Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines
Abstract
© 2016 Stoiber et al. Steroid hormones induce cascades of gene activation and repression with transformative effects on cell fate . Steroid transduction plays a major role in the development and physiology of nearly all metazoan species, and in the progression of the most common forms of cancer. Despite the paramount importance of steroids in developmental and translational biology, a complete map of transcriptional response has not been developed for any hormone . In the case of 20-hydroxyecdysone (ecdysone) in Drosophila melanogaster, these trajectories range from apoptosis to immortalization. We mapped the ecdysone transduction network in a cohort of 41 cell lines, the largest such atlas yet assembled. We found that the early transcriptional response mirrors the distinctiveness of physiological origins: genes respond in restricted patterns, conditional on the expression levels of dozens of transcription factors. Only a small cohort of genes is constitutively modulated independent of initial cell state. Ecdysone-responsive genes tend to organize into directional same-stranded units, with consecutive genes induced from the same strand. Here, we identify half of the ecdysone receptor heterodimer as the primary rate-limiting step in the response, and find that initial receptor isoform levels modulate the activated cohort of target transcription factors. Thismore »
- Authors:
-
- Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Indiana Univ., Bloomington, IN (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1257389
- Alternate Identifier(s):
- OSTI ID: 1378726
- Grant/Contract Number:
- AC02-05CH11231; R01 GM076655
- Resource Type:
- Accepted Manuscript
- Journal Name:
- G3
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 3; Journal ID: ISSN 2160-1836
- Publisher:
- Genetics Society of America
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Stoiber, Marcus, Celniker, Susan, Cherbas, Lucy, Brown, Ben, and Cherbas, Peter. Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines. United States: N. p., 2016.
Web. doi:10.1534/g3.115.023366.
Stoiber, Marcus, Celniker, Susan, Cherbas, Lucy, Brown, Ben, & Cherbas, Peter. Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines. United States. https://doi.org/10.1534/g3.115.023366
Stoiber, Marcus, Celniker, Susan, Cherbas, Lucy, Brown, Ben, and Cherbas, Peter. Fri .
"Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines". United States. https://doi.org/10.1534/g3.115.023366. https://www.osti.gov/servlets/purl/1257389.
@article{osti_1257389,
title = {Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines},
author = {Stoiber, Marcus and Celniker, Susan and Cherbas, Lucy and Brown, Ben and Cherbas, Peter},
abstractNote = {© 2016 Stoiber et al. Steroid hormones induce cascades of gene activation and repression with transformative effects on cell fate . Steroid transduction plays a major role in the development and physiology of nearly all metazoan species, and in the progression of the most common forms of cancer. Despite the paramount importance of steroids in developmental and translational biology, a complete map of transcriptional response has not been developed for any hormone . In the case of 20-hydroxyecdysone (ecdysone) in Drosophila melanogaster, these trajectories range from apoptosis to immortalization. We mapped the ecdysone transduction network in a cohort of 41 cell lines, the largest such atlas yet assembled. We found that the early transcriptional response mirrors the distinctiveness of physiological origins: genes respond in restricted patterns, conditional on the expression levels of dozens of transcription factors. Only a small cohort of genes is constitutively modulated independent of initial cell state. Ecdysone-responsive genes tend to organize into directional same-stranded units, with consecutive genes induced from the same strand. Here, we identify half of the ecdysone receptor heterodimer as the primary rate-limiting step in the response, and find that initial receptor isoform levels modulate the activated cohort of target transcription factors. This atlas of steroid response reveals organizing principles of gene regulation by a model type II nuclear receptor and lays the foundation for comprehensive and predictive understanding of the ecdysone transduction network in the fruit fly.},
doi = {10.1534/g3.115.023366},
journal = {G3},
number = 3,
volume = 6,
place = {United States},
year = {Fri Jan 15 00:00:00 EST 2016},
month = {Fri Jan 15 00:00:00 EST 2016}
}
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Works referenced in this record:
Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters
journal, April 2012
- Kellner, Wendy A.; Ramos, Edward; Van Bortle, Kevin
- Genome Research, Vol. 22, Issue 6
Jupiter, a newDrosophila protein associated with microtubules
journal, January 2006
- Karpova, Nina; Bobinnec, Yves; Fouix, Sylvaine
- Cell Motility and the Cytoskeleton, Vol. 63, Issue 5
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner
journal, March 2014
- Chodankar, R.; Wu, D. -Y.; Schiller, B. J.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 11
Hormonal Regulation of the E75 Gene in Drosophila: Identifying Functional Regulatory Elements through Computational and Biological Analysis
journal, April 2009
- Bernardo, Travis J.; Dubrovskaya, Veronica A.; Jannat, Habiba
- Journal of Molecular Biology, Vol. 387, Issue 4
The Putzig-NURF Nucleosome Remodeling Complex Is Required for Ecdysone Receptor Signaling and Innate Immunity in Drosophila melanogaster
journal, March 2011
- Kugler, Sabrina J.; Gehring, Eva-Maria; Wallkamm, Veronika
- Genetics, Vol. 188, Issue 1
Ecdysteroid-inducible polypeptides in a Drosophila cell line
journal, December 1980
- Savakis, C.; Demetri, G.; Cherbas, P.
- Cell, Vol. 22, Issue 3
Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development
journal, October 2005
- Vanolst, L.
- Development, Vol. 132, Issue 19
Differential expression analysis for sequence count data
journal, October 2010
- Anders, Simon; Huber, Wolfgang
- Genome Biology, Vol. 11, Issue 10
Detecting differential usage of exons from RNA-seq data
journal, June 2012
- Anders, S.; Reyes, A.; Huber, W.
- Genome Research, Vol. 22, Issue 10
Ecdysone Induced Gene Expression Is Associated with Acetylation of Histone H3 Lysine 23 in Drosophila melanogaster
journal, July 2012
- Bodai, László; Zsindely, Nóra; Gáspár, Renáta
- PLoS ONE, Vol. 7, Issue 7
Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2
journal, August 2012
- Gauthier, Sebastien A.; VanHaaften, Eric; Cherbas, Lucy
- PLoS Genetics, Vol. 8, Issue 8
Tissue-Specific Gene Expression and Ecdysone-Regulated Genomic Networks in Drosophila
journal, July 2003
- Li, Tong-Ruei; White, Kevin P.
- Developmental Cell, Vol. 5, Issue 1
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor
journal, December 2009
- Sawatsubashi, S.; Murata, T.; Lim, J.
- Genes & Development, Vol. 24, Issue 2
Haploid cell cultures of Drosophila melanogaster
journal, July 1978
- Debec, A.
- Nature, Vol. 274, Issue 5668
Identification of ecdysone response elements by analysis of the Drosophila Eip28/29 gene.
journal, January 1991
- Cherbas, L.; Lee, K.; Cherbas, P.
- Genes & Development, Vol. 5, Issue 1
Troubleshooting Microarray Hybridizations
book, January 2006
- Eads, Brian; Cash, Amy; Bogart, Kevin
- Methods in Enzymology
Morphological and chromosomal characterization of three new continuous cell lines of Drosophila melanogaster
journal, January 1972
- Mosna, Giuliana; Dolfini, Silvana
- Chromosoma, Vol. 38, Issue 1
Arthropod nuclear receptors and their role in molting: Arthropod nuclear receptors
journal, September 2009
- Nakagawa, Yoshiaki; Henrich, Vincent C.
- FEBS Journal, Vol. 276, Issue 21
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
journal, September 2012
- Derrien, T.; Johnson, R.; Bussotti, G.
- Genome Research, Vol. 22, Issue 9
Neurite elongation from Drosophila neural BG2-c6 cells stimulated by 20-hydroxyecdysone
journal, October 2010
- Tominaga, Makoto; Nishihara, Eri; Oogami, Takahiro
- Neuroscience Letters, Vol. 482, Issue 3
SMRTER, a Drosophila Nuclear Receptor Coregulator, Reveals that EcR-Mediated Repression Is Critical for Development
journal, August 1999
- Tsai, Chih-Cheng; Kao, Hung-Ying; Yao, Tso-Pang
- Molecular Cell, Vol. 4, Issue 2
Differential expression analysis for sequence count data
journal, April 2010
- Anders, Simon; Huber, Wolfgang
- Nature Precedings
Hormone-response Genes Are Direct in Vivo Regulatory Targets of Brahma (SWI/SNF) Complex Function
journal, September 2006
- Zraly, Claudia B.; Middleton, Frank A.; Dingwall, Andrew K.
- Journal of Biological Chemistry, Vol. 281, Issue 46
Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
journal, November 2003
- Sedkov, Yurii; Cho, Elizabeth; Petruk, Svetlana
- Nature, Vol. 426, Issue 6962
Cell lines derived from late embryonic stages of Drosophila melanogaster
journal, April 1972
- Schneider, Imogene
- Development, Vol. 27, Issue 2
Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines
journal, February 2012
- Justiniano, Steven E.; Mathew, Anne; Mitra, Sayan
- PLoS ONE, Vol. 7, Issue 2
DNA affects ligand binding of the ecdysone receptor of Drosophila melanogaster
journal, May 2009
- Azoitei, Anca; Spindler-Barth, Margarethe
- Molecular and Cellular Endocrinology, Vol. 303, Issue 1-2
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues
journal, June 2004
- Cakouros, Dimitrios; Daish, Tasman J.; Kumar, Sharad
- Journal of Cell Biology, Vol. 165, Issue 5
Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster
journal, September 2011
- Gonsalves, Sarah E.; Neal, Scott J.; Kehoe, Amy S.
- BMC Genomics, Vol. 12, Issue 1
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
journal, December 1993
- Yao, Tso-Pang; Forman, Barry Marc; Jiang, Zeyu
- Nature, Vol. 366, Issue 6454
The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit
journal, March 2012
- Zraly, Claudia B.; Dingwall, Andrew K.
- Nucleic Acids Research, Vol. 40, Issue 13
Targeting bromodomains: epigenetic readers of lysine acetylation
journal, April 2014
- Filippakopoulos, Panagis; Knapp, Stefan
- Nature Reviews Drug Discovery, Vol. 13, Issue 5
26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors.
journal, April 1988
- Cherbas, P.; Cherbas, L.; Lee, S. S.
- Proceedings of the National Academy of Sciences, Vol. 85, Issue 7
Ecdysone and the cell cycle: Investigations in a mosquito cell line
journal, October 2010
- Fallon, Ann M.; Gerenday, Anna
- Journal of Insect Physiology, Vol. 56, Issue 10
Establishment of stable cell lines of Drosophila germ-line stem cells
journal, October 2006
- Niki, Y.; Yamaguchi, T.; Mahowald, A. P.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 44
Pri peptides are mediators of ecdysone for the temporal control of development
journal, October 2014
- Chanut-Delalande, Hélène; Hashimoto, Yoshiko; Pelissier-Monier, Anne
- Nature Cell Biology, Vol. 16, Issue 11
Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster
journal, September 2011
- Gonsalves, Sarah E.; Neal, Scott J.; Kehoe, Amy S.
- BMC Genomics, Vol. 12, Issue 1
Multiple O -glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
journal, July 2011
- Leonardi, Jessica; Fernandez-Valdivia, Rodrigo; Li, Yi-Dong
- Development, Vol. 138, Issue 16
The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis
journal, January 2005
- Beckstead, Robert B.; Lam, Geanette; Thummel, Carl S.
- Genome Biology, Vol. 6, Issue 12, p. R99
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor
journal, December 2009
- Sawatsubashi, S.; Murata, T.; Lim, J.
- Genes & Development, Vol. 24, Issue 2
The transcriptional diversity of 25 Drosophila cell lines
journal, December 2010
- Cherbas, L.; Willingham, A.; Zhang, D.
