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Title: Functionally conserved enhancers with divergent sequences in distant vertebrates

To examine the contributions of sequence and function conservation in the evolution of enhancers, we systematically identified enhancers whose sequences are not conserved among distant groups of vertebrate species, but have homologous function and are likely to be derived from a common ancestral sequence. In conclusion, our approach combined comparative genomics and epigenomics to identify potential enhancer sequences in the genomes of three groups of distantly related vertebrate species.
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [4] ;  [2] ;  [5] ;  [3]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  2. Univ. of California San Francisco, San Francisco, CA (United States)
  3. Children's Hospital Oakland Research Institute, Oakland, CA (United States)
  4. US Dept. of Energy Joint Genome Institute, Walnut Creek, CA (United States)
  5. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); US Dept. of Energy Joint Genome Institute, Walnut Creek, CA (United States)
Publication Date:
OSTI Identifier:
1256483
Grant/Contract Number:
HL091495; AC02-05CH11231; R01HG005058; 1R01HG006768; R01HD059862; GM61390; 1R01DK090382; 1R01NS079231
Type:
Accepted Manuscript
Journal Name:
BMC Genomics
Additional Journal Information:
Journal Volume: 16; Journal Issue: 1; Journal ID: ISSN 1471-2164
Publisher:
Springer
Research Org:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES