- Chan, J. M.; Zhang, L.; Tong, R.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 5
Treating metastatic cancer with nanotechnology
journal, December 2011
- Schroeder, Avi; Heller, Daniel A.; Winslow, Monte M.
- Nature Reviews Cancer, Vol. 12, Issue 1
Quantum Dot and Cy5.5 Labeled Nanoparticles to Investigate Lipoprotein Biointeractions via Förster Resonance Energy Transfer
journal, December 2010
- Skajaa, Torjus; Zhao, Yiming; van den Heuvel, Dave J.
- Nano Letters, Vol. 10, Issue 12
Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle–cell interaction
journal, December 2009
- Kim, Sungwon; Shi, Yunzhou; Kim, Ji Young
- Expert Opinion on Drug Delivery, Vol. 7, Issue 1
HPMA copolymers with pH-controlled release of doxorubicin
journal, February 2003
- Ulbrich, K.; Etrych, T.; Chytil, P.
- Journal of Controlled Release, Vol. 87, Issue 1-3
In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration
journal, March 2007
- Liu, Jubo; Zeng, Faquan; Allen, Christine
- European Journal of Pharmaceutics and Biopharmaceutics, Vol. 65, Issue 3
Probing Hydrophobic Interactions Using Trajectories of Amphiphilic Molecules at a Hydrophobic/Water Interface
journal, April 2009
- Honciuc, Andrei; Schwartz, Daniel K.
- Journal of the American Chemical Society, Vol. 131, Issue 16
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
journal, January 2012
- Kamaly, Nazila; Xiao, Zeyu; Valencia, Pedro M.
- Chemical Society Reviews, Vol. 41, Issue 7
Partial solubility parameters of poly(d,l-lactide-co-glycolide)
journal, November 2004
- Schenderlein, S.; Lück, M.; Müller, B. W.
- International Journal of Pharmaceutics, Vol. 286, Issue 1-2
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
journal, October 2014
- Torchilin, Vladimir P.
- Nature Reviews Drug Discovery, Vol. 13, Issue 11
Probing Lipid Coating Dynamics of Quantum Dot Core Micelles via Förster Resonance Energy Transfer
journal, December 2013
- Zhao, Yiming; Schapotschnikow, Philipp; Skajaa, Torjus
- Small, Vol. 10, Issue 6
Doxil® — The first FDA-approved nano-drug: Lessons learned
journal, June 2012
- Barenholz, Yechezkel (Chezy)
- Journal of Controlled Release, Vol. 160, Issue 2
pH-sensitive drug loading/releasing in amphiphilic copolymer PAE–PEG: Integrating molecular dynamics and dissipative particle dynamics simulations
journal, August 2012
- Luo, Zhonglin; Jiang, Jianwen
- Journal of Controlled Release, Vol. 162, Issue 1
Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine
journal, January 2004
- Liu, Jubo; Xiao, Yuehua; Allen, Christine
- Journal of Pharmaceutical Sciences, Vol. 93, Issue 1
Nanoparticulate Assemblies of Amphiphiles and Diagnostically Active Materials for Multimodality Imaging
journal, July 2009
- Mulder, Willem J. M.; Strijkers, Gustav J.; van Tilborg, Geralda A. F.
- Accounts of Chemical Research, Vol. 42, Issue 7
Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles
journal, June 2008
- Tong, Rong; Cheng, Jianjun
- Angewandte Chemie International Edition, Vol. 47, Issue 26
A drug-specific nanocarrier design for efficient anticancer therapy
journal, July 2015
- Shi, Changying; Guo, Dandan; Xiao, Kai
- Nature Communications, Vol. 6, Issue 1
The Rule of Five Revisited: Applying Log D in Place of Log P in Drug-Likeness Filters
journal, August 2007
- Bhal, Sanjivanjit K.; Kassam, Karim; Peirson, Ian G.
- Molecular Pharmaceutics, Vol. 4, Issue 4
Steered molecular dynamics and mechanical functions of proteins
journal, April 2001
- Isralewitz, Barry; Gao, Mu; Schulten, Klaus
- Current Opinion in Structural Biology, Vol. 11, Issue 2
Solubilization of ?guest? molecules into polymeric aggregates
journal, January 2001
- Nagarajan, R.
- Polymers for Advanced Technologies, Vol. 12, Issue 1-2
Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)
journal, December 2012
- Tong, Rong; Gabrielson, Nathan P.; Fan, Timothy M.