- Genome Research, Vol. 21, Issue 2
Tissue-specific regulation by ecdysone: Distinct patterns ofEip28/29 expression are controlled by different ecdysone response elements
journal, January 1994
- Andres, Andrew J.; Cherbas, Peter
- Developmental Genetics, Vol. 15, Issue 4
DNA copy number evolution in Drosophila cell lines
journal, August 2014
- Lee, Hangnoh; McManus, C. Joel; Cho, Dong-Yeon
- Genome Biology, Vol. 15, Issue 8
Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily
journal, May 1999
- Dressel, Uwe; Thormeyer, Dorit; Altincicek, Boran
- Molecular and Cellular Biology, Vol. 19, Issue 5
FlyBase 102—advanced approaches to interrogating FlyBase
journal, November 2013
- St. Pierre, Susan E.; Ponting, Laura; Stefancsik, Raymund
- Nucleic Acids Research, Vol. 42, Issue D1
Cell lines from imaginal discs ofDrosophila melanogaster
journal, October 1987
- Ui, K.; Ueda, R.; Miyake, T.
- In Vitro Cellular & Developmental Biology, Vol. 23, Issue 10
Spatial expression of transcription factors in Drosophila embryonic organ development
journal, January 2013
- Hammonds, Ann S.; Bristow, Christopher A.; Fisher, William W.
- Genome Biology, Vol. 14, Issue 12
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
journal, May 2010
- Heinz, Sven; Benner, Christopher; Spann, Nathanael
- Molecular Cell, Vol. 38, Issue 4
Detecting differential usage of exons from RNA-seq data
journal, June 2012
- Anders, S.; Reyes, A.; Huber, W.
- Genome Research, Vol. 22, Issue 10
DNA-binding properties of Drosophila ecdysone receptor isoforms and their modification by the heterodimerization partner ultraspiracle
journal, November 2009
- Braun, Simone; Azoitei, Anca; Spindler-Barth, Margarethe
- Archives of Insect Biochemistry and Physiology, Vol. 72, Issue 3
The Steroid Hormone Ecdysone Functions with Intrinsic Chromatin Remodeling Factors to Control Female Germline Stem Cells in Drosophila
journal, November 2010
- Ables, Elizabeth T.; Drummond-Barbosa, Daniela
- Cell Stem Cell, Vol. 7, Issue 5
Genomic mapping of binding regions for the Ecdysone receptor protein complex
journal, February 2009
- Gauhar, Z.; Sun, L. V.; Hua, S.
- Genome Research, Vol. 19, Issue 6
Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters
journal, April 2012
- Kellner, Wendy A.; Ramos, Edward; Van Bortle, Kevin
- Genome Research, Vol. 22, Issue 6
Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2
journal, August 2012
- Gauthier, Sebastien A.; VanHaaften, Eric; Cherbas, Lucy
- PLoS Genetics, Vol. 8, Issue 8
Ecdysone Induced Gene Expression Is Associated with Acetylation of Histone H3 Lysine 23 in Drosophila melanogaster
journal, July 2012
- Bodai, László; Zsindely, Nóra; Gáspár, Renáta
- PLoS ONE, Vol. 7, Issue 7
Hormonal Regulation of the E75 Gene in Drosophila: Identifying Functional Regulatory Elements through Computational and Biological Analysis
journal, April 2009
- Bernardo, Travis J.; Dubrovskaya, Veronica A.; Jannat, Habiba
- Journal of Molecular Biology, Vol. 387, Issue 4
Jupiter, a newDrosophila protein associated with microtubules
journal, January 2006
- Karpova, Nina; Bobinnec, Yves; Fouix, Sylvaine
- Cell Motility and the Cytoskeleton, Vol. 63, Issue 5
Ecdysone-mediated Up-regulation of the Effector Caspase DRICE Is Required for Hormone-dependent Apoptosis in Drosophila Cells
journal, January 2005
- Kilpatrick, Z. E.; Cakouros, D.; Kumar, S.
- Journal of Biological Chemistry, Vol. 280, Issue 12
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner
journal, March 2014
- Chodankar, R.; Wu, D. -Y.; Schiller, B. J.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 11
Ecdysteroid-inducible polypeptides in a Drosophila cell line
journal, December 1980
- Savakis, C.; Demetri, G.; Cherbas, P.