- Current Opinion in Solid State and Materials Science, Vol. 16, Issue 6
Free energy calculation from steered molecular dynamics simulations using Jarzynski’s equality
journal, August 2003
- Park, Sanghyun; Khalili-Araghi, Fatemeh; Tajkhorshid, Emad
- The Journal of Chemical Physics, Vol. 119, Issue 6
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
journal, September 2007
- Bartlett, D. W.; Su, H.; Hildebrandt, I. J.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 39
Multifunctional Nanoemulsion Platform for Imaging Guided Therapy Evaluated in Experimental Cancer
journal, May 2011
- Gianella, Anita; Jarzyna, Peter A.; Mani, Venkatesh
- ACS Nano, Vol. 5, Issue 6
Fast lipoprotein chromatography: new method of analysis for plasma lipoproteins
journal, November 1993
- März, W.; Siekmeier, R.; Scharnagl, H.
- Clinical Chemistry, Vol. 39, Issue 11
Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles
journal, June 2008
- Tong, Rong; Cheng, Jianjun
- Angewandte Chemie, Vol. 120, Issue 26
Scalable molecular dynamics with NAMD
journal, January 2005
- Phillips, James C.; Braun, Rosemary; Wang, Wei
- Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802
CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
journal, January 2009
- Vanommeslaeghe, K.; Hatcher, E.; Acharya, C.
- Journal of Computational Chemistry
Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine
journal, January 2004
- Liu, Jubo; Xiao, Yuehua; Allen, Christine
- Journal of Pharmaceutical Sciences, Vol. 93, Issue 1
Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)‐block‐polycaprolactone diblock copolymer micelles: Theoretical and experimental data and correlations
journal, March 2008
- Letchford, Kevin; Liggins, Richard; Burt, Helen
- Journal of Pharmaceutical Sciences, Vol. 97, Issue 3
Probing Lipid Coating Dynamics of Quantum Dot Core Micelles via Förster Resonance Energy Transfer
journal, December 2013
- Zhao, Yiming; Schapotschnikow, Philipp; Skajaa, Torjus
- Small, Vol. 10, Issue 6
Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)
journal, December 2012
- Tong, Rong; Gabrielson, Nathan P.; Fan, Timothy M.
- Current Opinion in Solid State and Materials Science, Vol. 16, Issue 6
Nanonization strategies for poorly water-soluble drugs
journal, April 2011
- Chen, Huabing; Khemtong, Chalermchai; Yang, Xiangliang
- Drug Discovery Today, Vol. 16, Issue 7-8, p. 354-360
In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration
journal, March 2007
- Liu, Jubo; Zeng, Faquan; Allen, Christine
- European Journal of Pharmaceutics and Biopharmaceutics, Vol. 65, Issue 3
Partial solubility parameters of poly(d,l-lactide-co-glycolide)
journal, November 2004
- Schenderlein, S.; Lück, M.; Müller, B. W.
- International Journal of Pharmaceutics, Vol. 286, Issue 1-2
Doxil® — The first FDA-approved nano-drug: Lessons learned
journal, June 2012
- Barenholz, Yechezkel (Chezy)
- Journal of Controlled Release, Vol. 160, Issue 2
pH-sensitive drug loading/releasing in amphiphilic copolymer PAE–PEG: Integrating molecular dynamics and dissipative particle dynamics simulations
journal, August 2012
- Luo, Zhonglin; Jiang, Jianwen
- Journal of Controlled Release, Vol. 162, Issue 1
Interaction of drugs with bovine and human serum albumin
journal, September 2002
- Sułkowska, Anna
- Journal of Molecular Structure, Vol. 614, Issue 1-3
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
journal, July 2002
- Yoo, Hyuk Sang; Lee, Eun Ah; Park, Tae Gwan
- Journal of Controlled Release, Vol. 82, Issue 1
Nanoparticulate Assemblies of Amphiphiles and Diagnostically Active Materials for Multimodality Imaging
journal, July 2009
- Mulder, Willem J. M.; Strijkers, Gustav J.; van Tilborg, Geralda A. F.
- Accounts of Chemical Research, Vol. 42, Issue 7
Identifying Mechanisms of Interfacial Dynamics Using Single-Molecule Tracking
journal, July 2012
- Kastantin, Mark; Walder, Robert; Schwartz, Daniel K.