- Cell, Vol. 22, Issue 3
Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines
journal, January 2011
- Davis, Melissa B.; SanGil, Inigo; Berry, Grace
- BMC Developmental Biology, Vol. 11, Issue 1
Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
journal, November 2003
- Sedkov, Yurii; Cho, Elizabeth; Petruk, Svetlana
- Nature, Vol. 426, Issue 6962
Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines
journal, February 2012
- Justiniano, Steven E.; Mathew, Anne; Mitra, Sayan
- PLoS ONE, Vol. 7, Issue 2
The Competence Factor βFtz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator
journal, October 2006
- Zhu, Jinsong; Chen, Li; Sun, Guoqiang
- Molecular and Cellular Biology, Vol. 26, Issue 24
Genetic Control of Specificity to Steroid-Triggered Responses in Drosophila
journal, December 2013
- Ihry, Robert J.; Bashirullah, Arash
- Genetics, Vol. 196, Issue 3
Efficient Genetic Method for Establishing Drosophila Cell Lines Unlocks the Potential to Create Lines of Specific Genotypes
journal, August 2008
- Simcox, Amanda; Mitra, Sayan; Truesdell, Sharon
- PLoS Genetics, Vol. 4, Issue 8
Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines
text, January 2011
- Nevis, Lori; Olayokun, Rashidat; Davis, Melissa B.
- Columbia University
Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development
journal, December 1992
- Andres, Andrew J.; Cherbas, Peter
- Development, Vol. 116, Issue 4
The transcriptional diversity of 25 Drosophila cell lines
journal, December 2010
- Cherbas, L.; Willingham, A.; Zhang, D.
- Genome Research, Vol. 21, Issue 2
DNA copy number evolution in Drosophila cell lines
journal, August 2014
- Lee, Hangnoh; McManus, C. Joel; Cho, Dong-Yeon
- Genome Biology, Vol. 15, Issue 8
Quantifying similarity between motifs
journal, January 2007
- Gupta, Shobhit; Stamatoyannopoulos, John A.; Bailey, Timothy L.
- Genome Biology, Vol. 8, Issue 2
Tissue-specific regulation by ecdysone: Distinct patterns ofEip28/29 expression are controlled by different ecdysone response elements
journal, January 1994
- Andres, Andrew J.; Cherbas, Peter
- Developmental Genetics, Vol. 15, Issue 4
Haploid cell cultures of Drosophila melanogaster
journal, July 1978
- Debec, A.
- Nature, Vol. 274, Issue 5668
Hormone-Responsive Enhancer-Activity Maps Reveal Predictive Motifs, Indirect Repression, and Targeting of Closed Chromatin
journal, April 2014
- Shlyueva, Daria; Stelzer, Christoph; Gerlach, Daniel
- Molecular Cell, Vol. 54, Issue 1
Discovering the complexity of the metazoan transcriptome
journal, January 2014
- Hangauer, Matthew J.; Carpenter, Susan; McManus, Michael T.
- Genome Biology, Vol. 15, Issue 4
Diversity and dynamics of the Drosophila transcriptome
journal, March 2014
- Brown, James B.; Boley, Nathan; Eisman, Robert
- Nature, Vol. 512, Issue 7515
EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue
journal, January 2003
- Cherbas, L.
- Development, Vol. 130, Issue 2
DNA-binding properties of Drosophila ecdysone receptor isoforms and their modification by the heterodimerization partner ultraspiracle
journal, November 2009
- Braun, Simone; Azoitei, Anca; Spindler-Barth, Margarethe
- Archives of Insect Biochemistry and Physiology, Vol. 72, Issue 3
Pri peptides are mediators of ecdysone for the temporal control of development
journal, October 2014
- Chanut-Delalande, Hélène; Hashimoto, Yoshiko; Pelissier-Monier, Anne
- Nature Cell Biology, Vol. 16, Issue 11
Identification of ecdysone response elements by analysis of the Drosophila Eip28/29 gene.
journal, January 1991
- Cherbas, L.; Lee, K.; Cherbas, P.