- Langmuir, Vol. 28, Issue 34
Fast Release of Lipophilic Agents from Circulating PEG-PDLLA Micelles Revealed by in Vivo Förster Resonance Energy Transfer Imaging
journal, May 2008
- Chen, Hongtao; Kim, Sungwon; He, Wei
- Langmuir, Vol. 24, Issue 10
The Rule of Five Revisited: Applying Log D in Place of Log P in Drug-Likeness Filters
journal, August 2007
- Bhal, Sanjivanjit K.; Kassam, Karim; Peirson, Ian G.
- Molecular Pharmaceutics, Vol. 4, Issue 4
Copolymer Micelles and Nanospheres with Different In Vitro Stability Demonstrate Similar Paclitaxel Pharmacokinetics
journal, January 2012
- Letchford, Kevin; Burt, Helen M.
- Molecular Pharmaceutics, Vol. 9, Issue 2
Quantum Dot and Cy5.5 Labeled Nanoparticles to Investigate Lipoprotein Biointeractions via Förster Resonance Energy Transfer
journal, December 2010
- Skajaa, Torjus; Zhao, Yiming; van den Heuvel, Dave J.
- Nano Letters, Vol. 10, Issue 12
Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells
journal, April 2011
- Wang, Feng; Wang, Yu-Cai; Dou, Shuang
- ACS Nano, Vol. 5, Issue 5
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging
journal, May 2012
- Hak, Sjoerd; Helgesen, Emily; Hektoen, Helga H.
- ACS Nano, Vol. 6, Issue 6
Near-Infrared Fluorescence Energy Transfer Imaging of Nanoparticle Accumulation and Dissociation Kinetics in Tumor-Bearing Mice
journal, October 2013
- Zhao, Yiming; van Rooy, Inge; Hak, Sjoerd
- ACS Nano, Vol. 7, Issue 11
A drug-specific nanocarrier design for efficient anticancer therapy
journal, July 2015
- Shi, Changying; Guo, Dandan; Xiao, Kai
- Nature Communications, Vol. 6, Issue 1
Understanding biophysicochemical interactions at the nano–bio interface
journal, June 2009
- Nel, Andre E.; Mädler, Lutz; Velegol, Darrell
- Nature Materials, Vol. 8, Issue 7
Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection
journal, November 2009
- Andrew MacKay, J.; Chen, Mingnan; McDaniel, Jonathan R.
- Nature Materials, Vol. 8, Issue 12
Treating metastatic cancer with nanotechnology
journal, December 2011
- Schroeder, Avi; Heller, Daniel A.; Winslow, Monte M.
- Nature Reviews Cancer, Vol. 12, Issue 1
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
journal, January 2012
- Kamaly, Nazila; Xiao, Zeyu; Valencia, Pedro M.
- Chemical Society Reviews, Vol. 41, Issue 7
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
journal, September 2007
- Bartlett, D. W.; Su, H.; Hildebrandt, I. J.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 39
Spatiotemporal controlled delivery of nanoparticles to injured vasculature
journal, January 2010
- Chan, J. M.; Zhang, L.; Tong, R.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 5
Nanotechnology Applications in Cancer
journal, August 2007
- Nie, Shuming; Xing, Yun; Kim, Gloria J.
- Annual Review of Biomedical Engineering, Vol. 9, Issue 1
Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle–cell interaction
journal, December 2009
- Kim, Sungwon; Shi, Yunzhou; Kim, Ji Young
- Expert Opinion on Drug Delivery, Vol. 7, Issue 1
Comparison of the therapeutic efficacy of 188Rhenium-liposomes and liposomal doxorubicin in a 4T1 murine orthotopic breast cancer model
journal, November 2011
- Lee, Te-Wei
- Oncology Reports
Works referencing / citing this record:
A Step-by-Step Multiple Stimuli-Responsive Nanoplatform for Enhancing Combined Chemo-Photodynamic Therapy
journal, January 2017
- Wang, Yi; Wei, Guoqing; Zhang, Xiaobin
- Advanced Materials, Vol. 29, Issue 12
Tunable Hydrophile–Lipophile Balance for Manipulating Structural Stability and Tumor Retention of Amphiphilic Nanoparticles
journal, July 2019
- Zheng, Xiuli; Pan, Dayi; Chen, Miao
- Advanced Materials, Vol. 31, Issue 35
Smart cancer nanomedicine
journal, November 2019
- van der Meel, Roy; Sulheim, Einar; Shi, Yang
- Nature Nanotechnology, Vol. 14, Issue 11
Therapeutic targeting of trained immunity
journal, April 2019
- Mulder, Willem J. M.; Ochando, Jordi; Joosten, Leo A. B.
- Nature Reviews Drug Discovery, Vol. 18, Issue 7
Facile dynamic one-step modular assembly based on boronic acid-diol for construction of a micellar drug delivery system
journal, January 2018
- Zhao, Zekai; Zhang, Ying; Tian, Chunli
- Biomaterials Science, Vol. 6, Issue 10
Investigating supramolecular systems using Förster resonance energy transfer
journal, January 2018
- Teunissen, Abraham J. P.; Pérez-Medina, Carlos; Meijerink, Andries
- Chemical Society Reviews, Vol. 47, Issue 18
In situ real-time tracing of hierarchical targeting nanostructures in drug resistant tumors using diffuse fluorescence tomography
journal, January 2019
- Guo, Qianqian; Wang, Yangyun; Zhang, Limin
- Chemical Science, Vol. 10, Issue 34
Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery
journal, January 2020
- van der Meel, Roy; Chen, Sam; Zaifman, Josh
- Small
Inhalation of peptide-loaded nanoparticles improves heart failure
journal, January 2018
- Miragoli, Michele; Ceriotti, Paola; Iafisco, Michele
- Science Translational Medicine, Vol. 10, Issue 424
pH-Sensitive Micelles Based on Star Copolymer Ad-(PCL-b-PDEAEMA-b-PPEGMA)4 for Controlled Drug Delivery
journal, April 2018
- Yang, Huiyan; Guo, Jianwei; Tong, Rui
- Polymers, Vol. 10, Issue 4
Overcoming the Limits of Flash Nanoprecipitation: Effective Loading of Hydrophilic Drug into Polymeric Nanoparticles with Controlled Structure
journal, October 2018
- Massella, Daniele; Celasco, Edvige; Salaün, Fabien
- Polymers, Vol. 10, Issue 10
pH-Responsive Micelles Assembled by Three-Armed Degradable Block Copolymers with a Cholic Acid Core for Drug Controlled-Release
journal, March 2019
- Feng, Jingjie; Wen, Weiqiu; Jia, Yong-Guang
- Polymers, Vol. 11, Issue 3
Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery
journal, August 2021
- Meel, Roy; Chen, Sam; Zaifman, Josh
- Small, Vol. 17, Issue 37
Förster Resonance Energy Transfer-Based Stability Assessment of PLGA Nanoparticles in Vitro and in Vivo
journal, January 2019
- Swider, Edyta; Maharjan, Sanish; Houkes, Karlijne
- ACS Applied Bio Materials, Vol. 2, Issue 3
Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release
journal, August 2017
- Maiolo, Daniele; Pigliacelli, Claudia; Sánchez Moreno, Paola
- ACS Nano, Vol. 11, Issue 9
Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy
journal, October 2018
- Bouchaala, Redouane; Richert, Ludovic; Anton, Nicolas
- ACS Omega, Vol. 3, Issue 10
pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics
journal, March 2020
- Palanikumar, L.; Al-Hosani, Sumaya; Kalmouni, Mona
- Communications Biology, Vol. 3, Issue 1
pH-Sensitive Micelles Based on Star Copolymer Ad-(PCL-b-PDEAEMA-b-PPEGMA)4 for Controlled Drug Delivery
journal, April 2018
- Yang, Huiyan; Guo, Jianwei; Tong, Rui
- Polymers, Vol. 10, Issue 4
Overcoming the Limits of Flash Nanoprecipitation: Effective Loading of Hydrophilic Drug into Polymeric Nanoparticles with Controlled Structure
journal, October 2018
- Massella, Daniele; Celasco, Edvige; Salaün, Fabien
- Polymers, Vol. 10, Issue 10
Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment
journal, January 2017
- Chen, Binlong; Dai, Wenbing; He, Bing
- Theranostics, Vol. 7, Issue 3
Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations
journal, January 2017
- Wang, Hangxiang; Chen, Jianmei; Xu, Chang
- Theranostics, Vol. 7, Issue 15
Polylactide-tethered prodrugs in polymeric nanoparticles as reliable nanomedicines for the efficient eradication of patient-derived hepatocellular carcinoma
journal, January 2018
- Wang, Hangxiang; Zhou, Liqian; Xie, Ke
- Theranostics, Vol. 8, Issue 14