- Genes & Development, Vol. 5, Issue 1
Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development
journal, October 2005
- Vanolst, L.
- Development, Vol. 132, Issue 19
Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
journal, February 2013
- Carbonell, Albert; Mazo, Alexander; Serras, Florenci
- Molecular Biology of the Cell, Vol. 24, Issue 3
Sequential gene activation by ecdysone in polytene chromosomes of Drosophila melanogaster
journal, November 1973
- Ashburner, Michael
- Developmental Biology, Vol. 35, Issue 1
Spatial expression of transcription factors in Drosophila embryonic organ development
journal, January 2013
- Hammonds, Ann S.; Bristow, Christopher A.; Fisher, William W.
- Genome Biology, Vol. 14, Issue 12
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
journal, October 1991
- Koelle, Michael R.; Talbot, William S.; Segraves, William A.
- Cell, Vol. 67, Issue 1
Ecdysone and the cell cycle: Investigations in a mosquito cell line
journal, October 2010
- Fallon, Ann M.; Gerenday, Anna
- Journal of Insect Physiology, Vol. 56, Issue 10
DNA affects ligand binding of the ecdysone receptor of Drosophila melanogaster
journal, May 2009
- Azoitei, Anca; Spindler-Barth, Margarethe
- Molecular and Cellular Endocrinology, Vol. 303, Issue 1-2
Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity
journal, October 2010
- Garbuzov, Alina; Tatar, Marc
- Fly, Vol. 4, Issue 4
Machine learning for neuroimaging with scikit-learn
journal, January 2014
- Abraham, Alexandre; Pedregosa, Fabian; Eickenberg, Michael
- Frontiers in Neuroinformatics, Vol. 8
HTSeq--a Python framework to work with high-throughput sequencing data
journal, September 2014
- Anders, S.; Pyl, P. T.; Huber, W.
- Bioinformatics, Vol. 31, Issue 2
The moulting hormone ecdysone is able to recognize target elements composed of direct repeats
journal, August 1995
- Paolo D'Avino, Pier; Crispi, Stefania; Cherbas, Lucy
- Molecular and Cellular Endocrinology, Vol. 113, Issue 1
Machine learning for neuroimaging with scikit-learn
journal, January 2014
- Abraham, Alexandre; Pedregosa, Fabian; Eickenberg, Michael
- Frontiers in Neuroinformatics, Vol. 8
FlyBase 102—advanced approaches to interrogating FlyBase
journal, November 2013
- St. Pierre, Susan E.; Ponting, Laura; Stefancsik, Raymund
- Nucleic Acids Research, Vol. 42, Issue D1
Quantifying similarity between motifs
journal, January 2007
- Gupta, Shobhit; Stamatoyannopoulos, John A.; Bailey, Timothy L.
- Genome Biology, Vol. 8, Issue 2
Multiple O -glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
journal, July 2011
- Leonardi, Jessica; Fernandez-Valdivia, Rodrigo; Li, Yi-Dong
- Development, Vol. 138, Issue 16
Hormone-Responsive Enhancer-Activity Maps Reveal Predictive Motifs, Indirect Repression, and Targeting of Closed Chromatin
journal, April 2014
- Shlyueva, Daria; Stelzer, Christoph; Gerlach, Daniel
- Molecular Cell, Vol. 54, Issue 1
The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis
journal, November 2005
- Badenhorst, P.
- Genes & Development, Vol. 19, Issue 21
Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization
journal, October 2015
- Dequéant, Mary-Lee; Fagegaltier, Delphine; Hu, Yanhui
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 42
Targeting bromodomains: epigenetic readers of lysine acetylation
journal, April 2014
- Filippakopoulos, Panagis; Knapp, Stefan
- Nature Reviews Drug Discovery, Vol. 13, Issue 5
Newly established cell lines fromDrosophila larval CNS express neural specific characteristics
journal, April 1994
- Ui, Kumiko; Nishihara, Shoko; Sakuma, M.
- In Vitro Cellular & Developmental Biology - Animal, Vol. 30, Issue 4
The Putzig-NURF Nucleosome Remodeling Complex Is Required for Ecdysone Receptor Signaling and Innate Immunity in Drosophila melanogaster
journal, March 2011
- Kugler, Sabrina J.; Gehring, Eva-Maria; Wallkamm, Veronika
- Genetics, Vol. 188, Issue 1
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
journal, December 1993
- Yao, Tso-Pang; Forman, Barry Marc; Jiang, Zeyu
- Nature, Vol. 366, Issue 6454
Establishment of stable cell lines of Drosophila germ-line stem cells
journal, October 2006
- Niki, Y.; Yamaguchi, T.; Mahowald, A. P.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 44
Tissue-specific ecdysone responses: regulation of the Drosophila genes Eip28/29 and Eip40 during larval development
journal, December 1992
- Andres, Andrew J.; Cherbas, Peter
- Development, Vol. 116, Issue 4
The growth and differentiation in vitro of leg and wing imaginal disc cells from Drosophila melanogaster
journal, April 1988
- Currie, D. A.; Milner, M. J.; Evans, C. W.
- Development, Vol. 102, Issue 4
Works referencing / citing this record:
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journal, August 2016
- Ables, Elizabeth T.; Hwang, Grace H.; Finger, Danielle S.
- G3 Genes|Genomes|Genetics, Vol. 6, Issue 8
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journal, April 2019
- Uyehara, Christopher M.; McKay, Daniel J.
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 20
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posted_content, April 2019
- Sahu, Ranjan Kumar; Mutt, Eshita; Lakhotia, Subhash Chandra
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journal, December 2018
- Ma, Yiqin; McKay, Daniel J.; Buttitta, Laura
- PLOS Biology
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journal, May 2017
- Uyehara, Christopher M.; Nystrom, Spencer L.; Niederhuber, Matthew J.
- Genes & Development, Vol. 31, Issue 9
Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells
journal, September 2019
- Ma, Yiqin; McKay, Daniel J.; Buttitta, Laura
- PLOS Biology, Vol. 17, Issue 9
Generating and working with Drosophila cell cultures: Current challenges and opportunities
journal, December 2018
- Luhur, Arthur; Klueg, Kristin M.; Zelhof, Andrew C.
- Wiley Interdisciplinary Reviews: Developmental Biology, Vol. 8, Issue 3
Hormone-dependent control of developmental timing through regulation of chromatin accessibility
journal, May 2017
- Uyehara, Christopher M.; Nystrom, Spencer L.; Niederhuber, Matthew J.
- Genes & Development, Vol. 31, Issue 9
Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila
journal, April 2019
- Uyehara, Christopher M.; McKay, Daniel J.
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 20
Ecdysone signaling promotes expression of multifunctional RNA binding proteins essential for ovarian germline stem cell self-renewal in Drosophila
posted_content, February 2019
- Finger, Danielle S.; Holt, Vivian V.; Ables, Elizabeth T.
- bioRxiv
Hormone-dependent control of developmental timing through regulation of chromatin accessibility
text, January 2017
- M., Uyehara, Christopher; A., Buttitta, Laura; Yiqin, Ma,
- The University of North Carolina at Chapel Hill University Libraries
Ecdysone signaling induces two phases of cell cycle exit inDrosophilacells
journal, November 2016
- Guo, Yongfeng; Flegel, Kerry; Kumar, Jayashree
- Biology Open, Vol. 5, Issue 11
Ecdysone signaling promotes expression of multifunctional RNA binding proteins essential for ovarian germline stem cell self-renewal in Drosophila
posted_content, February 2019
- Finger, Danielle S.; Holt, Vivian V.; Ables, Elizabeth T.
- bioRxiv
Early transcriptional response pathways in Daphnia magna are coordinated in networks of crustacean-specific genes
journal, August 2017
- Orsini, Luisa; Brown, James B.; Shams Solari, Omid
- Molecular Ecology, Vol. 27, Issue 4